Toxicology of chemical mixtures: a challenging quest along empirical sciences

Autor: Victor J. Feron, John P. Groten, Andreas P. Freidig, Wilbert H.M. Heijne, Rob H. Stierum

Publikováno v: Environmental Toxicology and Pharmacology. 18:185-192

This paper describes the “quest” of our institute trying to assess the toxicology of chemical mixtures. In this overview, we will discuss some critical developments in hazard identification and risk assessment of chemical mixtures during these pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054d9045c41b85c4ea550efa67867771
https://doi.org/10.1016/j.etap.2004.07.005

Transcriptome analysis provides new insights into liver changes induced in the rat upon dietary administration of the food additives butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole

Autor: Brian G. Lake, Mary P. Scott, Clive Meredith, Rob H. Stierum, Karin Junker, Ana Conesa, Wilbert H.M. Heijne, Ben van Ommen, R.J. Price, John P. Groten

Publikováno v: Food and Chemical Toxicology, 8, 46, 2616-2628

Transcriptomics was performed to gain insight into mechanisms of food additives butylated hydroxytoluene (BHT), curcumin (CC), propyl gallate (PG), and thiabendazole (TB), additives for which interactions in the liver can not be excluded. Additives w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de060b3e94aef081b36784556ae042ce
http://resolver.tudelft.nl/uuid:1cbf0fae-5a4d-4a04-8e5b-b96c03f31228

Profiles of metabolites and gene expression in rats with chemically induced hepatic necrosis

Autor: Ben van Ommen, Joop H. J. van Nesselrooij, John P. Groten, Wilbert H.M. Heijne, Robert-Jan A. N. Lamers, Peter J. van Bladeren

Publikováno v: Toxicologic Pathology 33 (2005) 4
Toxicologic Pathology, 4, 33, 425-433
Toxicologic Pathology, 33(4), 425-433

This study investigated whether integrated analysis of transcriptomics and metabolomics data increased the sensitivity of detection and provided new insight in the mechanisms of hepatotoxicity. Metabolite levels in plasma or urine were analyzed in re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29879d52361077ee0467f05ad855b069
https://research.wur.nl/en/publications/profiles-of-metabolites-and-gene-expression-in-rats-with-chemical

Toxicogenomic analysis of gene expression changes in rat liver after a 28-day oral benzene exposure

Autor: Ben van Ommen, Diana Jonker, Rob H. Stierum, Wilbert H.M. Heijne, John P. Groten

Publikováno v: Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis, 575(1-2), 85-101
Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 1-2, 575, 85-101
Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis 575 (2005) 1-2

Benzene is an industrial chemical, component of automobile exhaust and cigarette smoke. After hepatic bioactivation benzene induces bone marrow, blood and hepatic toxicity. Using a toxicogenomics approach this study analysed the effects of benzene at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba5cdc5e1c77fda9e1cab28419d8a9da
https://research.wur.nl/en/publications/toxicogenomic-analysis-of-gene-expression-changes-in-rat-liver-af

Molecular modeling of the bacterial outer membrane receptor energizer, ExbBD/TonB, based on homology with the flagellar motor, MotAB

Autor: Milton H. Saier, Yufeng Zhai, Wilbert H.M Heijne

Publikováno v: Biochimica et biophysica acta. 1614(2)

The MotA/MotB proteins serve as the motor that drives bacterial flagellar rotation in response to the proton motive force (pmf). They have been shown to comprise a transmembrane proton pathway. The ExbB/ExbD/TonB protein complex serves to energize tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c01301d6e94c82cd490f37f3672fa3
https://pubmed.ncbi.nlm.nih.gov/12896813