Genome-wide gene expression changes in an industrial clavulanic acid overproduction strain ofStreptomyces clavuligerus

Autor: Marnix H. Medema, Mohammad Tauqeer Alam, Eriko Takano, Roel A. L. Bovenberg, Ulrike Müller, Wilbert H. M. Heijne, Marco A. van den Berg, Axel Christoph Trefzer, Rainer Breitling

Publikováno v: Microbial Biotechnology. 4:300-305

To increase production of the important pharmaceutical compound clavulanic acid, a β-lactamase inhibitor, both random mutagenesis approaches and rational engineering of Streptomyces clavuligerus strains have been extensively applied. Here, for the f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4dacd9e8e23491db880cb353ff3cce6c
https://doi.org/10.1111/j.1751-7915.2010.00226.x

Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology

Autor: Wilbert H. M. Heijne, John P. Groten, Rob H. Stierum, B. van Ommen, Anne S. Kienhuis

Publikováno v: Expert Review of Proteomics 2 (2005) 5
Expert Review of Proteomics, 2(5), 767-780
Expert Review of Proteomics, 2(5), 767-780. Expert Reviews Ltd.

Toxicogenomics can facilitate the identification and characterization of toxicity, as illustrated in this review. Toxicogenomics, the application of the functional genomics technologies (transcriptomics, proteomics and metabolomics) in toxicology ena

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526663888aa9900df5ff242bb88b6a05
https://doi.org/10.1586/14789450.2.5.767

Sample preparation and biostatistics for integrated genomics approaches

Autor: Hein, Stam, Michiel, Akeroyd, Hilly, Menke, Renger H, Jellema, Fredoen, Valianpour, Wilbert H M, Heijne, Maurien M A, Olsthoorn, Sabine, Metzelaar, Viktor M, Boer, Carlos M F M, Ribeiro, Philippe, Gaudin, Cees M J, Sagt

Publikováno v: Methods in molecular biology (Clifton, N.J.). 985

Genomics is based on the ability to determine the transcriptome, proteome, and metabolome of a cell. These technologies only have added value when they are integrated and based on robust and reproducible workflows. This chapter describes the experime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5293f3daf6653068f7fe996fe3d7e466
https://pubmed.ncbi.nlm.nih.gov/23417814

De novo sequencing, assembly and analysis of the genome of the laboratory strain Saccharomyces cerevisiae CEN.PK113-7D, a model for modern industrial biotechnology

Autor: Marcel J. T. Reinders, Paul Klaassen, Jurgen F. Nijkamp, Stefan de Kok, Marcel van den Broek, Marijke A. H. Luttik, Darren Platt, Wilbert H. M. Heijne, Lizanne Bosman, Chris J. Paddon, Jean-Marc Daran, Roeland C. H. J. van Ham, Peter Kötter, Jack T. Pronk, Jens Nielsen, Dick de Ridder, Pascale Daran-Lapujade, Wanwipa Vongsangnak, Erwin Datema

Publikováno v: Microbial Cell Factories, Vol 11, Iss 1, p 36 (2012)
Microbial Cell Factories 11 (2012)
Microbial Cell Factories
Microbial Cell Factories, 11, 2012
Microbial Cell Factories, 11

Saccharomyces cerevisiae CEN.PK 113-7D is widely used for metabolic engineering and systems biology research in industry and academia. We sequenced, assembled, annotated and analyzed its genome. Single-nucleotide variations (SNV), insertions/deletion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f65e9c648b30a3ef60b99425fdc7f7
https://doi.org/10.1186/1475-2859-11-36