Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Wilbert Bitter"'
Autor:
Beatriz Izquierdo Lafuente, Theo Verboom, Sita Coenraads, Roy Ummels, Wilbert Bitter, Alexander Speer
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 6 (2024)
ABSTRACT Vitamin B12 (B12) serves as a critical cofactor within mycobacterial metabolism. While some pathogenic strains can synthesize B12 de novo, others rely on host-acquired B12. In this investigation, we studied the transport of vitamin B12 in My
Externí odkaz:
https://doaj.org/article/81c6e0debf22470181d72ec94c5a4631
Autor:
Ilona van Alen, Mayra A. Aguirre García, Janneke J. Maaskant, Coenraad P. Kuijl, Wilbert Bitter, Annemarie H. Meijer, Marcellus Ubbink
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract The β-lactamase of Mycobacterium tuberculosis, BlaC, hydrolyzes β-lactam antibiotics, hindering the use of these antibiotics for the treatment of tuberculosis. Inhibitors, such as avibactam, can reversibly inhibit the enzyme, allowing for
Externí odkaz:
https://doaj.org/article/a12ee8f2c8fe4e89934290ceb65b2da1
Autor:
Joaquín R. Otero-Asman, Ana Sánchez-Jiménez, Karlijn C. Bastiaansen, Sarah Wettstadt, Cristina Civantos, Alicia García-Puente, Wilbert Bitter, María A. Llamas
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107216- (2023)
Summary: Cell-surface signaling (CSS) is a signal transfer system of Gram-negative bacteria that produces the activation of an extracytoplasmic function σ factor (σECF) in the cytosol in response to an extracellular signal. Activation requires the
Externí odkaz:
https://doaj.org/article/9bdae140669a4af9867ed03a82f13b0f
Autor:
Eric Eldering, Lisette Waanders, Lieve E H van der Donk, Louis S Ates, Janneke Maaskant, John L van Hamme, Jaco A C van Bruggen, Joanne M Rietveld, Wilbert Bitter, Teunis B H Geijtenbeek, Coenraad P Kuijl
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 4 (2023)
Background Interferon (IFN)-β induction via activation of the stimulator of interferon genes (STING) pathway has shown promising results in tumor models. STING is activated by cyclic dinucleotides such as cyclic GMP–AMP dinucleotides with phosphod
Externí odkaz:
https://doaj.org/article/31940c490bd64fc09c995d4d78516705
Autor:
Merel P. M. Damen, Aniek S. Meijers, Esther M. Keizer, Sander R. Piersma, Connie R. Jiménez, Coenraad P. Kuijl, Wilbert Bitter, Edith N. G. Houben
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Mycobacteria use specialized type VII secretion systems (T7SSs) to secrete proteins across their diderm cell envelope. One of the T7SS subtypes, named ESX-1, is a major virulence determinant in pathogenic species such as Mycobacterium tuberc
Externí odkaz:
https://doaj.org/article/6d89b33110a1441294f5c9186621cb08
Autor:
Michaela Wenzel, Marien P. Dekker, Biwen Wang, Maroeska J. Burggraaf, Wilbert Bitter, Jan R. T. van Weering, Leendert W. Hamoen
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Wenzel et al. developed a flat embedding method for TEM, which increases the fraction of appropriately orientated cells per image, making it easier to quantify cell morphology. They find that tetracycline-treated B. subtilis shows membrane lesions an
Externí odkaz:
https://doaj.org/article/6891a8b700bc4b0d86ca8c303d7203c1
Autor:
Vien Q. T. Ho, Mark K. Rong, Eva Habjan, Samantha D. Bommer, Thang V. Pham, Sander R. Piersma, Wilbert Bitter, Eelco Ruijter, Alexander Speer
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 211 (2023)
The ESX-5 secretion system is essential for the viability and virulence of slow-growing pathogenic mycobacterial species. In this study, we identified a 1,2,4-oxadiazole derivative as a putative effector of the ESX-5 secretion system. We confirmed th
Externí odkaz:
https://doaj.org/article/ba497c40122b4f66a0f66f5d3ffc5e2c
Autor:
Eva Habjan, Vien Q. T. Ho, James Gallant, Gunny van Stempvoort, Kin Ki Jim, Coen Kuijl, Daan P. Geerke, Wilbert Bitter, Alexander Speer
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 12 (2021)
Finding new anti-tuberculosis compounds with convincing in vivo activity is an ongoing global challenge to fight the emergence of multidrug-resistant Mycobacterium tuberculosis isolates. In this study, we exploited the medium-throughput capabilities
Externí odkaz:
https://doaj.org/article/39606835a70f4e1685863ba3b6a406f5
Autor:
James Gallant, Tiaan Heunis, Caroline Beltran, Karin Schildermans, Sven Bruijns, Inge Mertens, Wilbert Bitter, Samantha L. Sampson
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
It was previously shown that secretion of PE-PGRS and PPE-MPTR proteins is abolished in clinical M. tuberculosis isolates with a deletion in the ppe38-71 operon, which is associated with increased virulence. Here we investigate the proteins dependent
Externí odkaz:
https://doaj.org/article/42db7efd661d44a59eea153e178e7947
Autor:
Sanne van der Niet, Maaike van Zon, Karin de Punder, Anita Grootemaat, Sofie Rutten, Simone J. C. F. M. Moorlag, Diane Houben, Astrid M. van der Sar, Wilbert Bitter, Roland Brosch, Rogelio Hernandez Pando, Maria T. Pena, Peter J. Peters, Eric A. Reits, Katrin D. Mayer-Barber, Nicole N. van der Wel
Publikováno v:
mSphere, Vol 6, Iss 3 (2021)
For decades, Mycobacterium tuberculosis
Externí odkaz:
https://doaj.org/article/e730026f181142668249df16e8486b5a