Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Wilbee, D. Sasikala"'
Autor:
Sharanya, C. S.1 (AUTHOR), Wilbee, D. Sasikala1,2 (AUTHOR), Sathi, Shijulal Nelson3 (AUTHOR), Natarajan, Kathiresan1 (AUTHOR) kathiresan@rgcb.res.in
Publikováno v:
Scientific Reports. 7/13/2024, Vol. 14 Issue 1, p1-15. 15p.
Autor:
Wilbee D. Sasikala, Arnab Mukherjee
Publikováno v:
Physical Chemistry Chemical Physics. 18:10383-10391
Proflavine is a small molecule that intercalates into DNA and, thereby, acts as an anticancer agent. Intercalation of proflavine is shown to be a two-step process in which the first step is believed to be the formation of a pre-intercalative outside
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad700046a8640d1f5ed1a742161fdcd
https://doi.org/10.1039/c5cp07789c
https://doi.org/10.1039/c5cp07789c
Publikováno v:
The Journal of Physical Chemistry B. 119:11590-11596
Binding of transcription factor (TF) proteins with DNA may cause severe kinks in the latter. Here, we investigate the molecular origin of the DNA kinks observed in the TF-DNA complexes using small molecule intercalation pathway, crystallographic anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7331757de85bb574ed0e74a542b4e6f7
https://doi.org/10.1021/acs.jpcb.5b06229
https://doi.org/10.1021/acs.jpcb.5b06229
Autor:
Arnab Mukherjee, Wilbee D. Sasikala
Publikováno v:
The Journal of Physical Chemistry B. 116:12208-12212
DNA intercalation, a biophysical process of enormous clinical significance, has surprisingly eluded molecular understanding for several decades. With appropriate configurational restraint (to prevent dissociation) in all-atom metadynamics simulations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20c0d23405590d8f0eea87309aa777c
https://doi.org/10.1021/jp307911r
https://doi.org/10.1021/jp307911r
Autor:
Wilbee D. Sasikala, Arnab Mukherjee
Publikováno v:
The journal of physical chemistry. B. 118(36)
Entropy of water plays an important role in both chemical and biological processes e.g. hydrophobic effect, molecular recognition etc. Here we use a new approach to calculate translational and rotational entropy of the individual water molecules arou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9192875a7d98a6281621910af72305b6
https://pubmed.ncbi.nlm.nih.gov/25133988
https://pubmed.ncbi.nlm.nih.gov/25133988
Autor:
Arnab, Mukherjee, Wilbee D, Sasikala
Publikováno v:
Advances in protein chemistry and structural biology. 92
The ability of small molecules to perturb the natural structure and dynamics of nucleic acids is intriguing and has potential applications in cancer therapeutics. Intercalation is a special binding mode where the planar aromatic moiety of a small mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a1189edc64936a1197246b9e20e7ddcd
https://pubmed.ncbi.nlm.nih.gov/23954098
https://pubmed.ncbi.nlm.nih.gov/23954098
Autor:
Arnab Mukherjee, Wilbee D. Sasikala
Publikováno v:
Physical chemistry chemical physics : PCCP. 15(17)
DNA intercalation is a clinically relevant biophysical process due to its potential to inhibit the growth and survival of tumor cells and microbes through the arrest of the transcription and replication processes. Extensive kinetic and thermodynamic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45e4e62f7b0ffe2e7acb9662447e46b
https://pubmed.ncbi.nlm.nih.gov/23525232
https://pubmed.ncbi.nlm.nih.gov/23525232
Autor:
Arnab Mukherjee, Wilbee D. Sasikala
The ability of small molecules to perturb the natural structure and dynamics of nucleic acids is intriguing and has potential applications in cancer therapeutics. Intercalation is a special binding mode where the planar aromatic moiety of a small mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4e8c6d5a1ba11404fab9161a5e9f3fd
https://doi.org/10.1016/b978-0-12-411636-8.00001-8
https://doi.org/10.1016/b978-0-12-411636-8.00001-8
Publikováno v:
Chemphyschem : a European journal of chemical physics and physical chemistry. 13(8)
Flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) are derivatives of riboflavin (RF), a water-soluble vitamin, more commonly known as vitamin B(2). Flavins have attracted special attention in the last few years because of the recent d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7d0a33131b8223eeda46be742abf75
https://pubmed.ncbi.nlm.nih.gov/22532419
https://pubmed.ncbi.nlm.nih.gov/22532419
Publikováno v:
Journal of Physical Chemistry B; Sep2015, Vol. 119 Issue 35, p11590-11596, 7p