Výsledky vyhledávání - "Wil F. Kopatz"

Structure‐function of anticoagulant TIX‐5, the inhibitor of factor Xa‐mediated FV activation

Autor: Wil F. Kopatz, Cornelis van 't Veer, J. Arnoud Marquart, Joost C. M. Meijers, Tom van der Poll, Mettine H.A. Bos, Priyanka Sharma, Gerry A. F. Nicolaes, Tim J. Schuijt, Tilman M. Hackeng, Daniëlle Kruijswijk, Anja Maag

Publikováno v: Journal of Thrombosis and Haemostasis
Journal of thrombosis and haemostasis, 19(7), 1697-1708. Wiley-Blackwell
Journal of Thrombosis and Haemostasis, 19(7), 1697-1708. WILEY
Journal of Thrombosis and Haemostasis, 19(7), 1697-1708. Wiley

Background The prothrombinase complex consists of factors Xa (FXa) and Va (FVa) on an anionic phospholipid surface and converts prothrombin into thrombin. Both coagulation factors require activation before complex assembly. We recently identified TIX

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d21cd6d0ca3e9b905a305f90e04863
http://europepmc.org/articles/PMC8360041

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Major bleeding during oral anticoagulant therapy associated with factor V activation by factor Xa

Autor: Wil F. Kopatz, Tom van der Poll, Nienke van Rein, Stella Thomassen, Anja Maag, Rodney M. Camire, Mettine H.A. Bos, Tilman M. Hackeng, Tim J. Schuijt, Daniëlle Kruijswijk, Joost C. M. Meijers, Cornelis van 't Veer

Publikováno v: Journal of thrombosis and haemostasis. Wiley-Blackwell
Journal of Thrombosis and Haemostasis, 20(2), 328-338. Wiley
Journal of Thrombosis and Haemostasis, 20(2), 328-338. WILEY

Objective: Plasma thrombin generation (TG) provides important information on coagulation status; however, current TG output parameters do not predict major bleeding of patients on anticoagulants. We recently reported that factor V (FV) activation by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09aa79ddd5efbfe74687e858cf3df762
https://pure.amc.nl/en/publications/major-bleeding-during-oral-anticoagulant-therapy-associated-with-factor-v-activation-by-factor-xa(af4a4f98-184f-4181-9cd0-44c5218b3a60).html

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Use of DOAC Stop for elimination of anticoagulants in the thrombin generation assay

Autor: Joost C. M. Meijers, Wil F. Kopatz, Herm Jan M. Brinkman

Publikováno v: Thrombosis research, 170, 97-101. Elsevier Limited

Calibrated automated thrombography (CAT) is useful in monitoring the anticoagulant status of patients treated with direct oral anticoagulants (DOACs). This as well as other applications of the CAT are hampered by the wide inter-individual variation,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c8ecab29e7e9f991a64381208b74d9
https://doi.org/10.1016/j.thromres.2018.08.014

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The intestinal microbiome potentially affects thrombin generation in human subjects

Autor: Max Nieuwdorp, Ruud S. Kootte, Thijs E. van Mens, Wil F. Kopatz, Harry R. Büller, Henri H. Versteeg, Christoph H. Borchers, Yassene Mohammed

Publikováno v: Journal of thrombosis and haemostasis, 18(3), 642-650. Wiley-Blackwell
Journal of Thrombosis and Haemostasis

Background The intestinal microbiome plays a versatile role in the etiology of arterial thrombosis. In venous thrombosis, driven chiefly by plasma coagulation, no such role has yet been established. We hypothesized that the intestinal microbiome comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49792e636b254979a926f383a73e705
https://hdl.handle.net/1887/121374

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Abnormal coagulation and enhanced fibrinolysis due to lysinuric protein intolerance associates with bleeds and renal impairment

Autor: Hanna H. Pitkänen, Wil F. Kopatz, Joost C. M. Meijers, M. Pikta, Herm Jan M. Brinkman, Marleen Zuurveld, Laura Tanner, Harri Niinikoski, Riitta Lassila, Mari Kärki, Kirsti Näntö-Salonen

Publikováno v: Haemophilia, 24(5), e312-e321. Wiley-Blackwell

Introduction: Lysinuric protein intolerance (LPI), a rare autosomal recessive transport disorder of cationic amino acids lysine, arginine and ornithine, affects intestines, lungs, liver and kidneys. LPI patients may display potentially life-threateni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe5b6d6ce86ecb9171db859d12f1ff1
http://hdl.handle.net/10138/308858

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Dynamics of von Willebrand factor reactivity in sickle cell disease during vaso-occlusive crisis and steady state

Autor: Karin Fijnvandraat, Bart J. Biemond, Brenda M. Luken, Erfan Nur, Wil F. Kopatz, C. F. J. van Tuijn, Rolf T. Urbanus, Joep W. R. Sins, D. P. M. Brandjes, Joost C. M. Meijers, Sacha Zeerleder, Marein Schimmel

Publikováno v: Journal of thrombosis and haemostasis, 15(7), 1392-1402. Wiley-Blackwell
Journal of Thrombosis and Haemostasis, 15(7), 1392. Wiley-Blackwell

Essentials The role of von Willebrand Factor (VWF) in the pathophysiology of sickle cell disease is unclear. We assessed markers of VWF during admission for vaso-occlusive crisis (VOC) and steady state. VWF reactivity was higher during VOC and was as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152c9d54bf0b5b1c4779bc6e74566ae3
https://dspace.library.uu.nl/handle/1874/354755

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