Defining preBötzinger Complex Rhythm- and Pattern-Generating Neural Microcircuits In Vivo

Autor: Jack L. Feldman, Yan Cui, Yu Zheng, David H. Sherman, Kaiwen Kam, Wiktor A. Janczewski

Publikováno v: Neuron. 91:602-614

Normal breathing in rodents requires activity of glutamatergic Dbx1-derived (Dbx1(+)) preBötzinger Complex (preBötC) neurons expressing somatostatin (SST). We combined in vivo optogenetic and pharmacological perturbations to elucidate the functiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b878e19c95e4119084dc9b314d39cb
https://doi.org/10.1016/j.neuron.2016.07.003

The peptidergic control circuit for sighing

Autor: Silvia Pagliardini, Peng Li, Kaiwen Kam, Wiktor A. Janczewski, Kevin Yackle, Mark A. Krasnow, Jack L. Feldman

Publikováno v: Li, P; Janczewski, WA; Yackle, K; Kam, K; Pagliardini, S; Krasnow, MA; et al.(2016). The peptidergic control circuit for sighing. Nature, 530(7590), 293-297. doi: 10.1038/nature16964. UCLA: Retrieved from: http://www.escholarship.org/uc/item/7tr632h1
Nature, vol 530, iss 7590

© 2016 Macmillan Publishers Limited. Sighs are long, deep breaths expressing sadness, relief or exhaustion. Sighs also occur spontaneously every few minutes to reinflate alveoli, and sighing increases under hypoxia, stress, and certain psychiatric c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea61b30ede25e5fd4a092a223fd1e592
http://www.escholarship.org/uc/item/7tr632h1

Active Expiration Induced by Excitation of Ventral Medulla in Adult Anesthetized Rats

Autor: Karl Deisseroth, Clayton T. Dickson, Jack L. Feldman, Wenbin Tan, Silvia Pagliardini, Wiktor A. Janczewski

Publikováno v: The Journal of Neuroscience. 31:2895-2905

Data from perinatal and juvenile rodents support our hypothesis that the preBötzinger complex generates inspiratory rhythm and the retrotrapezoid nucleus–parafacial respiratory group (RTN/pFRG) generates active expiration (AE). Although the role o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b29b9fddaa18ac142f01e81ca9b833d
https://doi.org/10.1523/jneurosci.5338-10.2011

Opioid‐resistant respiratory pathway from the preinspiratory neurones to abdominal muscles: in vivo and in vitro study in the newborn rat

Autor: Ikuo Homma, Wiktor A. Janczewski, Jack L. Feldman, Hiroshi Onimaru

Publikováno v: The Journal of Physiology. 545:1017-1026

We report that after spontaneous breathing movements are stopped by administration of opioids (opioid-induced apnoea) in neonatal rats, abdominal muscles continue to contract at a rate similar to that observed during periods of ventilation. Correspon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eabf030a33348da104c32d5a161ad76
https://doi.org/10.1113/jphysiol.2002.023408

Silencing preBötzinger Complex somatostatin-expressing neurons induces persistent apnea in awake rat

Autor: Wenbin Tan, Edward M. Callaway, Jack L. Feldman, Wiktor A. Janczewski, Xuesi M. Shao, Paul Yang

Publikováno v: Nature Neuroscience. 11:538-540

Delineating neurons that underlie complex behaviors is of fundamental interest. Using adeno-associated virus 2, we expressed the Drosophila allatostatin receptor in somatostatin (Sst)-expressing neurons in the preBötzinger Complex (preBötC). Rapid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135a9335dcd9ec5940407f084e0f8f1a
https://doi.org/10.1038/nn.2104