Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Wijnand J. C. van der Velden"'
Autor:
Christian B. Billesbølle, Claire A. de March, Wijnand J. C. van der Velden, Ning Ma, Jeevan Tewari, Claudia Llinas del Torrent, Linus Li, Bryan Faust, Nagarajan Vaidehi, Hiroaki Matsunami, Aashish Manglik
Our sense of smell enables us to navigate a vast space of chemically diverse odor molecules. This task is accomplished by the combinatorial activation of approximately 400 olfactory G protein-coupled receptors (GPCRs) encoded in the human genome1–3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b631cd2538099921fc927df0be52bc6
https://doi.org/10.1101/2022.12.20.520951
https://doi.org/10.1101/2022.12.20.520951
Autor:
Olav Larsen, Wijnand J. C. van der Velden, Maša Mavri, Sara Schuermans, Pia C. Rummel, Stefanie Karlshøj, Martin Gustavsson, Paul Proost, Jon Våbenø, Mette M. Rosenkilde
Publikováno v:
Larsen, O, van der Velden, W J C, Mavri, M, Schuermans, S, Rummel, P C, Karlshøj, S, Gustavsson, M, Proost, P, Våbenø, J & Rosenkilde, M M 2022, ' Identification of a conserved chemokine receptor motif that enables ligand discrimination ', Science Signaling, vol. 15, no. 724, eabg7042 . https://doi.org/10.1126/scisignal.abg7042
Science signaling, vol. 15, no. 724, eabg7042, 2022.
Science signaling, vol. 15, no. 724, eabg7042, 2022.
Extensive ligand-receptor promiscuity in the chemokine signaling system balances beneficial redundancy and specificity. However, this feature poses a major challenge to selectively modulate the system pharmacologically. Here, we identified a conserve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14bcae7eb9f5ec49e63c896e32d00b6
https://curis.ku.dk/portal/da/publications/identification-of-a-conserved-chemokine-receptor-motif-that-enables-ligand-discrimination(29f6fc1f-9d65-409d-be3b-655cb9461521).html
https://curis.ku.dk/portal/da/publications/identification-of-a-conserved-chemokine-receptor-motif-that-enables-ligand-discrimination(29f6fc1f-9d65-409d-be3b-655cb9461521).html
Autor:
Annelien J.M. Zweemer, Adriaan P. IJzerman, Roy M. Kreekel, Eelke B. Lenselink, Jacobus P. D. van Veldhoven, Natalia V. Ortiz Zacarías, Wijnand J. C. van der Velden, Laura Portner, Laura H. Heitman, Salviana Ullo, Eric van Spronsen, Kenny Oenema, Margo Veenhuizen
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 61(20), 9146-9161. AMER CHEMICAL SOC
Journal of Medicinal Chemistry, 61(20), 9146-9161. AMER CHEMICAL SOC
The recent crystal structures of CC chemokine receptors 2 and 9 (CCR2 and CCR9) have provided structural evidence for an allosteric, intracellular binding site. The high conservation of residues involved in this site suggests its presence in most che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7bf8903cba6da4ac2be92e68df98b32
https://doi.org/10.1021/acs.jmedchem.8b00605
https://doi.org/10.1021/acs.jmedchem.8b00605
