Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Wijnand Helfrich"'
Autor:
Isabel Britsch, Anne P. van Wijngaarden, Xiurong Ke, Mark. A.J.M. Hendriks, Douwe F. Samplonius, Emily M. Ploeg, Wijnand Helfrich
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTTypically, anticancer CD8pos T cells occur at low frequencies and become increasingly impaired in the tumor micro environment. In contrast, antiviral CD8pos T cells display a much higher polyclonality, frequency, and functionality. In particu
Externí odkaz:
https://doaj.org/article/0d39d08c9dd24183a6b9857e3242983a
Autor:
Hao Zhang, Emily Maria Ploeg, Douwe Freerk Samplonius, Xiao Xiong, Xiurong Ke, Mark Alexander Johannes Martinus Hendriks, Isabel Britsch, Anne Paulien van Wijngaarden, Wijnand Helfrich
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 9 (2023)
Background CD73 is an ecto-enzyme that is involved in the conversion of pro-inflammatory extracellular ATP (eATP) excreted by cancer cells under stress to anti-inflammatory adenosine (ADO). A broad variety of solid cancer types was shown to exploit C
Externí odkaz:
https://doaj.org/article/6a3418819425477e9bac1effb2188d03
Autor:
Hugo Helbert, Emily M. Ploeg, Douwe F. Samplonius, Simon N. Blok, Ines F. Antunes, Verena I. Böhmer, Gert Luurtsema, Rudi A. J. O. Dierckx, Ben L. Feringa, Philip H. Elsinga, Wiktor Szymanski, Wijnand Helfrich
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 7, Iss 1, Pp 1-11 (2022)
Abstract Background Pretargeted immuno-PET tumor imaging has emerged as a valuable diagnostic strategy that combines the high specificity of antibody-antigen interaction with the high signal and image resolution offered by short-lived PET isotopes, w
Externí odkaz:
https://doaj.org/article/9b6014dad4f74837bdc42ac447f94401
Autor:
Xiao Xiong, Xiurong Ke, Lu Wang, Yusheng Lin, Shuhong Wang, Zhimeng Yao, Kai Li, Yichen Luo, Fan Liu, Yunlong Pan, Sai‐Ching J. Yeung, Wijnand Helfrich, Hao Zhang
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 8, Pp n/a-n/a (2022)
Abstract Cancer vaccines critically rely on the availability of targetable immunogenic cancer‐specific neoepitopes. However, mutation‐based immunogenic neoantigens are rare or even non‐existent in subgroups of cancer types. To address this issu
Externí odkaz:
https://doaj.org/article/243a65420eaa4f3a8de40b1aa3f2e802
Publikováno v:
Cancers, Vol 15, Iss 15, p 3767 (2023)
Infection with cytomegalovirus (CMV) is highly prevalent in the general population and largely controlled by CD8pos T cells. Intriguingly, anti-CMV T cells accumulate over time to extraordinarily high numbers, are frequently present as tumor-resident
Externí odkaz:
https://doaj.org/article/edecda3b560a45199f02f9828e5cd259
Autor:
Emily Maria Ploeg, Isabel Britsch, Anne Paulien van Wijngaarden, Xiurong Ke, Mark Alexander Johannes Martinus Hendriks, Douwe Freerk Samplonius, Wijnand Helfrich
Publikováno v:
Cancers, Vol 15, Iss 14, p 3651 (2023)
PD-1/PD-L1-inhibiting antibodies have shown disappointing efficacy in patients with refractory ovarian cancer (OC). Apparently, OC cells exploit nonoverlapping immunosuppressive mechanisms to evade the immune system. In this respect, the CD73-adenosi
Externí odkaz:
https://doaj.org/article/b8c8cac7cdf848c782022612e6e8b17c
Autor:
Mark A.J.M. Hendriks, Isabel Britsch, Xiurong Ke, Anne P. van Wijngarden, Douwe F. Samplonius, Emily M. Ploeg, Wijnand Helfrich
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Cancer cells exploit CD47 overexpression to inhibit phagocytic elimination and neoantigen processing via the myeloid CD47-SIRPα axis and thereby indirectly evade adaptive T cell immunity. Here, we report on a hitherto unrecognized direct immunoinhib
Externí odkaz:
https://doaj.org/article/98669fa6874142af8bbb8031277bb690
Autor:
Iris Koopmans, Djoke Hendriks, Douwe F. Samplonius, Robert J. van Ginkel, Sandra Heskamp, Peter J. Wierstra, Edwin Bremer, Wijnand Helfrich
Publikováno v:
OncoImmunology, Vol 7, Iss 8 (2018)
PD-L1-blocking antibodies produce significant clinical benefit in selected cancer patients by reactivating functionally-impaired antigen-experienced anticancer T cells. However, the efficacy of current PD-L1-blocking antibodies is potentially reduced
Externí odkaz:
https://doaj.org/article/e22cb3f785134639905fdb9be9107749
Autor:
Peter E. van Bommel, Yuan He, Ilona Schepel, Mark A. J. M. Hendriks, Valerie R. Wiersma, Robert J. van Ginkel, Tom van Meerten, Emanuele Ammatuna, Gerwin Huls, Douwe F. Samplonius, Wijnand Helfrich, Edwin Bremer
Publikováno v:
OncoImmunology, Vol 7, Iss 2 (2018)
Here, we report on a novel bispecific antibody-derivative, designated RTX-CD47, with unique capacity for CD20-directed inhibition of CD47-SIRPα “don't eat me” signaling. RTX-CD47 comprises a CD20-targeting scFv antibody fragment derived from rit
Externí odkaz:
https://doaj.org/article/28534e798d5449938af49fe87651c684
Autor:
Edwin Bremer, Douwe Samplonius, Bart-Jan Kroesen, Linda van Genne, Lou de Leij, Wijnand Helfrich
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 6, Iss 5, Pp 636-645 (2004)
Previously, we reported on the target cell-restricted fratricide apoptotic activity of scFvC54:sTRAIL, a fusion protein comprising human-soluble tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) genetically linked to the antibody fragme
Externí odkaz:
https://doaj.org/article/897acc757819435cab8a98826eacccd6