Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Wijnand, Helfrich"'
Autor:
Isabel Britsch, Anne P. van Wijngaarden, Xiurong Ke, Mark. A.J.M. Hendriks, Douwe F. Samplonius, Emily M. Ploeg, Wijnand Helfrich
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTTypically, anticancer CD8pos T cells occur at low frequencies and become increasingly impaired in the tumor micro environment. In contrast, antiviral CD8pos T cells display a much higher polyclonality, frequency, and functionality. In particu
Externí odkaz:
https://doaj.org/article/0d39d08c9dd24183a6b9857e3242983a
Autor:
Hao Zhang, Emily Maria Ploeg, Douwe Freerk Samplonius, Xiao Xiong, Xiurong Ke, Mark Alexander Johannes Martinus Hendriks, Isabel Britsch, Anne Paulien van Wijngaarden, Wijnand Helfrich
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 9 (2023)
Background CD73 is an ecto-enzyme that is involved in the conversion of pro-inflammatory extracellular ATP (eATP) excreted by cancer cells under stress to anti-inflammatory adenosine (ADO). A broad variety of solid cancer types was shown to exploit C
Externí odkaz:
https://doaj.org/article/6a3418819425477e9bac1effb2188d03
Autor:
Hugo Helbert, Emily M. Ploeg, Douwe F. Samplonius, Simon N. Blok, Ines F. Antunes, Verena I. Böhmer, Gert Luurtsema, Rudi A. J. O. Dierckx, Ben L. Feringa, Philip H. Elsinga, Wiktor Szymanski, Wijnand Helfrich
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 7, Iss 1, Pp 1-11 (2022)
Abstract Background Pretargeted immuno-PET tumor imaging has emerged as a valuable diagnostic strategy that combines the high specificity of antibody-antigen interaction with the high signal and image resolution offered by short-lived PET isotopes, w
Externí odkaz:
https://doaj.org/article/9b6014dad4f74837bdc42ac447f94401
Autor:
Xiao Xiong, Xiurong Ke, Lu Wang, Yusheng Lin, Shuhong Wang, Zhimeng Yao, Kai Li, Yichen Luo, Fan Liu, Yunlong Pan, Sai‐Ching J. Yeung, Wijnand Helfrich, Hao Zhang
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 8, Pp n/a-n/a (2022)
Abstract Cancer vaccines critically rely on the availability of targetable immunogenic cancer‐specific neoepitopes. However, mutation‐based immunogenic neoantigens are rare or even non‐existent in subgroups of cancer types. To address this issu
Externí odkaz:
https://doaj.org/article/243a65420eaa4f3a8de40b1aa3f2e802
Autor:
Mark A.J.M. Hendriks, Isabel Britsch, Xiurong Ke, Anne P. van Wijngarden, Douwe F. Samplonius, Emily M. Ploeg, Wijnand Helfrich
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Cancer cells exploit CD47 overexpression to inhibit phagocytic elimination and neoantigen processing via the myeloid CD47-SIRPα axis and thereby indirectly evade adaptive T cell immunity. Here, we report on a hitherto unrecognized direct immunoinhib
Externí odkaz:
https://doaj.org/article/98669fa6874142af8bbb8031277bb690
Autor:
Mark A. J. M. Hendriks, Emily M. Ploeg, Iris Koopmans, Isabel Britsch, Xiurong Ke, Douwe F. Samplonius, Wijnand Helfrich
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Cancer cells overexpress CD47 to subvert phagocytic elimination and evade immunogenic processing of cancer antigens. Moreover, CD47 overexpression inhibits the antibody-dependent cellular phagocytosis (ADCP) and cytotoxicity (ADCC) activities of ther
Externí odkaz:
https://doaj.org/article/6ce893e0214243c392519ead7428b580
Autor:
Stefan Barth, Theo Thepen, Rainer Fischer, Wijnand Helfrich, Michael Huhn, Anh-Tuan Pham, Stefano Di Fiore, Lea Hein, Nina Berges, Katharina Arens, Judith Niesen, Radoslav Mladenov, Manal Amoury, Dmitrij Hristodorov
In normal epithelia, the epithelial cell adhesion molecule (EpCAM) expression is relatively low and only present at the basolateral cell surface. In contrast, EpCAM is aberrantly overexpressed in various human carcinomas. Therefore, EpCAM is consider
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea71e0953fc9d55f5c4cbe58b11d9e2b
https://doi.org/10.1158/1535-7163.c.6536832.v1
https://doi.org/10.1158/1535-7163.c.6536832.v1
Autor:
Stefan Barth, Theo Thepen, Rainer Fischer, Wijnand Helfrich, Michael Huhn, Anh-Tuan Pham, Stefano Di Fiore, Lea Hein, Nina Berges, Katharina Arens, Judith Niesen, Radoslav Mladenov, Manal Amoury, Dmitrij Hristodorov
Supplementary Figure 1. Cell-binding activity of anti-EpCAM(scFv)-MAP to further target cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce37cdf8635b8b1ddc6d600c2efea6d
https://doi.org/10.1158/1535-7163.22501572.v1
https://doi.org/10.1158/1535-7163.22501572.v1
Autor:
Edwin Bremer, Wijnand Helfrich, Baofeng Yang, Ate G.J. van der Zee, Harry G. Klip, Douwe F. Samplonius, Valerie R. Wiersma, Yunwei Wei, Marco de Bruyn
AVI file - 9112KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a15c3dbdd5c68bb4bea31093d615f0
https://doi.org/10.1158/1078-0432.22442565.v1
https://doi.org/10.1158/1078-0432.22442565.v1
Autor:
Edwin Bremer, Wijnand Helfrich, Baofeng Yang, Ate G.J. van der Zee, Harry G. Klip, Douwe F. Samplonius, Valerie R. Wiersma, Yunwei Wei, Marco de Bruyn
AVI file - 1941K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ff5187468e33b724e4c9e1e4692f1d
https://doi.org/10.1158/1078-0432.22442559
https://doi.org/10.1158/1078-0432.22442559