NS1 DNA vaccination protects against Zika infection through T cell–mediated immunity in immunocompetent mice

Autor: Rebecca Peterson, Zelalem A Mekonnen, Sarah A. Robertson, Jason Gummow, Jillian M. Carr, Natalie A. Prow, Dan H. Barouch, Michael R. Beard, Eric J. Gowans, Danushka K. Wijesundara, Peter Abbink, Branka Grubor-Bauk, John D. Hayball, Ashish C. Shrestha, Makutiro Ghislain Masavuli, Nicholas S. Eyre, Rafael A. Larocca

Publikováno v: Science Advances
Science advances, vol 5, iss 12

A novel T cell–based ZIKV vaccine, encoding NS1 protein, confers protection against systemic infection.
The causal association of Zika virus (ZIKV) with microcephaly, congenital malformations in infants, and Guillain-Barré syndrome in adults

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43aea95a84c5cf3f2f7790b9c4245bf3
http://europepmc.org/articles/PMC6905874

Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18-55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial.

Autor: Chappell KJ; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD, Australia; Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, QLD, Australia. Electronic address: k.chappell@uq.edu.au., Mordant FL; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, Australia., Amarilla AA; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia., Modhiran N; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia., Liang B; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia., Li Z; Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Wijesundara DK; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD, Australia., Lackenby JA; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD, Australia., Griffin P; Nucleus Network Brisbane Clinic, Herston, QLD, Australia; Department of Infectious Diseases, Mater Health, QLD, Australia; School of Medicine, The University of Queensland, St Lucia, QLD, Australia., Bennet JK; Tanawell Consulting, Melbourne, VIC, Australia., Hensen L; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, Australia., Zhang W; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, Australia., Nguyen THO; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, Australia., Tran MH; Agilex Biolabs, Thebarton, SA, Australia., Tapley P; Agilex Biolabs, Thebarton, SA, Australia., Barnes J; WHO Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Reading PC; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, Australia; WHO Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Kedzierska K; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, Australia., Ranasinghe C; Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Subbarao K; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, Australia; WHO Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Watterson D; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD, Australia; Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, QLD, Australia., Young PR; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD, Australia; Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, QLD, Australia., Munro TP; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD, Australia.

Publikováno v: EBioMedicine [EBioMedicine] 2023 Nov; Vol. 97, pp. 104842. Date of Electronic Publication: 2023 Oct 20.

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein.

Autor: Albornoz EA; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, St Lucia, QLD, 4072, Australia., Amarilla AA; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD, 4072, Australia., Modhiran N; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD, 4072, Australia.; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD, 4072, Australia., Parker S; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, St Lucia, QLD, 4072, Australia., Li XX; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, St Lucia, QLD, 4072, Australia., Wijesundara DK; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD, 4072, Australia.; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD, 4072, Australia.; Vaxxas Pty. Ltd., Woolloongabba, QLD, 4102, Australia., Aguado J; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD, 4072, Australia., Zamora AP; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD, 4072, Australia., McMillan CLD; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD, 4072, Australia., Liang B; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD, 4072, Australia., Peng NYG; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD, 4072, Australia., Sng JDJ; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD, 4072, Australia., Saima FT; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, St Lucia, QLD, 4072, Australia., Fung JN; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, St Lucia, QLD, 4072, Australia., Lee JD; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, St Lucia, QLD, 4072, Australia., Paramitha D; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD, 4072, Australia., Parry R; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD, 4072, Australia., Avumegah MS; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD, 4072, Australia.; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD, 4072, Australia., Isaacs A; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD, 4072, Australia., Lo MW; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, St Lucia, QLD, 4072, Australia., Miranda-Chacon Z; Institute of Medicine, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile.; Molecular Medicine Laboratory, Medical School, Universidad de Costa Rica, San Pedro, Costa Rica., Bradshaw D; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, St Lucia, QLD, 4072, Australia., Salinas-Rebolledo C; Institute of Medicine, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile., Rajapakse NW; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, St Lucia, QLD, 4072, Australia., Wolvetang EJ; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD, 4072, Australia., Munro TP; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD, 4072, Australia.; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD, 4072, Australia., Rojas-Fernandez A; Institute of Medicine, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile., Young PR; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD, 4072, Australia.; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD, 4072, Australia.; Australian Infectious Disease Research Centre, Global Virus Network Centre of Excellence Brisbane, Brisbane, QLD, 4072 and 4029, Australia., Stacey KJ; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD, 4072, Australia., Khromykh AA; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD, 4072, Australia.; Australian Infectious Disease Research Centre, Global Virus Network Centre of Excellence Brisbane, Brisbane, QLD, 4072 and 4029, Australia., Chappell KJ; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD, 4072, Australia.; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD, 4072, Australia.; Australian Infectious Disease Research Centre, Global Virus Network Centre of Excellence Brisbane, Brisbane, QLD, 4072 and 4029, Australia., Watterson D; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD, 4072, Australia. d.watterson@uq.edu.au., Woodruff TM; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, St Lucia, QLD, 4072, Australia. t.woodruff@uq.edu.au.; Queensland Brain Institute, University of Queensland, St Lucia, QLD, 4072, Australia. t.woodruff@uq.edu.au.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2023 Jul; Vol. 28 (7), pp. 2878-2893. Date of Electronic Publication: 2022 Nov 01.

Fear of Influenza Resurgence amid COVID-19 Pandemic: Need for Effective Flu Vaccine Still Exists.

Autor: Wijesundara DK; The School of Chemistry and Molecular Biosciences, The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia., Williams C; Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA., Sun W; Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA., Furuya AM; Pictor Limited, 40 Kenwyn Street, Parnell, Auckland 1052, New Zealand., Furuya Y; Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA.

Publikováno v: Vaccines [Vaccines (Basel)] 2021 Oct 18; Vol. 9 (10). Date of Electronic Publication: 2021 Oct 18.

Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2.

Autor: Watterson D; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia.; The Australian Institute for Bioengineering and Nanotechnology The University of Queensland St Lucia QLD Australia.; Australian Infectious Disease Research Centre, Global Virus Network Centre of Excellence The University of Queensland Brisbane QLD Australia., Wijesundara DK; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia.; The Australian Institute for Bioengineering and Nanotechnology The University of Queensland St Lucia QLD Australia., Modhiran N; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia.; The Australian Institute for Bioengineering and Nanotechnology The University of Queensland St Lucia QLD Australia., Mordant FL; Department of Microbiology and Immunology The University of Melbourne Peter Doherty Institute for Infection and Immunity Melbourne VIC Australia., Li Z; Department of Immunology and Infectious Disease The John Curtin School of Medical Research, The Australian National University Canberra ACT Australia., Avumegah MS; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia.; The Australian Institute for Bioengineering and Nanotechnology The University of Queensland St Lucia QLD Australia., McMillan CL; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia.; The Australian Institute for Bioengineering and Nanotechnology The University of Queensland St Lucia QLD Australia., Lackenby J; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia.; The Australian Institute for Bioengineering and Nanotechnology The University of Queensland St Lucia QLD Australia., Guilfoyle K; Viroclinics Xplore Schaijk The Netherlands., van Amerongen G; Viroclinics Xplore Schaijk The Netherlands., Stittelaar K; Viroclinics Xplore Schaijk The Netherlands., Cheung ST; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia., Bibby S; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia., Daleris M; The Australian Institute for Bioengineering and Nanotechnology The University of Queensland St Lucia QLD Australia., Hoger K; The Australian Institute for Bioengineering and Nanotechnology The University of Queensland St Lucia QLD Australia., Gillard M; The Australian Institute for Bioengineering and Nanotechnology The University of Queensland St Lucia QLD Australia., Radunz E; The Australian Institute for Bioengineering and Nanotechnology The University of Queensland St Lucia QLD Australia., Jones ML; The Australian Institute for Bioengineering and Nanotechnology The University of Queensland St Lucia QLD Australia., Hughes K; The Australian Institute for Bioengineering and Nanotechnology The University of Queensland St Lucia QLD Australia., Hughes B; The Australian Institute for Bioengineering and Nanotechnology The University of Queensland St Lucia QLD Australia., Goh J; The Australian Institute for Bioengineering and Nanotechnology The University of Queensland St Lucia QLD Australia., Edwards D; The Australian Institute for Bioengineering and Nanotechnology The University of Queensland St Lucia QLD Australia., Scoble J; CSIRO Manufacturing Parkville VIC Australia., Pearce L; CSIRO Manufacturing Parkville VIC Australia., Kowalczyk L; CSIRO Manufacturing Parkville VIC Australia., Phan T; CSIRO Manufacturing Parkville VIC Australia., La M; CSIRO Manufacturing Parkville VIC Australia., Lu L; CSIRO Manufacturing Parkville VIC Australia., Pham T; CSIRO Manufacturing Parkville VIC Australia., Zhou Q; CSIRO Manufacturing Parkville VIC Australia., Brockman DA; TetraQ The University of Queensland St Lucia QLD Australia., Morgan SJ; StageBio Mason OH USA., Lau C; University of Queensland Biological Resources The University of Queensland St Lucia QLD Australia., Tran MH; TetraQ The University of Queensland St Lucia QLD Australia., Tapley P; TetraQ The University of Queensland St Lucia QLD Australia., Villalón-Letelier F; Department of Microbiology and Immunology The University of Melbourne Peter Doherty Institute for Infection and Immunity Melbourne VIC Australia., Barnes J; WHO Collaborating Centre for Reference and Research on Influenza Peter Doherty Institute for Infection and Immunity Melbourne VIC Australia., Young A; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia.; The Australian Institute for Bioengineering and Nanotechnology The University of Queensland St Lucia QLD Australia., Jaberolansar N; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia.; The Australian Institute for Bioengineering and Nanotechnology The University of Queensland St Lucia QLD Australia., Scott CA; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia., Isaacs A; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia., Amarilla AA; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia., Khromykh AA; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia.; Australian Infectious Disease Research Centre, Global Virus Network Centre of Excellence The University of Queensland Brisbane QLD Australia., van den Brand JM; Division of Pathology Faculty of Veterinary Medicine Utrecht University Utrecht The Netherlands., Reading PC; Department of Microbiology and Immunology The University of Melbourne Peter Doherty Institute for Infection and Immunity Melbourne VIC Australia.; WHO Collaborating Centre for Reference and Research on Influenza Peter Doherty Institute for Infection and Immunity Melbourne VIC Australia., Ranasinghe C; Department of Immunology and Infectious Disease The John Curtin School of Medical Research, The Australian National University Canberra ACT Australia., Subbarao K; Department of Microbiology and Immunology The University of Melbourne Peter Doherty Institute for Infection and Immunity Melbourne VIC Australia.; WHO Collaborating Centre for Reference and Research on Influenza Peter Doherty Institute for Infection and Immunity Melbourne VIC Australia., Munro TP; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia.; The Australian Institute for Bioengineering and Nanotechnology The University of Queensland St Lucia QLD Australia., Young PR; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia.; The Australian Institute for Bioengineering and Nanotechnology The University of Queensland St Lucia QLD Australia.; Australian Infectious Disease Research Centre, Global Virus Network Centre of Excellence The University of Queensland Brisbane QLD Australia., Chappell KJ; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia.; The Australian Institute for Bioengineering and Nanotechnology The University of Queensland St Lucia QLD Australia.; Australian Infectious Disease Research Centre, Global Virus Network Centre of Excellence The University of Queensland Brisbane QLD Australia.

Publikováno v: Clinical & translational immunology [Clin Transl Immunology] 2021 Apr 05; Vol. 10 (4), pp. e1269. Date of Electronic Publication: 2021 Apr 05 (Print Publication: 2021).