Landau Damping of Spin Waves in Trapped Boltzmann Gases

Autor: Ragan, R. J., Mullin, W. J., Wiita, E. B.

A semiclassical method is used to study Landau damping of transverse pseudo-spin waves in harmonically trapped ultracold gases in the collisionless Boltzmann limit. In this approach, the time evolution of a spin is calculated numerically as it travel

Externí odkaz: http://arxiv.org/abs/cond-mat/0502189

MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia

Autor: Sanjiv, K., Calderón-Montaño, J.M., Pham, T.M., Erkers, T., Tsuber, V., Almlöf, I., Höglund, A., Heshmati, Y., Seashore-Ludlow, B., Nagesh Danda, A., Gad, H., Wiita, E., Göktürk, C., Rasti, A., Friedrich, S., Centio, A., Estruch, M., Våtsveen, T.K., Struyf, N., Visnes, T., Scobie, M., Koolmeister, T., Henriksson, M., Wallner, O., Sandvall, T., Lehmann, S., Theilgaard-Mönch, K., Garnett, M.J., Östling, P., Walfridsson, J., Helleday, T., Warpman Berglund, U.

Publikováno v: Sanjiv, K, Calderón-Montaño, J M, Pham, T M, Erkers, T, Tsuber, V, Almlöf, I, Höglund, A, Heshmati, Y, Seashore-Ludlow, B, Nagesh Danda, A, Gad, H, Wiita, E, Göktürk, C, Rasti, A, Friedrich, S, Centio, A, Estruch, M, Våtsveen, T K, Struyf, N, Visnes, T, Scobie, M, Koolmeister, T, Henriksson, M, Wallner, O, Sandvall, T, Lehmann, S, Theilgaard-Mönch, K, Garnett, M J, Östling, P, Walfridsson, J, Helleday, T & Warpman Berglund, U 2021, ' MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia ', Cancer Research, vol. 81, no. 22, pp. 5733-5744 . https://doi.org/10.1158/0008-5472.CAN-21-0061

Acute myeloid leukemia (AML) is an aggressive hematologic malignancy, exhibiting high levels of reactive oxygen species (ROS). ROS levels have been suggested to drive leukemogenesis and is thus a potential novel target for treating AML. MTH1 prevents

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fe8f359e7bf60879a83a3f3b3317ec5c
https://pubmed.ncbi.nlm.nih.gov/34593524

Targeting OGG1 arrests cancer cell proliferation by inducing replication stress

Autor: Visnes, T., Benítez-Buelga, C., Cázares-Körner, A., Sanjiv, K., Hanna, B.M.F., Mortusewicz, O., Rajagopal, V., Albers, J.J., Hagey, D.W., Bekkhus, T., Eshtad, S., Baquero, J.M., Masuyer, G., Wallner, O., Müller, S., Pham, T., Göktürk, C., Rasti, A., Suman, S., Torres-Ruiz, R., Sarno, A., Wiita, E., Homan, E.J., Karsten, S., Marimuthu, K., Michel, M., Koolmeister, T., Scobie, M., Loseva, O., Almlöf, I., Unterlass, J.E., Pettke, A., Boström, J., Pandey, M., Gad, H., Herr, P., Jemth, A.-S., El Andaloussi, S., Kalderén, C., Rodriguez-Perales, S., Benítez, J., Krokan, H.E., Altun, M., Stenmark, P., Berglund, U.W., Helleday, T.

Publikováno v: 12234-12251
Nucleic Acids Research

Altered oncogene expression in cancer cells causes loss of redox homeostasis resulting in oxidative DNA damage, e.g. 8-oxoguanine (8-oxoG), repaired by base excision repair (BER). PARP1 coordinates BER and relies on the upstream 8-oxoguanine-DNA glyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7fd8ce19837332df7926ecb7122c0d29
https://hdl.handle.net/11250/2788132

In Silico Druggability Assessment of the NUDIX Hydrolase Protein Family as a Workflow for Target Prioritization

Autor: Michel, M., Homan, E.J., Wiita, E., Pedersen, K., Almlöf, I., Gustavsson, A-L., Lundbäck, T., Helleday, T., Warpman Berglund, U.

Publikováno v: Frontiers in Chemistry

Computational chemistry has now been widely accepted as a useful tool for shortening lead times in early drug discovery. When selecting new potential drug targets, it is important to assess the likelihood of finding suitable starting points for lead

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e73e87bbf1102db700548f22755607ce
https://doi.org/10.26434/chemrxiv.10026929

Small-molecule inhibitor of OGG1 suppresses pro-inflammatory gene expression and inflammation

Autor: Visnes, T., Cázares-Körner, A., Hao, W., Wallner, O., Masuyer, G., Loseva, O., Mortusewicz, O., Wiita, E., Sarno, A., Manoilov, A., Astorga-Wells, J., Jemth, A., Pan, L., Sanjiv, K., Karsten, S., Gokturk, C., Grube, M., Homan, E., Hanna, B., Paulin, C., Pham, T., Rasti, A., Berglund, U., von Nicolai, C., Benitez-Buelga, C., Koolmeister, T., Ivanic, D., Iliev, P., Scobie, M., Krokan, H., Baranczewski, P., Artursson, P., Altun, M., Jensen, A., Kalderén, C., Ba, X., Zubarev, R., Stenmark, P., Boldogh, I., Helleday, T.

The onset of inflammation is associated with reactive oxygen species and oxidative damage to macromolecules like 7,8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine DNA glycosylase 1 (OGG1) binds 8-oxoG and because Ogg1-deficient mice are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::55622f15dd5d6dcb902ed2f0ac4c6a33