Zobrazeno 1 - 10
of 1 522
pro vyhledávání: '"Wigmore P"'
Deep Reinforcement Learning (DRL) offers a powerful approach to training neural network control policies for stochastic queuing networks (SQN). However, traditional DRL methods rely on offline simulations or static datasets, limiting their real-world
Externí odkaz:
http://arxiv.org/abs/2404.04106
Autor:
Soraya Kaewngam, Ram Prajit, Tanaporn Anosri, Kornrawee Suwannakot, Rasa Saenno, Nataya Sritawan, Anusara Aranarochana, Apiwat Sirichoat, Wanassanun Pannangrong, Peter Wigmore, Jariya Umka Welbat
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Treatment with valproic acid (VPA) can induce oxidative stress, leading to neuronal degeneration. Hesperidin (HSD) has an antioxidant function that can mitigate oxidative stress, thereby promoting hippocampal neurogenesis. Because brain func
Externí odkaz:
https://doaj.org/article/9339f79a48c6417caaf12fa40bd37cd6
Publikováno v:
BMJ Open, Vol 14, Iss 8 (2024)
Introduction The efficiency of multidisciplinary teams (MDTs) in cancer care hinges on facilitating clinicians’ cognitive processes as they navigate complex and uncertain judgements during treatment planning. When systems and workflows are not desi
Externí odkaz:
https://doaj.org/article/ceadb0684bf94574a10e2b255203bcc1
Autor:
Nguyen T. Van, Karen Zhang, Rachel M. Wigmore, Anne I. Kennedy, Carolina R. DaSilva, Jialing Huang, Manju Ambelil, Jose H. Villagomez, Gerald J. O’Connor, Randy S. Longman, Miao Cao, Adam E. Snook, Michael Platten, Gerard Kasenty, Luis J. Sigal, George C. Prendergast, Sangwon V. Kim
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Environmental factors are the major contributor to the onset of immunological disorders such as ulcerative colitis. However, their identities remain unclear. Here, we discover that the amount of consumed L-Tryptophan (L-Trp), a ubiquitous di
Externí odkaz:
https://doaj.org/article/ec2a535921bc46a180d596010b048d5b
Autor:
Ruridh Allen, MRCP, Chris J.C. Johnston, PhD, FRCS, Sarah Thomasset, PhD, FRCS, Rajan Ravindran, MS, FRCS, Stephen J. Wigmore, MD, FRCS, Nick I. Church, MD, FRCP
Publikováno v:
VideoGIE, Vol 8, Iss 11, Pp 464-468 (2023)
Externí odkaz:
https://doaj.org/article/e2540d50ab25439295e2604acc1bb975
Skeletal muscle analysis of cancer patients reveals a potential role for carnosine in muscle wasting
Autor:
Dheeraj Kumar Posa, Janice Miller, David Hoetker, Michael I. Ramage, Hong Gao, Jingjing Zhao, Benjamin Doelling, Aruni Bhatnagar, Stephen J. Wigmore, Richard J.E. Skipworth, Shahid P. Baba
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 4, Pp 1802-1814 (2023)
Abstract Background Muscle wasting during cancer cachexia is mediated by protein degradation via autophagy and ubiquitin‐linked proteolysis. These processes are sensitive to changes in intracellular pH ([pH]i) and reactive oxygen species, which in
Externí odkaz:
https://doaj.org/article/c02fd9a25f77491299b8f06183dad31a
Autor:
Lorna Hopcroft, Eleanor M. Wigmore, Stuart C. Williamson, Susana Ros, Cath Eberlein, Jennifer I. Moss, Jelena Urosevic, Larissa S. Carnevalli, Sara Talbot, Lauren Bradshaw, Catherine Blaker, Sreeharsha Gunda, Venetia Owenson, Scott Hoffmann, Daniel Sutton, Stewart Jones, Richard J. A. Goodwin, Brandon S. Willis, Claire Rooney, Elza C. de Bruin, Simon T. Barry
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Combining the selective AKT inhibitor, capivasertib, and SERD, fulvestrant improved PFS in a Phase III clinical trial (CAPItello-291), treating HR+ breast cancer patients following aromatase inhibitors, with or without CDK4/6 inhibitors. How
Externí odkaz:
https://doaj.org/article/216706db2e6b4b6eae15d98244910c27
Autor:
Rosie R. Bisset, Peter W. Nienow, Daniel N. Goldberg, Oliver Wigmore, Raúl A. Loayza-Muro, Jemma L. Wadham, Moya L. Macdonald, Robert G. Bingham
Publikováno v:
Journal of Glaciology, Vol 69, Pp 981-996 (2023)
Supraglacial debris cover regulates the melt rates of many glaciers in mountainous regions around the world, thereby modifying the availability and quality of downstream water resources. However, the influence of supraglacial debris is often poorly r
Externí odkaz:
https://doaj.org/article/7189b659894f40e78c673c158aabe4fa
Autor:
Apiwat Sirichoat, Oabnithi Dornlakorn, Rasa Saenno, Anusara Aranarochana, Nataya Sritawan, Wanassanun Pannangrong, Peter Wigmore, Jariya Umka Welbat
Publikováno v:
Heliyon, Vol 10, Iss 5, Pp e26919- (2024)
l-methionine (L-met) is a substantial non-polar amino acid for normal development. L-met is converted to homocysteine that leads to hyperhomocysteinemia and subsequent excessive homocysteine in serum resulting in stimulating oxidative stress and vasc
Externí odkaz:
https://doaj.org/article/66fe694bcfed491ba14c160446f6c0d5
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