External validation of the Leiden Thrombosis Recurrence Risk Prediction models (L-TRRiP) for the prediction of recurrence after a first venous thrombosis in the Heart and Vascular Health study.

Autor: Burggraaf-van Delft JLI; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Wiggins KL; Department of Medicine, University of Washington, Seattle, Washington, USA., van Rein N; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands., le Cessie S; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands., Smith NL; Department of Epidemiology, University of Washington, Seattle, Washington, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.; Department of Veterans Affairs Office of Research and Development, Seattle Epidemiologic Research and Information Center, Seattle, Washington, USA., Cannegieter SC; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Medicine - Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands.

Publikováno v: Research and practice in thrombosis and haemostasis [Res Pract Thromb Haemost] 2024 Oct 29; Vol. 8 (8), pp. 102610. Date of Electronic Publication: 2024 Oct 29 (Print Publication: 2024).

Epigenetic and proteomic signatures associate with clonal hematopoiesis expansion rate.

Autor: Mack TM; Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN, USA., Raddatz MA; Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Pershad Y; Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN, USA., Nachun DC; Department of Pathology, Stanford University, Stanford, CA, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Shuldiner AR; Department of Medicine, University of Maryland, Baltimore, Baltimore, MD, USA., O'Connell JR; Department of Medicine, University of Maryland, Baltimore, Baltimore, MD, USA., Kenny EE; Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Loos RJF; The Charles Bronfman Institute of Personalized Medicine, Mount Sinai Hospital, New York City, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Redline S; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Cade BE; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Silverman EK; Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA., Yun JH; Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA., Cho MH; Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA., DeMeo DL; Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA., Levy D; National Heart, Lung and Blood Institute, Population Sciences Branch, Framingham, MA, USA., Johnson AD; National Heart, Lung and Blood Institute, Population Sciences Branch, Framingham, MA, USA., Mathias RA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Yanek LR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Heckbert SR; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA., Smith NL; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.; Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, WA, USA., Wiggins KL; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Carson AP; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Manichaikul AW; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Gu CC; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA., Chen YI; Medical Genetics Translational Genomics and Population Sciences (TGPS), Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA., Lee WJ; Department of Medical Research, Taichung Veterans General Hospital, Taichung City, Taiwan., Shoemaker MB; Division of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA., Roden DM; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University, Nashville, TN, USA., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Auer PL; Division of Biostatistics, Institute for Health and Equity, and Cancer Center, Medical College of Wisconsin, Milwaukee, WI, USA., Desai P; Division of Hematology and Oncology, Weill Cornell Medicine, New York, NY, USA.; Englander Institute of Precision Medicine, Weill Cornell Medicine, New York, NY, USA., Blackwell TW; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Smith AV; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Reiner AP; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Jaiswal S; Department of Pathology, Stanford University, Stanford, CA, USA., Weinstock JS; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Bick AG; Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN, USA. alexander.bick@vumc.org.; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. alexander.bick@vumc.org.

Publikováno v: Nature aging [Nat Aging] 2024 Aug; Vol. 4 (8), pp. 1043-1052. Date of Electronic Publication: 2024 Jun 04.

Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes.

Autor: Kwak SH; Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA., Hernandez-Cancela RB; Department of Biostatistics, Boston University School of Public Health, Boston, MA., DiCorpo DA; Department of Biostatistics, Boston University School of Public Health, Boston, MA., Condon DE; Sanford Imagenetics, Sanford Health, Sioux Falls, SD., Merino J; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Wu P; Department of Biostatistics, Boston University School of Public Health, Boston, MA., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA., Yao J; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA., Guo X; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA., Ahmadizar F; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Department of Data Science and Biostatistics, Julius Global Health, University Medical Center Utrecht, Utrecht, the Netherlands., Meyer M; Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO., Sincan M; Department of Biostatistics, Boston University School of Public Health, Boston, MA., Mercader JM; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA., Lee S; Division of Vascular Surgery and Endovascular Therapy, Massachusetts General Hospital, Boston, MA., Haessler J; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA., Vy HMT; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Lin Z; Department of Biostatistics, University of Minnesota, Minneapolis, MN., Armstrong ND; Department of Epidemiology, The University of Alabama at Birmingham, Birmingham, AL., Gu S; Department of Internal Medicine, Sanford Health, Sioux Falls, SD., Tsao NL; Corporal Michael J. Crescenz VA Medical Center and Department of Surgery, Perelman School of Medicine, Philadelphia, PA., Lange LA; Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO., Wang N; Department of Biostatistics, Boston University School of Public Health, Boston, MA., Wiggins KL; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA., Trompet S; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands., Liu S; Department of Epidemiology, Brown University, Providence, RI., Loos RJF; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Judy R; Corporal Michael J. Crescenz VA Medical Center and Department of Surgery, Perelman School of Medicine, Philadelphia, PA., Schroeder PH; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA., Hasbani NR; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX., Bos MM; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX., Jackson RD; Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Ohio State University, Columbus, OH., Reiner AP; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA.; Department of Epidemiology, University of Washington, Seattle, WA., Manson JE; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Chaudhary NS; Department of Epidemiology, The University of Alabama at Birmingham, Birmingham, AL., Carmichael LK; Department of Internal Medicine, Sanford Health, Sioux Falls, SD., Chen YI; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA., Taylor KD; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA., Ghanbari M; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., van Meurs J; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Pitsillides AN; Department of Biostatistics, Boston University School of Public Health, Boston, MA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.; Department of Epidemiology, University of Washington, Seattle, WA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA., Noordam R; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands., Do R; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Park KS; Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Netherlands Heart Institute, Utrecht, the Netherlands., Kavousi M; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, MS., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA., Damrauer SM; Corporal Michael J. Crescenz VA Medical Center and Department of Surgery, Perelman School of Medicine, Philadelphia, PA.; Department of Genetics, Perelman School of Medicine, Philadelphia, PA., Hajek C; Department of Internal Medicine, Sanford Health, Sioux Falls, SD., Cho NH; Department of Preventive Medicine, Ajou University School of Medicine, Suwon, Korea., Irvin MR; Department of Epidemiology, The University of Alabama at Birmingham, Birmingham, AL., Pankow JS; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN., Nadkarni GN; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Sladek R; Department of Medicine and Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Goodarzi MO; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA., Florez JC; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA., Chasman DI; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Heckbert SR; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.; Department of Epidemiology, University of Washington, Seattle, WA., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada., Malhotra R; Cardiovascular Research Center, Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA., de Vries PS; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA., Rotter JI; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA., Meigs JB; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; Department of General Internal Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, MA.

Publikováno v: Diabetes care [Diabetes Care] 2024 Jun 01; Vol. 47 (6), pp. 1042-1047.

Combining high quality data with rigorous methods: emulation of a target trial using electronic health records and a nested case-control design.

Autor: Rasouli B; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Department of Global Health and Population, Harvard TH Chan School of Public Health, Boston, MA 02115, USA., Chubak J; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Floyd JS; Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA, USA., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA., Nguyen M; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Walker RL; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Wiggins KL; Department of Medicine, University of Washington, Seattle, WA, USA., Logan RW; Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA., Danaei G; Department of Global Health and Population, Harvard TH Chan School of Public Health, Boston, MA 02115, USA gdanaei@hsph.harvard.edu.; Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.; CAUSALab, Harvard TH Chan School of Public Health, Boston, MA, USA.

Publikováno v: BMJ (Clinical research ed.) [BMJ] 2023 Dec 28; Vol. 383, pp. e072346. Date of Electronic Publication: 2023 Dec 28.

Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus (vol 13, 1222, 2022)

Autor: Stacey, D, Chen, LY, Stanczyk, PJ, Howson, JMM, Mason, AM, Burgess, S, MacDonald, S, Langdown, J, McKinney, H, Downes, K, Farahi, N, Peters, JE, Basu, S, Pankow, JS, Tang, WH, Pankratz, N, Sabater-Lleal, M, de Vries, PS, Smith, NL, Dehghan, A, Heath, AS, Morrison, AC, Reiner, AP, Johnson, A, Richmond, A, Peters, A, Vlieg, AV, McKnight, B, Psaty, BM, Hayward, C, Ward-Caviness, C, O'Donnell, C, Chasman, D, Strachan, DP, Tregouet, DA, Mook-Kanamori, D, Gill, D, Thibord, F, Asselbergs, FW, Leebeek, FWG, Rosendaal, FR, Davies, G, Homuth, G, Temprano, G, Campbell, H, Taylor, HA, Bressler, J, Huffman, JE, Rotter, JI, Yao, J, Wilson, JF, Bis, JC, Hahn, JM, Desch, KC, Wiggins, KL, Raffield, LM, Bielak, LF, Yanek, LR, Kleber, ME, Mueller, M, Kavousi, M, Mangino, M, Conomos, MP, Liu, ML, Brown, MR, Jhun, MA, Chen, MH, de Maat, MPM, Peyser, PA, Elliot, P, Wei, P, Wild, PS, Morange, PE, van der Harst, P, Yang, Q, Le, NQ, Marioni, R, Li, RF, Damrauer, SM, Cox, SR, Trompet, S, Felix, SB, Volker, U, Koenig, W, Jukema, JW, Guo, XQ, Gelinas, AD, Schneider, DJ, Janjic, N, Samani, NJ, Ye, S, Summers, C, Chilvers, ER, Danesh, J, Paul, DS

Publikováno v: Nature Communications
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