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pro vyhledávání: '"Wiggins, Paul"'
Autor:
Choi, H. James, Lo, Teresa W., Cutler, Kevin J., Huang, Dean, Will, W. Ryan, Wiggins, Paul A.
Protein expression levels optimize cell fitness: Too low an expression level of essential proteins will slow growth by compromising essential processes; whereas overexpression slows growth by increasing the metabolic load. This trade-off naively pred
Externí odkaz:
http://arxiv.org/abs/2408.11952
Autor:
Kazi, Zeeshawn, Shelby, Isaac M., Nirodi, Ruhee, Turnbull, Joseph, Watanabe, Hideyuki, Itoh, Kohei M., Wiggins, Paul A., Fu, Kai-Mei C.
DNA flexibility is a key determinant of biological function, from nucleosome positioning to transcriptional regulation, motivating a direct measurement of the bend-torque response of individual DNA molecules. In this work, DNA bending is detected usi
Externí odkaz:
http://arxiv.org/abs/2402.17964
The processes of gene expression are inherently stochastic, even for essential genes required for growth. How does the cell maximize fitness in light of noise? To answer this question, we build a mathematical model to explore the trade-off between me
Externí odkaz:
http://arxiv.org/abs/2310.13803
The inherent stochasticity of cellular processes leads to significant cell-to-cell variation in protein abundance. Although this noise has already been characterized and modeled, its broader implications and significance remain unclear. In this paper
Externí odkaz:
http://arxiv.org/abs/2307.03324
An important step towards understanding the mechanistic basis of the central dogma is the quantitative characterization of the dynamics of nucleic-acid-bound molecular motors in the context of the living cell, where a crowded cytoplasm as well as com
Externí odkaz:
http://arxiv.org/abs/2208.06775
Publikováno v:
Phys. Rev. E 105, 014420 (2022)
Two powerful and complementary experimental approaches are commonly used to study the cell cycle and cell biology: One class of experiments characterizes the statistics (or demographics) of an unsynchronized exponentially-growing population, while th
Externí odkaz:
http://arxiv.org/abs/2108.10988
Autor:
Kazi, Zeeshawn, Shelby, Isaac M., Watanabe, Hideyuki, Itoh, Kohei M., Shutthanandan, Vaithiyalingam, Wiggins, Paul A., Fu, Kai-Mei C.
Publikováno v:
Phys. Rev. Applied 15, 054032 (2021)
Wide-field magnetometry can be realized by imaging the optically-detected magnetic resonance of diamond nitrogen vacancy (NV) center ensembles. However, NV ensemble inhomogeneities significantly limit the magnetic-field sensitivity of these measureme
Externí odkaz:
http://arxiv.org/abs/2002.06237
Akademický článek
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Autor:
LaMont, Colin H., Wiggins, Paul A.
Publikováno v:
Phys. Rev. E 99, 052140 (2019)
We expand upon a natural analogy between Bayesian statistics and statistical physics in which sample size corresponds to inverse temperature. This analogy motivates the definition of two novel statistical quantities: a learning capacity and a Gibbs e
Externí odkaz:
http://arxiv.org/abs/1706.01428
Autor:
LaMont, Colin H., Wiggins, Paul A.
There are three principle paradigms of statistics: Bayesian, frequentist and information-based inference. Although these paradigms are in agreement in some contexts, the Lindley paradox describes a class of problems, models of unknown dimension, wher
Externí odkaz:
http://arxiv.org/abs/1610.09433