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The human liver microenvironment shapes the homing and function of CD4⁺ T-cell populations.

Autor: Wiggins, Benjamin G., Pallett, Laura J., Xiaoyan Li, Davies, Scott P., Amin, Oliver E., Gill, Upkar S., Kucykowicz, Stephanie, Patel, Arzoo M., Aliazis, Konstantinos, Liu, Yuxin S., Reynolds, Gary M., Davidson, Brian R., Gander, Amir, Tu Vinh Luong, Hirschfield, Gideon M., Kennedy, Patrick T. F., Yuehua Huang, Maini, Mala K., Stamataki, Zania

Publikováno v: Gut; Jul2022, Vol. 71 Issue 7, p1399-1411, 13p

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The human liver microenvironment shapes the homing and function of CD4 ⁺ T-cell populations.

Autor: Wiggins BG; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.; Institute of Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK.; Centre for Liver and Gastrointestinal Research, University of Birmingham, Birmingham, UK., Pallett LJ; Institute of Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK., Li X; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.; Department of Infectious Diseases and Guangdong Provincial Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Davies SP; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.; Centre for Liver and Gastrointestinal Research, University of Birmingham, Birmingham, UK., Amin OE; Institute of Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK., Gill US; Immunobiology, Blizard Institute, London, UK., Kucykowicz S; Institute of Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK., Patel AM; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.; Centre for Liver and Gastrointestinal Research, University of Birmingham, Birmingham, UK., Aliazis K; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.; Centre for Liver and Gastrointestinal Research, University of Birmingham, Birmingham, UK., Liu YS; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.; Centre for Liver and Gastrointestinal Research, University of Birmingham, Birmingham, UK., Reynolds GM; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.; Centre for Liver and Gastrointestinal Research, University of Birmingham, Birmingham, UK., Davidson BR; Surgery, Royal Free Campus, UCL Medical School, London, UK., Gander A; Tissue Access for Patient Benefit, University College London, London, UK., Luong TV; Department of Cellular Pathology, Royal Free Hospital, London, UK., Hirschfield GM; Centre for Liver and Gastrointestinal Research, University of Birmingham, Birmingham, UK.; Centre for Liver Research, National Institute for Health Research Biomedical Research Unit, University of Birmingham, Birmingham, UK., Kennedy PTF; Immunobiology, Blizard Institute, London, UK., Huang Y; Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.; Guangdong Provincial Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China., Maini MK; Division of Infection and Immunity, Rayne Institute, University College London, London, UK z.stamataki@bham.ac.uk m.maini@ucl.ac.uk., Stamataki Z; Centre for Liver and Gastrointestinal Research, University of Birmingham, Birmingham, UK z.stamataki@bham.ac.uk m.maini@ucl.ac.uk.

Publikováno v: Gut [Gut] 2022 Jul; Vol. 71 (7), pp. 1399-1411. Date of Electronic Publication: 2021 Sep 21.

In Vitro and Ex Vivo Models to Study T Cell Migration Through the Human Liver Parenchyma.

Autor: Wiggins BG; Centre for Liver Research, Immunity and Immunotherapy, Institute of Biomedical Research, University of Birmingham, Birmingham, B15 2TT, UK., Aliazis K; Centre for Liver Research, Institute for Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK., Davies SP; Centre for Liver Research, Institute for Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK., Hirschfield G; Centre for Liver Research, Institute for Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK., Lalor PF; Centre for Liver Research, Immunity and Immunotherapy, Institute of Biomedical Research, University of Birmingham, Birmingham, B15 2TT, UK., Reynolds G; Centre for Liver Research, Institute for Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK., Stamataki Z; Centre for Liver Research, Immunity and Immunotherapy, Institute of Biomedical Research, University of Birmingham, Birmingham, B15 2TT, UK. z.stamataki@bham.ac.uk.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2017; Vol. 1591, pp. 195-214.