Zobrazeno 1 - 10
of 359
pro vyhledávání: '"Wifredo Ricart"'
Autor:
Aina Lluch, Jessica Latorre, Angela Serena-Maione, Isabel Espadas, Estefanía Caballano-Infantes, José M. Moreno-Navarrete, Núria Oliveras-Cañellas, Wifredo Ricart, María M. Malagón, Alejandro Martin-Montalvo, Walter Birchmeier, Witold Szymanski, Johannes Graumann, María Gómez-Serrano, Elena Sommariva, José M. Fernández-Real, Francisco J. Ortega
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Plakophilin-2 (PKP2) is a key component of desmosomes, which, when defective, is known to promote the fibro-fatty infiltration of heart muscle. Less attention has been given to its role in adipose tissue. We report here that levels of PKP2 s
Externí odkaz:
https://doaj.org/article/c9aab534331a4f3fa90b32b90c48e65f
Autor:
Jessica Latorre, Ramon Díaz-Trelles, Ferran Comas, Aleix Gavaldà-Navarro, Edward Milbank, Nathalia Dragano, Samantha Morón-Ros, Rajesh Mukthavaram, Francisco Ortega, Anna Castells-Nobau, Núria Oliveras-Cañellas, Wifredo Ricart, Priya P. Karmali, Kiyoshi Tachikawa, Pad Chivukula, Francesc Villarroya, Miguel López, Marta Giralt, José Manuel Fernández-Real, José María Moreno-Navarrete
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 599-613 (2022)
Circulating lipopolysaccharide-binding protein (LBP) is increased in individuals with liver steatosis. We aimed to evaluate the possible impact of liver LBP downregulation using lipid nanoparticle-containing chemically modified LBP small interfering
Externí odkaz:
https://doaj.org/article/2318b693c0cb490ab904a421bf554622
Autor:
Jessica Latorre, Francisco Ortega, Núria Oliveras-Cañellas, Ferran Comas, Aina Lluch, Aleix Gavaldà-Navarro, Samantha Morón-Ros, Wifredo Ricart, Francesc Villarroya, Marta Giralt, José Manuel Fernández-Real, José María Moreno-Navarrete
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 870-879 (2022)
Lipopolysaccharide binding protein (Lbp) has been recently identified as a relevant component of innate immunity response associated to adiposity. Here, we aimed to investigate the impact of adipose tissue Lbp on weight gain and white adipose tissue
Externí odkaz:
https://doaj.org/article/f9dbfee1ff5c4a26b586d69304553e65
Autor:
Jèssica Latorre, Cristina Martínez, Francisco Ortega, Núria Oliveras-Cañellas, Francisco Díaz-Sáez, Julian Aragonés, Marta Camps, Anna Gumà, Wifredo Ricart, José Manuel Fernández-Real, José María Moreno-Navarrete
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 156, Iss , Pp 113972- (2022)
Objective: To investigate the potential role of EGFR, ErbBs receptors and neuregulins in human adipose tissue physiology in obesity. Methods: Gene expression analysis in human subcutaneous (SAT) and visceral (VAT) adipose tissue in three independent
Externí odkaz:
https://doaj.org/article/d01dae50602f4a4689f0e10ec081498a
Autor:
Cristina Martínez, Jèssica Latorre, Francisco Ortega, María Arnoriaga-Rodríguez, Aina Lluch, Núria Oliveras-Cañellas, Francisco Díaz-Sáez, Julian Aragonés, Marta Camps, Anna Gumà, Wifredo Ricart, José Manuel Fernández-Real, José María Moreno-Navarrete
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Neuregulin 4 (NRG4) has been described to improve metabolic disturbances linked to obesity status in rodent models. The findings in humans are controversial. We aimed to investigate circulating NRG4 in association with insulin action in humans and th
Externí odkaz:
https://doaj.org/article/12e2abad95514b38acec114a873da90c
Autor:
Ferran Comas, Ramon Díaz-Trelles, Aleix Gavaldà-Navarro, Edward Milbank, Nathalia Dragano, Samantha Morón-Ros, Rajesh Mukthavaram, Jessica Latorre, Francisco Ortega, Maria Arnoriaga-Rodriguez, Núria Oliveras-Cañellas, Wifredo Ricart, Priya P. Karmali, Kiyoshi Tachikawa, Pad Chivukula, Francesc Villarroya, Marta Giralt, Miguel López, José Manuel Fernández-Real, José María Moreno-Navarrete
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 151, Iss , Pp 113156- (2022)
Background and aims: The sexual dimorphism in fat-mass distribution and circulating leptin and insulin levels is well known, influencing the progression of obesity-associated metabolic disease. Here, we aimed to investigate the possible role of lipop
Externí odkaz:
https://doaj.org/article/aa1f1e08da414ca3b75ee9401097de0f
Autor:
Jordi Mayneris-Perxachs, Marina Cardellini, Lesley Hoyles, Jèssica Latorre, Francesca Davato, José Maria Moreno-Navarrete, María Arnoriaga-Rodríguez, Matteo Serino, James Abbott, Richard H. Barton, Josep Puig, Xavier Fernández-Real, Wifredo Ricart, Christopher Tomlinson, Mark Woodbridge, Paolo Gentileschi, Sarah A. Butcher, Elaine Holmes, Jeremy K. Nicholson, Vicente Pérez-Brocal, Andrés Moya, Donald Mc Clain, Rémy Burcelin, Marc-Emmanuel Dumas, Massimo Federici, José-Manuel Fernández-Real
Publikováno v:
Microbiome, Vol 9, Iss 1, Pp 1-18 (2021)
Abstract Background The gut microbiome and iron status are known to play a role in the pathophysiology of non-alcoholic fatty liver disease (NAFLD), although their complex interaction remains unclear. Results Here, we applied an integrative systems m
Externí odkaz:
https://doaj.org/article/7c2fb72a7230495f8f01f05ab72437fc
Autor:
Rossella Menghini, Lesley Hoyles, Marina Cardellini, Viviana Casagrande, Arianna Marino, Paolo Gentileschi, Francesca Davato, Maria Mavilio, Ivan Arisi, Alessandro Mauriello, Manuela Montanaro, Manuel Scimeca, Richard H. Barton, Francesca Rappa, Francesco Cappello, Manlio Vinciguerra, José Maria Moreno-Navarrete, Wifredo Ricart, Ottavia Porzio, José-Manuel Fernández-Real, Rémy Burcelin, Marc-Emmanuel Dumas, Massimo Federici
Publikováno v:
Molecular Metabolism, Vol 59, Iss , Pp 101454- (2022)
Objective: Metabolic syndrome, obesity, and steatosis are characterized by a range of dysregulations including defects in ubiquitin ligase tagging proteins for degradation. The identification of novel hepatic genes associated with fatty liver disease
Externí odkaz:
https://doaj.org/article/fc2aaa53cf464cd69ac7fa8f6d570d4f
A microRNA Cluster Controls Fat Cell Differentiation and Adipose Tissue Expansion By Regulating SNCG
Autor:
Ruth Rodríguez‐Barrueco, Jessica Latorre, Laura Devis‐Jáuregui, Aina Lluch, Nuria Bonifaci, Francisco J. Llobet, Mireia Olivan, Laura Coll‐Iglesias, Katja Gassner, Meredith L. Davis, José M. Moreno‐Navarrete, Anna Castells‐Nobau, Laura Plata‐Peña, Miki Dalmau‐Pastor, Marcus Höring, Gerhard Liebisch, Vesa M. Olkkonen, Maria Arnoriaga‐Rodríguez, Wifredo Ricart, José M. Fernández‐Real, José M. Silva, Francisco J. Ortega, David Llobet‐Navas
Publikováno v:
Advanced Science, Vol 9, Iss 4, Pp n/a-n/a (2022)
Abstract The H19X‐encoded miR‐424(322)/503 cluster regulates multiple cellular functions. Here, it is reported for the first time that it is also a critical linchpin of fat mass expansion. Deletion of this miRNA cluster in mice results in obesity
Externí odkaz:
https://doaj.org/article/e3f63b7bc662455caa34ba1b1fa999a2
Autor:
María Arnoriaga-Rodríguez, Jordi Mayneris-Perxachs, Aurelijus Burokas, Vicente Pérez-Brocal, Andrés Moya, Manuel Portero-Otin, Wifredo Ricart, Rafael Maldonado, José-Manuel Fernández-Real
Publikováno v:
Microbiome, Vol 8, Iss 1, Pp 1-10 (2020)
Abstract Background The chaperone ClpB, a bacterial protein, is a conformational antigen-mimetic of α-melanocyte-stimulating hormone (α-MSH) implicated in body weight regulation in mice. We here investigated the potential associations of gut bacter
Externí odkaz:
https://doaj.org/article/9743bb5719b149bea9b8999d1331a269