WIF-1 contributes to lupus-induced neuropsychological deficits via the CRYAB/STAT4-SHH axis

Autor: Liping Tan, Yu Fan, Xinyi Xu, Tianshu Zhang, Xiangyu Cao, Chenghao Zhang, Jun Liang, Yayi Hou, Huan Dou

Publikováno v: Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-20 (2024)

Abstract Background Neuropsychiatric systemic lupus erythematosus (NPSLE) often manifests as cognitive deterioration, with activated microglia and blood-brain barrier (BBB) disruption implicated in these neurological complications. Wnt-inhibitory fac

Externí odkaz: https://doaj.org/article/379656e75aa446f5b544b39a683e0406

WIF-1 contributes to lupus-induced neuropsychological deficits via the CRYAB/STAT4-SHH axis.

Autor: Tan L; The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing, 210093, China.; Jiangsu Key Laboratory of Molecular Medicine, Nanjing, 210093, China., Fan Y; The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing, 210093, China.; Jiangsu Key Laboratory of Molecular Medicine, Nanjing, 210093, China., Xu X; Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China., Zhang T; The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing, 210093, China.; Jiangsu Key Laboratory of Molecular Medicine, Nanjing, 210093, China., Cao X; The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing, 210093, China.; Jiangsu Key Laboratory of Molecular Medicine, Nanjing, 210093, China., Zhang C; The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing, 210093, China.; Jiangsu Key Laboratory of Molecular Medicine, Nanjing, 210093, China., Liang J; Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China. 13505193169@139.com., Hou Y; The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing, 210093, China. yayihou@nju.edu.cn.; Jiangsu Key Laboratory of Molecular Medicine, Nanjing, 210093, China. yayihou@nju.edu.cn., Dou H; The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing, 210093, China. douhuan@nju.edu.cn.; Jiangsu Key Laboratory of Molecular Medicine, Nanjing, 210093, China. douhuan@nju.edu.cn.

Publikováno v: Arthritis research & therapy [Arthritis Res Ther] 2024 Oct 23; Vol. 26 (1), pp. 183. Date of Electronic Publication: 2024 Oct 23.

A long non-coding RNA, HOTAIR, promotes cartilage degradation in osteoarthritis by inhibiting WIF-1 expression and activating Wnt pathway.

Autor: Yang, Yang¹ (AUTHOR), Xing, Dan² (AUTHOR), Wang, Yawei³ (AUTHOR), Jia, Haobo¹ (AUTHOR), Li, Bing¹ (AUTHOR), Li, Jiao Jiao^4,5 (AUTHOR) jiaojiao.li@sydney.edu.au

Publikováno v: BMC Molecular & Cell Biology. 7/10/2020, Vol. 21 Issue 1, p1-11. 11p.

Indirubin inhibits Wnt/β-catenin signal pathway via promoter demethylation of WIF-1

Autor: Shou Gang Liu, Guang Pu Luo, Yong Bin Qu, Yong Feng Chen

Publikováno v: BMC Complementary Medicine and Therapies, Vol 20, Iss 1, Pp 1-10 (2020)

Abstract Background Psoriasis is a common inflammatory skin disease. Abnormal proliferation of keratinocytes is one of the psoriatic histopathological features. Indirubin has an essential effect on the proliferation and activation of keratinocytes; h

Externí odkaz: https://doaj.org/article/d54bb1d394fd44a59cc7a716fba8259d

Elevated plasma WIF‐1 levels are associated with worse prognosis in heart failure with pulmonary hypertension

Autor: Kriss Kania, Abdulla Ahmed, Salaheldin Ahmed, Göran Rådegran

Publikováno v: ESC Heart Failure, Vol 9, Iss 6, Pp 4139-4149 (2022)

Abstract Aims Heart failure (HF) is a progressive condition that is becoming more prevalent in the ageing population. Pulmonary hypertension is a common complicating factor in HF and negatively impacts survival. Plasma biomarkers are a potential meth

Externí odkaz: https://doaj.org/article/de5e3e8f704d4f66a705bcea46f2f210