Effectiveness of First-Line Treatment With Recombinant Interleukin-1 Receptor Antagonist in Steroid-Naive Patients With New-Onset Systemic Juvenile Idiopathic Arthritis: Results of a Prospective Cohort Study

Autor: Bo Jan Noordman, Dirk Holzinger, Sebastiaan J. Vastert, Nico M Wulffraat, Wilco de Jager, Berent J. Prakken, Wietse Kuis

Publikováno v: Arthritis & Rheumatology. 66:1034-1043

Objective To conduct a prospective cohort study using anakinra, a recombinant IL-1 receptor antagonist (IL-1Ra), as first-line therapy in patients with new-onset systemic juvenile idiopathic arthritis (JIA). Methods Therapy with recombinant IL-1Ra (2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a96d4712fd632f5e455efa31f75332d
https://doi.org/10.1002/art.38296

Health and identity: Self-positioning in adolescent chronic fatigue syndrome and juvenile idiopathic arthritis

Autor: Gerben Sinnema, Coralie E. Fuchs, Rolf van Geel, Stefan M. Van Geelen, Wietse Kuis, Elise M. van de Putte, Hubert J. M. Hermans

Publikováno v: Clinical Child Psychology and Psychiatry. 18:383-397

The aim of this study is to gain more insight into basic aspects of identity, in relation to adolescent chronic fatigue syndrome (CFS) and juvenile idiopathic arthritis (JIA). In dialogical self theory, identity is regarded as incorporating multiple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b70835c598b11d9d0a76b984b89b059
https://doi.org/10.1177/1359104512455814

FOXP3+CD4+ Tregs lose suppressive potential but remain anergic during transient inflammation in human

Autor: Fabiola C M Evens, Nicolaas J. G. Jansen, Sebastiaan J. Vastert, Adrianus J. van Vught, Alvin W. L. Schadenberg, Wietse Kuis, Berent J. Prakken

Publikováno v: European Journal of Immunology. 41:1132-1142

Tregs are crucial in controlling inflammation. Although the transcription factor FOXP3 is the most applicable phenotype marker of Tregs, it does not indisputably characterize suppressive function during T-cell activation in vitro. A question that rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2116093552b1f1e9da1be2c414fdf52a
https://doi.org/10.1002/eji.201040363

Defective phosphorylation of interleukin-18 receptor β causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis

Autor: Paul J. Coffer, Wilco de Jager, Berent J. Prakken, Wietse Kuis, Nico M Wulffraat, Jeffrey M. Beekman, Sebastiaan J. Vastert

Publikováno v: Arthritis & Rheumatism. 60:2782-2793

Objective. Systemic-onset juvenile idiopathic arthritis (JIA) is an autoimmune disease characterized by arthritis and systemic features. Its pathogenesis is still largely unknown. It is characterized immunologically by natural killer (NK) cell dysfun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9500962ff6b3b53adf7142c995cec243
https://doi.org/10.1002/art.24750

Self-investigation to explore the impact of juvenile arthritis on adolescent life

Autor: Hubert J. M. Hermans, Wietse Kuis, Coralie E. Fuchs, Stefan M. van Geelen, Gerben Sinnema

Publikováno v: Fuchs, C E, Sinnema, G, van Geelen, S M, Hermans, H J M & Kuis, W 2008, ' Self-investigation to explore the impact of juvenile arthritis on adolescent life : A case-study ', Patient Education and Counseling, vol. 72, no. 1, pp. 163-167 . https://doi.org/10.1016/j.pec.2008.03.005
Patient Education and Counseling, 72(1), 163-167. Elsevier Ireland Ltd

Objective To gain insight into the personal experience and feelings of an adolescent with a chronic disease. Methods We report on the application of the self-confrontation method (SCM), illustrated by a case-example of an adolescent with juvenile idi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732a036fe9cf2b4841300887db2d8d11
https://doi.org/10.1016/j.pec.2008.03.005