Chaperone BiP controls ER stress sensor Ire1 through interactions with its oligomers.

Autor: Dawes S; https://ror.org/024mrxd33 School of Molecular and Cellular Biology, Faculty of Biological Sciences & Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK.; Chemistry Department, University of Sheffield, Sheffield, UK., Hurst N; https://ror.org/024mrxd33 School of Molecular and Cellular Biology, Faculty of Biological Sciences & Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK., Grey G; https://ror.org/024mrxd33 School of Molecular and Cellular Biology, Faculty of Biological Sciences & Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK., Wieteska L; https://ror.org/024mrxd33 School of Molecular and Cellular Biology, Faculty of Biological Sciences & Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK., Wright NV; https://ror.org/024mrxd33 School of Molecular and Cellular Biology, Faculty of Biological Sciences & Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK., Manfield IW; https://ror.org/024mrxd33 School of Molecular and Cellular Biology, Faculty of Biological Sciences & Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK., Hussain MH; https://ror.org/024mrxd33 School of Molecular and Cellular Biology, Faculty of Biological Sciences & Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK., Kalverda AP; https://ror.org/024mrxd33 School of Molecular and Cellular Biology, Faculty of Biological Sciences & Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK., Lewandowski JR; Department of Chemistry, University of Warwick, Coventry, UK., Chen B; Chemistry Department, University of Sheffield, Sheffield, UK., Zhuravleva A; https://ror.org/024mrxd33 School of Molecular and Cellular Biology, Faculty of Biological Sciences & Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK a.zhuravleva@leeds.ac.uk.

Publikováno v: Life science alliance [Life Sci Alliance] 2024 Aug 05; Vol. 7 (10). Date of Electronic Publication: 2024 Aug 05 (Print Publication: 2024).

An oncolytic virus-delivered TGFβ inhibitor overcomes the immunosuppressive tumor microenvironment.

Autor: DePeaux K; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Rivadeneira DB; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Lontos K; Stem Cell Transplantation and Cellular Therapy Center, The University of Texas, MD Anderson Cancer Center , Houston, TX, USA., Dean VG; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Gunn WG; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Watson MJ; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA., Yao T; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Wilfahrt D; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Hinck C; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Wieteska L; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Thorne SH; Kalivir Immunotherapeutics , Pittsburgh, PA, USA., Hinck AP; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Delgoffe GM; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2023 Oct 02; Vol. 220 (10). Date of Electronic Publication: 2023 Aug 08.

Targeting the Shc-EGFR interaction with indomethacin inhibits MAP kinase pathway signalling

Autor: Lin, C-C, Suen, KM, Stainthorp, A, Wieteska, L, Biggs, GS, Leitão, A, Montanari, CA, Ladbury, JE

Receptor tyrosine kinase (RTK)-mediated hyperactivation of the MAPK/Erk pathway is responsible for a large number of pathogenic outcomes including many cancers. Considerable effort has been directed at targeting this pathway with varying degrees of l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::c868e7e1a53686507fa49198ba48fb79
https://eprints.whiterose.ac.uk/146365/1/1-s2.0-S0304383519302915-main.pdf

Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state.

Autor: Lin CC; School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK. Electronic address: c.c.lin@leeds.ac.uk., Suen KM; School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK; Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK., Jeffrey PA; School of Mathematics, University of Leeds, Leeds LS2 9JT, UK., Wieteska L; School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK., Lidster JA; School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK., Bao P; School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, UK., Curd AP; School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK., Stainthorp A; School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK., Seiler C; School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK., Koss H; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, London WC1E 6BT, UK; Francis Crick Institute, London NW1 1AT, UK., Miska E; Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK., Ahmed Z; Department of Molecular and Cellular Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA., Evans SD; School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, UK., Molina-París C; School of Mathematics, University of Leeds, Leeds LS2 9JT, UK., Ladbury JE; School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK. Electronic address: j.e.ladbury@leeds.ac.uk.

Publikováno v: Molecular cell [Mol Cell] 2022 Mar 17; Vol. 82 (6), pp. 1089-1106.e12. Date of Electronic Publication: 2022 Feb 28.

44 Poster Discussion - Inhibition of 4NQO-induced oral squamous cell carcinoma progression by novel TGF-β inhibitors and PD-L1 antibodies

Autor: Ludwig, N. ¹, Yerneni, S.S. ², Azambuja, J.H. ³, Wieteska, Ł. ⁴, Hinck, C.S. ⁴, Bauer, R.J. ¹, Reichert, T.E. ¹, Hinck, A.P. ⁴, Whiteside, T.L. ³

Publikováno v: In European Journal of Cancer October 2020 138 Supplement 2:S19-S20