Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Wieteke A. M. Hoeijmakers"'
Autor:
Rob Henderson, Liwang Cui, Sabine Schmidt, Jun Miao, Christa Geeke Toenhake, Sonja Ghidelli-Disse, Jakob Birnbaum, Gerard Drewes, Sony Shrestha, Hendrik G. Stunnenberg, Tobias Spielmann, Richárd Bártfai, Jeron Venhuizen, Wieteke A. M. Hoeijmakers
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 47, 11574-11588
Nucleic Acids Research, 47, 22, pp. 11574-11588
Nucleic Acids Research, 47, 11574-11588
Nucleic Acids Research, 47, 22, pp. 11574-11588
Epigenetic regulatory mechanisms are central to the development and survival of all eukaryotic organisms. These mechanisms critically depend on the marking of chromatin domains with distinctive histone tail modifications (PTMs) and their recognition
Autor:
Wieteke A. M. Hoeijmakers, Alexandra Blancke Soares, Ulrike Fröhlke, Sabine Schmidt, Hendrik Herrmann, Paolo Mesén-Ramírez, Sven Flemming, Bärbel Bergmann, Sarah Scharf, Ernst Jonscher, Ricarda Sabitzki, Tobias Spielmann, Christa Geeke Toenhake, Jakob Birnbaum, Richárd Bártfai, Marius Schmitt
Publikováno v:
Science, 367, 6473, pp. 51-59
Science, 367, 51-59
Science, 367, 51-59
An artemisinin resistance mechanism Species of the malaria parasite Plasmodium live in red blood cells and possess a highly conserved gene called kelch13 . Single point mutations in this gene are associated with resistance to the frontline artemisini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee08cf2c64ddd134e53fa052b79c7763
https://hdl.handle.net/2066/216019
https://hdl.handle.net/2066/216019
Autor:
Richárd Bártfai, Wieteke A M Hoeijmakers, Adriana M Salcedo-Amaya, Arne H Smits, Eva Janssen-Megens, Anita Kaan, Moritz Treeck, Tim-Wolf Gilberger, Kees-Jan Françoijs, Hendrik G Stunnenberg
Publikováno v:
PLoS Pathogens, Vol 6, Iss 12, p e1001223 (2010)
Epigenetic regulatory mechanisms and their enzymes are promising targets for malaria therapeutic intervention; however, the epigenetic component of gene expression in P. falciparum is poorly understood. Dynamic or stable association of epigenetic mar
Externí odkaz:
https://doaj.org/article/1ab591b21aab42e8b8efacb89ad7b83c
Autor:
Matthew Berriman, Lia Chappell, Maaike Bras, Philip R. Kensche, Christa Geeke Toenhake, Wieteke A. M. Hoeijmakers, Richárd Bártfai
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 44, 5, pp. 2110-24
Nucleic Acids Research, 44, 2110-24
Nucleic Acids Research, 44, 5, pp. 2110-24
Nucleic Acids Research, 44, 2110-24
In eukaryotes, the chromatin architecture has a pivotal role in regulating all DNA-associated processes and it is central to the control of gene expression. For Plasmodium falciparum, a causative agent of human malaria, the nucleosome positioning pro
Autor:
Wieteke A. M. Hoeijmakers, Kees-Jan Francoijs, Adriana M. Salcedo-Amaya, Moritz Treeck, Richárd Bártfai, Tim-Wolf Gilberger, Arne H. Smits, Hendrik G. Stunnenberg
Publikováno v:
Molecular Microbiology. 87:1061-1073
Summary Histone variants are key components of the epigenetic code and evolved to perform specific functions in transcriptional regulation, DNA repair, chromosome segregation and other fundamental processes. Although variants for histone H2A and H3 a
Publikováno v:
Trends in Parasitology, 28, 11, pp. 486-495
Trends in Parasitology; Vol 28
Trends in Parasitology, 28, 486-495
Trends in Parasitology; Vol 28
Trends in Parasitology, 28, 486-495
It is becoming increasingly evident that epigenetic mechanisms that act on and regulate chromatin structure play a key role in the development, adaptation, and survival of the malaria parasite within its human host. The study of epigenetics in Plasmo
Autor:
Teun Bousema, Annet Italiaander, Edwin Lasonder, Ben C. L. van Schaijk, Chris J. Janse, Shahid M. Khan, Rob Woestenenk, Philip R. Kensche, Sanna R. Rijpma, Wieteke A. M. Hoeijmakers, Gunnar R. Mair, Martijn W. Vos, Richárd Bártfai, Robert W. Sauerwein, Mark S. Gresnigt
Publikováno v:
Nucleic Acids Research, 44, 13, pp. 6087-101
Nucleic Acids Research
Nucleic Acids Research, 44, 6087-101
Nucleic Acids Research, 44(13), 6087-6101
Nucleic Acids Research
Nucleic Acids Research, 44, 6087-101
Nucleic Acids Research, 44(13), 6087-6101
Contains fulltext : 167311.pdf (Publisher’s version ) (Open Access) Sexual differentiation of malaria parasites into gametocytes in the vertebrate host and subsequent gamete fertilization in mosquitoes is essential for the spreading of the disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dbbd0d486c86bf44af23ec83f9827d1
https://doi.org/10.1093/nar/gkw536
https://doi.org/10.1093/nar/gkw536
Autor:
Kees-Jan Francoijs, Wieteke A. M. Hoeijmakers, Jennifer Volz, Alan F. Cowman, Hendrik G. Stunnenberg, Till S. Voss, Johanna Wetzel, Christian Flueck, Richárd Bártfai, Arne H. Smits
Publikováno v:
Cellular Microbiology. 14:1391-1401
Centromeres are essential for the faithful transmission of chromosomes to the next generation, therefore being essential in all eukaryotic organisms. The centromeres of Plasmodium falciparum, the causative agent of the most severe form of malaria, ha
Autor:
Wieteke A M, Hoeijmakers, Christian, Flueck, Kees-Jan, Françoijs, Arne H, Smits, Johanna, Wetzel, Jennifer C, Volz, Alan F, Cowman, Till, Voss, Hendrik G, Stunnenberg, Richárd, Bártfai
Publikováno v:
Cellular Microbiology; Vol 14
Cellular microbiology
Cellular microbiology
Centromeres are essential for the faithful transmission of chromosomes to the next generation, therefore being essential in all eukaryotic organisms. The centromeres of Plasmodium falciparum, the causative agent of the most severe form of malaria, ha
Autor:
Eric Campeau, Albert R. Davalos, Francis Rodier, Jean-Philippe Coppe, Saba R. Raza, Wieteke A. M. Hoeijmakers, Judith Campisi, Christopher K. Patil, Adam Freund, Denise P. Muñoz
Publikováno v:
Nature cell biology
Cellular senescence suppresses cancer by stably arresting the proliferation of damaged cells. Paradoxically, senescent cells also secrete factors that alter tissue microenvironments. The pathways regulating this secretion are unknown. We show that da