Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Wieslaw K. Dowjat"'
1
Inhibition of neurite outgrowth by familial Alzheimer's disease-linked presenilin-1 mutations
Autor: Henryk M. Wisniewski, Spiros Efthimiopoulos, Wieslaw K. Dowjat, Thomas Wisniewski
Publikováno v: Neuroscience Letters. 267:141-144
Two (P117L; M146L) familial Alzheimer's disease (FAD)-causing presenilin-1 (PS1) mutations have been tested fortheir effect in stably transfected mouse neuroblastoma (N2a) cell lines. The P117L mutation is associated with the earliest onset of AD rep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7083057dd1ccd61ae45eaf2d8244c0e8
https://doi.org/10.1016/s0304-3940(99)00351-1
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2
Intracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A)
Autor: Giorgio Albertini, Ausma Rabe, Jerzy Wegiel, Pankaj Mehta, Madhabi Barua, Wojciech Kaczmarski, Wieslaw K. Dowjat, David C. Bolton, Bozena Mazur-Kolecka, Yu Wen Hwang, Janusz Frackowiak
Publikováno v: Journal of neuroscience research. 92(2)
The gene encoding dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is located within the Down syndrome (DS) critical region of chromosome 21. DYRK1A interacts with a plethora of substrates in the cytosol, cytoskeleton, and nucle
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9403768299d1c2d381ffc39222aaef00
https://pubmed.ncbi.nlm.nih.gov/24327345
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3
Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome
Autor: Wieslaw K. Dowjat, Yu Wen Hwang, Sonia Palminiello, Krzysztof Nowicki, Izabela Kuchna, Tatyana Adayev, Jerzy Wegiel
Publikováno v: Neuroscience letters. 413(1)
Down syndrome (DS) is the most common genetic disorder associated with mental retardation (MR). It is believed that many of the phenotypic features of DS stem from enhanced expression of a set of genes located within the triplicated region on chromos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3f06231f5346ad862de7f8dd87b44c
https://pubmed.ncbi.nlm.nih.gov/17145134
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4
A novel highly pathogenic Alzheimer presenilin-1 mutation in codon 117 (Pro117Ser): Comparison of clinical, neuropathological and cell culture phenotypes of Pro117Leu and Pro117Ser mutations
Autor: Jerzy Wegiel, Thomas Wisniewski, Izabela Kuchna, Wieslaw K. Dowjat
Publikováno v: Journal of Alzheimer's disease : JAD. 6(1)
A novel presenilin-1 (PS1) mutation (P117S) in an American pedigree is described. We compare clinical, neuropathological and cell culture phenotypes produced by this mutation with another codon 117 mutation that was earlier discovered by our group in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::487a20561615c3fef02dd6fb7bcdb63c
https://pubmed.ncbi.nlm.nih.gov/15004326
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5
Alzheimer's disease presenilin-1 expression modulates the assembly of neurofilaments
Autor: Thomas Wisniewski, Wieslaw K. Dowjat, H. M. Wisniewski
Publikováno v: Neuroscience. 103(1)
Mutations in presenilin-1 gene are responsible for the majority of early-onset familial Alzheimer’s disease cases. The function of this protein and the mechanism underlying the pathogenicity of its mutations are still unclear. To elucidate the role
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304dea722b1746e26ef4aa39d9ef8e4a
https://pubmed.ncbi.nlm.nih.gov/11311782
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6
Cell-type-specific enhancement of amyloid-beta deposition in a novel presenilin-1 mutation (P117L)
Autor: J Kulczycki, Eulalia Badmajew, Eirene Popovitch, Jerzy Wegiel, Wieslaw K. Dowjat, Henryk M. Wisniewski, I. Kuchna, Thomas Wisniewski, Michal Tarnawski
Publikováno v: Journal of neuropathology and experimental neurology. 57(9)
The presenilin-1 (PS1) gene mutation (Pro117Leu), recently identified in a Polish family is characterized by the earliest reported onset (from 24-31 years) of Alzheimer disease (AD) and a very short duration of disease (4-6 years). The neuropathology
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9fa8203de5758a1730423eac206f069
https://pubmed.ncbi.nlm.nih.gov/9737546
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7
A novel Polish presenilin-1 mutation (P117L) is associated with familial Alzheimer's disease and leads to death as early as the age of 28 years
Autor: Wanda Lojkowska, Thomas Wisniewski, J Kulczycki, Jerzy Wegiel, Olga Khorkova, B. Frangione, Joseph D. Buxbaum, H. M. Wisniewski, Spiros Efthimiopoulos, Wieslaw K. Dowjat
Publikováno v: Scopus-Elsevier
The majority of early-onset familial Alzheimer's disease (FAD) is associated with mutations in the presenilin-1 (PS1) gene. We describe a novel Polish PS1 mutation of Pro117Leu, associated with the earliest average age of onset and death so far repor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fcfa887e29164bfa0498ea6bd21869d
https://pubmed.ncbi.nlm.nih.gov/9507958
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10
Adhesion and locomotion of L5222 cells on endothelium, collagen and glass
Autor: Hanna M. Kowalczynska, Malgorzata Nowak, Jan Doroszewski, Wieslaw K. Dowjat
Publikováno v: Journal of cell science. 55
Examination was made of the adhesive interaction of L5222 leukaemia cells with endothelial cells, collagen and glass and of cell locomotion on endothelium and collagen. Leukaemia cells interacted with the substrate under stationary conditions. The fr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e760b92418f07897bf99289e8e30b49a
https://pubmed.ncbi.nlm.nih.gov/7107727
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