Mycobacterium bovis Wild-Type BCG or Recombinant BCG Secreting Murine IL-18 (rBCG/IL-18) Strains in Driving Immune Responses in Immunocompetent or Immunosuppressed Mice

Autor: Marek Fol, Marcin Włodarczyk, Magdalena Kowalewicz-Kulbat, Magdalena Druszczyńska, Krzysztof T. Krawczyk, Sebastian Wawrocki, Wiesława Rudnicka, Magdalena Chmiela

Publikováno v: Vaccines, Vol 10, Iss 4, p 615 (2022)

Mycobacterium tuberculosis infections remain a global health problem in immunosuppressed patients. The effectiveness of BCG (Bacillus Calmette–Guérin), an anti-tuberculosis vaccine, is unsatisfactory. Finding a new vaccine candidate is a priority.

Externí odkaz: https://doaj.org/article/178553232b664b539f9ec3729f49e7c7

Monocyte response receptors in BCG driven delayed type hypersensitivity to tuberculin.

Autor: Agnieszka Matusiak, Adriana Vrba, Magdalena Kowalewicz-Kulbat, Magdalena Druszczyńska, Karolina Kasztalska, Dominik Strapagiel, Magdalena Chmiela, Wiesława Rudnicka

Publikováno v: Folia Histochemica et Cytobiologica, Vol 46, Iss 3, Pp 353-359 (2008)

Tuberculosis (TB) still remains the leading cause of mortality due to bacterial pathogen. The only currently available vaccine against TB, Bacille Calmette-GuĂŠrin (BCG) is at best credited with a 50% overall protective efficacy. Skin testing with

Externí odkaz: https://doaj.org/article/bf893fe38e834075ab7e9a3441cef6e0

Dendritic Cell Activity Driven by Recombinant Mycobacterium bovis BCG Producing Human IL-18, in Healthy BCG Vaccinated Adults

Autor: Piotr Szpakowski, Franck Biet, Camille Locht, Małgorzata Paszkiewicz, Wiesława Rudnicka, Magdalena Druszczyńska, Fabrice Allain, Marek Fol, Joël Pestel, Magdalena Kowalewicz-Kulbat

Publikováno v: Journal of Immunology Research, Vol 2015 (2015)

Tuberculosis remains an enormous global burden, despite wide vaccination coverage with the Bacillus Calmette-Guérin (BCG), the only vaccine available against this disease, indicating that BCG-driven immunity is insufficient to protect the human popu

Externí odkaz: https://doaj.org/article/6b30fb8becee4beda854a648f0352d59

Lack of significant effect of interleukin-18 gene variants on tuberculosis susceptibility in the Polish population

Autor: Sebastian Wawrocki, Wiesława Rudnicka, Grzegorz Kielnierowski, Magdalena Druszczyńska

Publikováno v: Acta Biochimica Polonica.

Background: Polymorphisms in genes encoding cytokines are known to determine susceptibility to Mycobacterium tuberculosis (M.tb) infection. In particular, interleukin-18 (IL-18), an inducer of interferon-gamma (IFN-γ), playing an important role in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35499fa431a4cc656bdb51994f5a430e
https://doi.org/10.18388/abp.2019_2797

Decrease of IL-5 Production by Naive T Cells Cocultured with IL-18-Producing BCG-Pulsed Dendritic Cells from Patients Allergic to House Dust Mite

Autor: Piotr Szpakowski, Camille Locht, Wiesława Rudnicka, Franck Biet, Krzysztof Krawczyk, Marek L. Kowalski, Slawomir Kosinski, Magdalena Kowalewicz-Kulbat

Publikováno v: Vaccines
Vaccines, 2021, 9 (3), 14 p. ⟨10.3390/vaccines9030277⟩
Vaccines, MDPI, 2021, 9 (3), 14 p. ⟨10.3390/vaccines9030277⟩
Vaccines, Vol 9, Iss 277, p 277 (2021)
Volume 9
Issue 3

International audience; The only currently available anti-tuberculosis vaccine, Bacillus Calmette-Guérin (BCG), has been reported to also protect against unrelated diseases, including inflammatory diseases such as allergic asthma. Recombinant BCG st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83fb27a2f3ea577abadb219210283df7
https://doi.org/10.3390/vaccines9030277