Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Wiesław Szeja"'
Autor:
Magdalena Skonieczna, Kinga Plasa, Ewa Borowska, Agata Jakubowska, Wiesław Szeja, Anna Kasprzycka
Publikováno v:
Pharmaceuticals, Vol 17, Iss 9, p 1166 (2024)
The major environmental factor responsible for skin cancer is ultraviolet (UV) radiation, present in sunlight. UV radiation is directly linked to the production of reactive oxygen species (ROS), which accumulate in exposed cells and cause serious dam
Externí odkaz:
https://doaj.org/article/d568ce5ff23f4f449b38bd7bd4cf43c3
Autor:
Sebastian Makuch, Piotr Kupczyk, Marta Woźniak, Alicja Makarec, Maja Lipińska, Magdalena Klyta, Joanna Sulecka-Zadka, Wiesław Szeja, Mariachiara Gani, Valentina Rapozzi, Piotr Ziółkowski, Piotr Smoleński
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 838 (2024)
Psoriasis, a chronic immune-mediated skin disorder affecting over 125 million people globally, is characterized by abnormal keratinocyte proliferation and immune cell infiltration. Photodynamic therapy (PDT) remains underutilized in the treatment of
Externí odkaz:
https://doaj.org/article/1e5b5329abb246c39633b354cd609a8c
Autor:
Magdalena Staniszewska, Agnieszka Bronowicka-Szydełko, Kinga Gostomska-Pampuch, Jerzy Szkudlarek, Arkadiusz Bartyś, Tadeusz Bieg, Elżbieta Gamian, Agata Kochman, Bolesław Picur, Jadwiga Pietkiewicz, Piotr Kuropka, Wiesław Szeja, Jerzy Wiśniewski, Piotr Ziółkowski, Andrzej Gamian
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Non-enzymatic modification of proteins by carbohydrates, known as glycation, leads to generation of advanced glycation end-products (AGEs). In our study we used in vitro generated AGEs to model glycation in vivo. We discovered in vivo analog
Externí odkaz:
https://doaj.org/article/5e928347233642c5a6d161c60deb78d8
Autor:
Monika Domińska, Gabriela Pastuch-Gawołek, Magdalena Skonieczna, Wiesław Szeja, Adrian Domiński, Piotr Kurcok
Publikováno v:
Molecules, Vol 27, Iss 20, p 6918 (2022)
Based on the Warburg effect and the increased demand for glucose by tumor cells, a targeted drug delivery strategy was developed. A series of new glycoconjugates with increased ability to interact with GLUT transporters, responsible for the transport
Externí odkaz:
https://doaj.org/article/f0c488da87274433a6f87901a8f818c9
Autor:
Katarzyna Żurawska, Marcin Stokowy, Patryk Kapica, Monika Olesiejuk, Agnieszka Kudelko, Katarzyna Papaj, Magdalena Skonieczna, Wiesław Szeja, Krzysztof Walczak, Anna Kasprzycka
Publikováno v:
Molecules, Vol 26, Iss 23, p 7245 (2021)
The addition of 2-amino-1,3,4-thiadiazole derivatives with parallel iodination of differently protected glycals has been achieved using a double molar excess of molecular iodine under mild conditions. The corresponding thiadiazole derivatives of N-gl
Externí odkaz:
https://doaj.org/article/1a8e9745515a4c7aa3c1e6c560f4ccbc
Autor:
Marta Woźniak, Sebastian Makuch, Gabriela Pastuch-Gawołek, Jerzy Wiśniewski, Wiesław Szeja, Martyna Nowak, Monika Krawczyk, Siddarth Agrawal
Publikováno v:
Molecules, Vol 26, Iss 9, p 2547 (2021)
Patients with hematologic malignancies require intensive therapies, including high-dose chemotherapy. Antimetabolite–methotrexate (MTX) has been used for many years in the treatment of leukemia and in lymphoma patients. However, the lack of MTX spe
Externí odkaz:
https://doaj.org/article/f4a9a7dd8d574580b06a6580741f757a
Autor:
Marta Woźniak, Gabriela Pastuch-Gawołek, Sebastian Makuch, Jerzy Wiśniewski, Piotr Ziółkowski, Wiesław Szeja, Monika Krawczyk, Siddarth Agrawal
Publikováno v:
Pharmaceuticals, Vol 14, Iss 1, p 13 (2020)
The oxygen and nutrient-deprived tumor microenvironment is considered a key mechanism responsible for cancer resistance to chemotherapy. Methotrexate (MTX) is a widely incorporated chemotherapeutic agent employed in the treatment of several malignanc
Externí odkaz:
https://doaj.org/article/8fe84b39f91048bd92d496cae90d44ec
Publikováno v:
Molecules, Vol 19, Iss 11, Pp 18558-18573 (2014)
The need to find new EGFR inhibitors for use in combination with radiotherapy in the treatment of solid tumors has drawn our attention to compounds derived from genistein, a natural isoflavonoid. The antiproliferative potential of synthetic genistein
Externí odkaz:
https://doaj.org/article/683a05289a7d4fc8af81e479a8129083
Autor:
Ilona Wandzik, Wiesław Szeja, Urszula Nawrot, Tadeusz Bieg, Katarzyna Kral, Jadwiga Paszkowska
Publikováno v:
Molecules, Vol 18, Iss 7, Pp 8018-8027 (2013)
New derivatives of uridine which contain a b-ketoenol motif were synthesized, characterized and biologically tested. Synthesized compounds 1–4 showed no activity against bovine milk β-1,4-galactosyltransferase I at concentrations up to 2.0 mM and
Externí odkaz:
https://doaj.org/article/3eb8b60487e5430db9d388d5e49e86ec
Publikováno v:
Journal of Chemistry, Vol 2013 (2013)
This paper presents our attempt to investigate scopes and the limitations of olefin cross-metathesis (CM) reaction in the synthesis of complex C-glycosides of genistein and evaluation of their antiproliferative activities. Novel genistein glycoconjug
Externí odkaz:
https://doaj.org/article/dec71accff0c499a8ad44309a757c1a7