Hereditary Alpha Tryptasemia: Validation of a Single-Well Multiplex Digital Droplet PCR Assay in a Cohort of Symptomatic Patients.

Autor: Alheraky A; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Wierenga ATJ; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Simpelaar A; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Hesp LB; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Minovic I; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Bagheri N; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Roozendaal C; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Span LFR; Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Oude Elberink HNG; Department of Allergology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Kema IP; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Mulder AB; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Publikováno v: Clinical chemistry [Clin Chem] 2024 Feb 07; Vol. 70 (2), pp. 425-433.

Dietary methionine starvation impairs acute myeloid leukemia progression.

Autor: Cunningham A; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Erdem A; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Alshamleh I; Institut für Organische Chemie und Chemische Biologie, Zentrum für Biomolekulare Magnetische Resonanz, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany., Geugien M; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Pruis M; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Pereira-Martins DA; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Department of Internal Medicine, Medical School of Ribeirao Preto, University of São Paulo, Ribeirão Preto, Brazil., van den Heuvel FAJ; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Wierenga ATJ; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Ten Berge H; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Dennebos R; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., van den Boom V; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Hogeling SM; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Weinhäuser I; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Department of Internal Medicine, Medical School of Ribeirao Preto, University of São Paulo, Ribeirão Preto, Brazil., Knops R; Department of Laboratory Medicine, Radboud University Medical Center and Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands., de Blaauw P; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Heiner-Fokkema MR; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Woolthuis C; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Günther UL; Institute of Chemistry and Metabolomics, University of Lübeck, Lübeck, Germany., Rego EM; Department of Internal Medicine, Medical School of Ribeirao Preto, University of São Paulo, Ribeirão Preto, Brazil., Martens JHA; Department of Molecular Biology, RIMLS, Radboud University, Nijmegen, The Netherlands., Jansen JH; Department of Laboratory Medicine, Radboud University Medical Center and Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands., Schwalbe H; Institut für Organische Chemie und Chemische Biologie, Zentrum für Biomolekulare Magnetische Resonanz, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany., Huls G; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Schuringa JJ; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Publikováno v: Blood [Blood] 2022 Nov 10; Vol. 140 (19), pp. 2037-2052.

Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability.

Autor: Erdem A; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, Avda. Diagonal 643, Barcelona, 08028, Spain., Marin S; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, Avda. Diagonal 643, Barcelona, 08028, Spain.; CIBER of Hepatic and Digestive Diseases (CIBEREHD), Institute of Health Carlos III, 28029, Madrid, Spain.; Institute of Biomedicine of University of Barcelona, 08028, Barcelona, Spain., Pereira-Martins DA; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.; Hematology Division, LIM31, Faculdade de Medicina, University of São Paulo, São Paulo, SP, Brazil., Geugien M; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands., Cunningham A; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands., Pruis MG; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands., Weinhäuser I; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.; Hematology Division, LIM31, Faculdade de Medicina, University of São Paulo, São Paulo, SP, Brazil., Gerding A; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.; Laboratory of Pediatrics, Section Systems Medicine of Metabolism and Signaling, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Bakker BM; Laboratory of Pediatrics, Section Systems Medicine of Metabolism and Signaling, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Wierenga ATJ; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands., Rego EM; Hematology Division, LIM31, Faculdade de Medicina, University of São Paulo, São Paulo, SP, Brazil., Huls G; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands., Cascante M; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, Avda. Diagonal 643, Barcelona, 08028, Spain.; CIBER of Hepatic and Digestive Diseases (CIBEREHD), Institute of Health Carlos III, 28029, Madrid, Spain.; Institute of Biomedicine of University of Barcelona, 08028, Barcelona, Spain., Schuringa JJ; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands. j.j.schuringa@umcg.nl.

Publikováno v: Nature communications [Nat Commun] 2022 Apr 19; Vol. 13 (1), pp. 2013. Date of Electronic Publication: 2022 Apr 19.

HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells.

Autor: Wierenga ATJ; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, 9700RB The Netherlands.; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700RB Groningen, The Netherlands., Cunningham A; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, 9700RB The Netherlands., Erdem A; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, 9700RB The Netherlands., Lopera NV; 3Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Brouwers-Vos AZ; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, 9700RB The Netherlands., Pruis M; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, 9700RB The Netherlands., Mulder AB; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700RB Groningen, The Netherlands., Günther UL; 3Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Martens JHA; 4Department of Molecular Biology, Radboud Institute for Molecular Life Sciences (RIMLS), Nijmegen, The Netherlands., Vellenga E; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, 9700RB The Netherlands., Schuringa JJ; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, 9700RB The Netherlands.

Publikováno v: Cancer & metabolism [Cancer Metab] 2019 Dec 27; Vol. 7, pp. 11. Date of Electronic Publication: 2019 Dec 27 (Print Publication: 2019).

Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes.

Autor: Yi G; Department of Molecular Biology, Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands., Wierenga ATJ; Department of Hematology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, the Netherlands; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, the Netherlands., Petraglia F; Dipartimento di Biochimica, Biofisica e Patologia generale, Università degli Studi della Campania 'Luigi Vanvitelli,' Vico L. De Crecchio 7, 80138 Napoli, Italy., Narang P; Department of Molecular Biology, Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands., Janssen-Megens EM; Department of Molecular Biology, Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands., Mandoli A; Department of Molecular Biology, Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands., Merkel A; Centro Nacional de Análisis Genómico (CNAG), Parc Científic de Barcelona, Barcelona, Spain., Berentsen K; Department of Molecular Biology, Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands., Kim B; Department of Molecular Biology, Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands., Matarese F; Department of Molecular Biology, Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands., Singh AA; Department of Molecular Biology, Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands., Habibi E; Department of Molecular Biology, Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands., Prange KHM; Department of Molecular Biology, Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands., Mulder AB; Department of Hematology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, the Netherlands., Jansen JH; Department of Laboratory Medicine, Laboratory of Hematology, Radboud University, 6525 GA Nijmegen, the Netherlands., Clarke L; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK., Heath S; Centro Nacional de Análisis Genómico (CNAG), Parc Científic de Barcelona, Barcelona, Spain., van der Reijden BA; Department of Laboratory Medicine, Laboratory of Hematology, Radboud University, 6525 GA Nijmegen, the Netherlands., Flicek P; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK., Yaspo ML; Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany., Gut I; Centro Nacional de Análisis Genómico (CNAG), Parc Científic de Barcelona, Barcelona, Spain., Bock C; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, 1090 Vienna, Austria; Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria; Max Planck Institute for Informatics, Saarland Informatics Campus, 66123 Saarbrücken, Germany., Schuringa JJ; Department of Hematology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, the Netherlands., Altucci L; Dipartimento di Biochimica, Biofisica e Patologia generale, Università degli Studi della Campania 'Luigi Vanvitelli,' Vico L. De Crecchio 7, 80138 Napoli, Italy., Vellenga E; Department of Hematology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, the Netherlands., Stunnenberg HG; Department of Molecular Biology, Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands., Martens JHA; Department of Molecular Biology, Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands. Electronic address: j.martens@ncmls.ru.nl.

Publikováno v: Cell reports [Cell Rep] 2019 Jan 22; Vol. 26 (4), pp. 1059-1069.e6.