Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Wiep Scheper"'
Autor:
Lucia A. A. Giannini, Ruben G. Boers, Emma L. van derEnde, Jackie M. Poos, Lize C. Jiskoot, Joachim B. Boers, Wilfred F. J. vanIJcken, Elise G. Dopper, Yolande A. L. Pijnenburg, Harro Seelaar, Lieke H. Meeter, Jeroen G. J. vanRooij, Wiep Scheper, Joost Gribnau, John C. vanSwieten
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 3, Pp 744-756 (2024)
Abstract Objective Methylation of plasma cell‐free DNA (cfDNA) has potential as a marker of brain damage in neurodegenerative diseases such as frontotemporal dementia (FTD). Here, we study methylation of cfDNA in presymptomatic and symptomatic carr
Externí odkaz:
https://doaj.org/article/cc79cf26f61340c983c838b9a38da340
Autor:
Kevin Llewelyn Batenburg, Wiep Scheper
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 3, Pp 505-506 (2024)
Externí odkaz:
https://doaj.org/article/34f7927ca23a43be827cc5192d147101
Autor:
Santiago López-Begines, Ángela Lavado-Roldán, Cristina Mesa-Cruz, Fabiola Mavillard-Saborido, Nozha Borjini, Vera Wiersma, Carolina Aguado, Rafael Luján, José Luis Nieto-González, Wiep Scheper, Rafael Fernández-Chacón
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S442- (2023)
Externí odkaz:
https://doaj.org/article/62845157971246c9b668ba9d5fbf7b10
Autor:
Kevin L. Batenburg, Claudia Sestito, Paulien Cornelissen-Steijger, Jan R. T. van Weering, Leo S. Price, Vivi M. Heine, Wiep Scheper
Publikováno v:
Biological Procedures Online, Vol 25, Iss 1, Pp 1-14 (2023)
Abstract Background Intraneuronal tau aggregation is the major pathological hallmark of neurodegenerative tauopathies. It is now generally acknowledged that tau aggregation also affects astrocytes in a cell non-autonomous manner. However, mechanisms
Externí odkaz:
https://doaj.org/article/dc48a5e9b803420cb8bd12454e349851
Autor:
Anders Sandberg, Ernesto Berenjeno-Correa, Rosa Crespo Rodriguez, Michael Axenhus, Sophia Schedin Weiss, Kevin Batenburg, Jeroen J. M. Hoozemans, Lars O. Tjernberg, Wiep Scheper
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-20 (2022)
Abstract Background In Alzheimer’s disease (AD), amyloid-β 1–42 (Aβ42) neurotoxicity stems mostly from its soluble oligomeric aggregates. Studies of such aggregates have been hampered by the lack of oligomer-specific research tools and their in
Externí odkaz:
https://doaj.org/article/cee0908148f64f599e9891ba7768079f
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-21 (2022)
Abstract Background Granulovacuolar degeneration bodies (GVBs) are intracellular vesicular structures that commonly accompany pathological tau accumulations in neurons of patients with tauopathies. Recently, we developed the first model for GVBs in p
Externí odkaz:
https://doaj.org/article/fe261881414643b7a659164fcb0891a1
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10865 (2023)
Tau aggregation is central to the pathogenesis of a large group of neurodegenerative diseases termed tauopathies, but it is still unclear in which way neurons respond to tau pathology and how tau accumulation leads to neurodegeneration. A striking ne
Externí odkaz:
https://doaj.org/article/acbd69430e244370b783387fb6cb0115
Autor:
Emma M. Coomans, Deborah N. Schoonhoven, Hayel Tuncel, Sander C. J. Verfaillie, Emma E. Wolters, Ronald Boellaard, Rik Ossenkoppele, Anouk den Braber, Wiep Scheper, Patrick Schober, Steven P. Sweeney, J. Michael Ryan, Robert C. Schuit, Albert D. Windhorst, Frederik Barkhof, Philip Scheltens, Sandeep S. V. Golla, Arjan Hillebrand, Alida A. Gouw, Bart N. M. van Berckel
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-13 (2021)
Abstract Background The mechanism of synaptic loss in Alzheimer’s disease is poorly understood and may be associated with tau pathology. In this combined positron emission tomography (PET) and magnetoencephalography (MEG) study, we aimed to investi
Externí odkaz:
https://doaj.org/article/0311b602bb364b2b9a39d6b57ce39995
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-21 (2020)
Abstract In the brains of tauopathy patients, tau pathology coincides with the presence of granulovacuolar degeneration bodies (GVBs) both at the regional and cellular level. Recently, it was shown that intracellular tau pathology causes GVB formatio
Externí odkaz:
https://doaj.org/article/98975d3b7cab413292a419dc55c8f73c
Autor:
Judith M. van der Harg, Leslie Eggels, Fabian N. Bangel, Silvie R. Ruigrok, Rob Zwart, Jeroen J.M. Hoozemans, Susanne E. la Fleur, Wiep Scheper
Publikováno v:
Neurobiology of Disease, Vol 103, Iss , Pp 163-173 (2017)
Alzheimer's disease (AD) is a highly prevalent multifactorial disease for which Diabetes Mellitus (DM) is a risk factor. Abnormal phosphorylation and aggregation of tau is a key hallmark of AD. In animal models, DM induces or exacerbates the phosphor
Externí odkaz:
https://doaj.org/article/dd361cd919f04c81abebee5746c8e7ab