Mephenytoin as a marker for CYP2C19 enzyme activity: influence of analytical factors on teh outcome of phenotyping

Autor: Oosterhuis, B, Tamminga, W.J, Wemer, J, Wieling, J, Wilffert, B, Sakiman, E.P, de Leij, Lou, Jonkman, J.H.G., Boobis, A R, Kremers, P, Pelkonen, O, Pithan, K

Publikováno v: Proceedings European Symposium on the prediction of drug metabolism in man: progress and problems, 197-200
STARTPAGE=197;ENDPAGE=200;TITLE=Proceedings European Symposium on the prediction of drug metabolism in man: progress and problems

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::476e03097fd84d80694624bce5a838fd
https://research.rug.nl/en/publications/5182a178-7cce-4142-98fb-b2a7b31704a1

CHEMOMETRICS IN BIOANALYTICAL SAMPLE PREPARATION - A FRACTIONATED COMBINED MIXTURE AND FACTORIAL DESIGN FOR THE MODELING OF THE RECOVERY OF 5 TRICYCLIC AMINES FROM PLASMA AFTER LIQUID-LIQUID-EXTRACTION PRIOR TO HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

Autor: WIELING, J, MENSINK, CK, JONKMAN, JHG, COENEGRACHT, PMJ, DUINEVELD, CAA, DOORNBOS, DA

Publikováno v: Journal of Chromatography A, 629(2), 181-199. ELSEVIER SCIENCE BV

A general systematic approach is described for the chemometric modelling of liquid-liquid extraction data of drugs from biological fluids. Extraction solvents were selected from Snyder's solvent selectivity triangle: methyl tert.-butyl ether, methyle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::75230c903d984b4c85faa7385b5ed140
https://research.rug.nl/en/publications/907fc4bf-b238-49ac-bf61-0ba8422107ac

SELECTION OF ROBUST COMBINATIONS OF EXTRACTION LIQUID COMPOSITION AND INTERNAL STANDARD - MONTE-CARLO SIMULATION OF IMPROVEMENT OF ASSAY-METHODS WITH LIQUID-LIQUID-EXTRACTION PRIOR TO HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

Autor: WIELING, J, COENEGRACHT, PMJ, MENSINK, CK, JONKMAN, JHG, DOORNBOS, DA

Publikováno v: Journal of Chromatography A, 594(1-2), 45-64. ELSEVIER SCIENCE BV

The liquid-liquid extraction of a mixture of sulphonamides was achieved to examine the correlation between the experimental errors in the recoveries. Also, the impact of the composition of the extraction liquid was investigated. Six sulphonamides wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::893097d7496a51314e930370c907bcef
https://research.rug.nl/en/publications/cf736b7f-83cf-4784-9dd5-a3717b96cc34

DEVELOPMENT OF A LABORATORY ROBOTIC SYSTEM FOR AUTOMATED BIOANALYTICAL METHODS .1. THE DETERMINATION OF THEOPHYLLINE IN HUMAN PLASMA - A COMPARISON BETWEEN THE ROBOTIZED AND MANUAL METHOD

Autor: HEMPENIUS, J, WIELING, J, JONKMAN, JHG, DENOORD, OE, COENEGRACHT, PMJ, DOORNBOS, DA

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis, 8(4), 313-320. ELSEVIER SCIENCE BV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::7b887dbb11cbda8aafa3170846b624a3
https://research.rug.nl/en/publications/f5150a2f-9c9c-4e15-9306-bded51bf7f91

A Signal-Integrity Self-Test Concept for Debugging Nanometer CMOS ICs.

Autor: Petrescu, V., Pelgrom, M., Veendrick, H., Pavithran, P., Wieling, J.

Publikováno v: 2006 IEEE International Solid State Circuits Conference - Digest of Technical Papers; 2006, p2220-2229, 10p