Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Wieland Willker"'
Autor:
Dieter Leibfritz, Wolfram S. Kunz, Hans-Jochen Heinze, Heiko G. Niessen, Frank Angenstein, Wieland Willker, Liane Hilfert, Stefan Vielhaber, Kerstin Sander, Albert C. Ludolph, Grazyna Debska-Vielhaber
Publikováno v:
European Journal of Neuroscience. 25:1669-1677
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by a progressive loss of motor neurons. Visualizing corresponding metabolic changes in the brain of patients with ALS with proton magnetic resonance spectroscopy (
Publikováno v:
Novum Testamentum. 50:78-80
Autor:
Wieland Willker, Ulrich Flögel, Christiane Richter-Landsberg, Dieter Leibfritz, Annette Brand
Publikováno v:
Brain Research Protocols. 3:183-191
In vivo MRS studies on intact brain reflect the metabolism of all cells present, but do not distinguish between different cell types. NMR studies of immobilized cultured primary cells, such as neurons and astrocytes, are a useful model to monitor the
Autor:
Dieter Leibfritz, Wieland Willker
Publikováno v:
Magnetic Resonance in Chemistry. 36:S79-S84
Semi-selective 800 MHz 1H, 13C HSQC NMR spectra provide ultra-high resolution of the double bond region of lipid spectra and the possibility of assigning signals to individual unsaturated fatty acid side-chains such as 18:1, 18:2 or 20:4 even in comp
Publikováno v:
NMR in Biomedicine. 11:47-54
The polyamines putrescine, spermidine and spermine are involved in the regulation of various metabolic processes. It is therefore desirable to detect and quantify the polyamines with NMR. We present the proton and carbon assignments for all polyamine
Publikováno v:
NMR in Biomedicine. 10:50-58
13 C nuclear magnetic resonance spectroscopy was used to determine the absolute amounts of de novo synthesized amino acids in both the perchloric acid extracts and the hydrolyzed protein fractions of F98 glioma cells incubated for 2 h with 5 mmol/l [
Publikováno v:
Developmental Neuroscience. 18:449-459
13C-NMR spectroscopy of perchloric acid and lipid extracts of F98 glioma cells showed that volume-regulatory processes under anisosmotic conditions were accompanied by marked alterations in cellular metabolism. Production of alanine, glutamate, and g
Determination of heteronuclear long-range H,X coupling constants from gradient-selected HMBC spectra
Autor:
Dieter Leibfritz, Wieland Willker
Publikováno v:
Magnetic Resonance in Chemistry. 33:632-638
A gradient-selected J-HMBC experiment is presented. Coherence selection with magnetic field gradients results in HMBC spectra in which t1 noise is very low or completely eliminated. This makes it possible to detect unequivocally very small (
Autor:
Wieland Willker, Dieter Leibfritz
Publikováno v:
Magnetic Resonance in Chemistry. 32:665-669
Coherence pathway selection with gradients in carbon-detected experiments is demonstrated. Gradient selection (gs) offers excellent suppression of artifacts and unwanted magnetization, and in practice the signal-to-noise ratio is at least as good as
Publikováno v:
Journal of Magnetic Resonance, Series A. 107:94-98