Zobrazeno 1 - 10
of 1 825
pro vyhledávání: '"Wieland B"'
Autor:
Wieland B. Huttner
Publikováno v:
Frontiers in Molecular Medicine, Vol 4 (2024)
Externí odkaz:
https://doaj.org/article/bfd40a10c00f410596e6fb6f2caa7ba9
Role of cell metabolism in the pathophysiology of brain size-associated neurodevelopmental disorders
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106607- (2024)
Cell metabolism is a key regulator of human neocortex development and evolution. Several lines of evidence indicate that alterations in neural stem/progenitor cell (NPC) metabolism lead to abnormal brain development, particularly brain size-associate
Externí odkaz:
https://doaj.org/article/8be3c9af9d154509b399288606189a6a
Autor:
Lei Xing, Vasiliki Gkini, Anni I. Nieminen, Hui-Chao Zhou, Matilde Aquilino, Ronald Naumann, Katrin Reppe, Kohichi Tanaka, Peter Carmeliet, Oskari Heikinheimo, Svante Pääbo, Wieland B. Huttner, Takashi Namba
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Metabolism has recently emerged as a major target of genes implicated in the evolutionary expansion of human neocortex. One such gene is the human-specific gene ARHGAP11B. During human neocortex development, ARHGAP11B increases the abundance
Externí odkaz:
https://doaj.org/article/7f5a9fcd3d7146608de6b3e645883f2f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The development of the neocortex involves an interplay between neural cells and the vasculature. However, little is known about this interplay at the ultrastructural level. To gain a 3D insight into the ultrastructure of the developing neocortex, we
Externí odkaz:
https://doaj.org/article/92e2aa255f2c4d67b0c867f7789a9daa
Autor:
Michael Heide, Wieland B. Huttner
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
As is evident from the theme of the Research Topic “Small Size, Big Problem: Understanding the Molecular Orchestra of Brain Development from Microcephaly,” the pathomechanisms leading to mirocephaly in human are at best partially understood. As m
Externí odkaz:
https://doaj.org/article/a4cf26ef57b5413a98dfc44f1df59344
Autor:
Samir Vaid, Wieland B. Huttner
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
During development, the decision of stem and progenitor cells to switch from proliferation to differentiation is of critical importance for the overall size of an organ. Too early a switch will deplete the stem/progenitor cell pool, and too late a sw
Externí odkaz:
https://doaj.org/article/1afe231efb5f45b88a0eb86963103390
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
When considering what makes us human, the development of the neocortex, the seat of our higher cognitive abilities, is of central importance. Throughout this complex developmental process, neocortical stem and progenitor cells (NSPCs) exert a priming
Externí odkaz:
https://doaj.org/article/ce4d451193e049398481598c893c86a1
Autor:
Katherine R. Long, Wieland B. Huttner
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2022)
Extracellular matrix (ECM) has long been known to regulate many aspects of neural development in many different species. However, the role of the ECM in the development of the human neocortex is not yet fully understood. In this review we discuss the
Externí odkaz:
https://doaj.org/article/8c3d693f13304fab9bbfc2f3dc29c522
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
During mammalian brain development, neural stem and progenitor cells generate the neurons for the six-layered neocortex. The proliferative capacity of the different types of progenitor cells within the germinal zones of the developing neocortex is a
Externí odkaz:
https://doaj.org/article/cb7c4f1e7a464fa88559003e3171a580
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100494- (2021)
Summary: Interspecies chimerism is a useful tool to study interactions between cells of different genetic makeup in order to elucidate the mechanisms underlying non-cell-autonomous processes, including evolutionary events. However, generating intersp
Externí odkaz:
https://doaj.org/article/53a2604823ff48528d286c9ec3b083ff