Zobrazeno 1 - 10
of 360
pro vyhledávání: '"Wiek H Van Gilst"'
Autor:
Megan V Cannon, Herman HW Silljé, Jürgen WA Sijbesma, Inge Vreeswijk‐Baudoin, Jolita Ciapaite, Bart van der Sluis, Jan van Deursen, Gustavo JJ Silva, Leon J de Windt, Jan‐Åke Gustafsson, Pim van der Harst, Wiek H van Gilst, Rudolf A de Boer
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 9, Pp 1229-1243 (2015)
Abstract Pathological cardiac hypertrophy is characterized by a shift in metabolic substrate utilization from fatty acids to glucose, but the molecular events underlying the metabolic remodeling remain poorly understood. Here, we investigated the rol
Externí odkaz:
https://doaj.org/article/a60b17b5ab81414fab6747461a6c56fa
Autor:
Hasan Mahmud, Wellington Mardoqueu Candido, Linda van Genne, Inge Vreeswijk-Baudoin, Hongjuan Yu, Bart van de Sluis, Jan van Deursen, Wiek H van Gilst, Herman H W Silljé, Rudolf A de Boer
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89929 (2014)
The (pro)renin-renin receptor, (P)RR has been claimed to be a novel element of the renin-angiotensin system (RAS). The function of (P)RR has been widely studied in renal and vascular pathology but the cardio-specific function of (P)RR has not been st
Externí odkaz:
https://doaj.org/article/c4599e53a5514519b8058951b275fc41
Autor:
Jiang Gui, Jason H Moore, Scott M Williams, Peter Andrews, Hans L Hillege, Pim van der Harst, Gerjan Navis, Wiek H Van Gilst, Folkert W Asselbergs, Diane Gilbert-Diamond
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66545 (2013)
We present an extension of the two-class multifactor dimensionality reduction (MDR) algorithm that enables detection and characterization of epistatic SNP-SNP interactions in the context of a quantitative trait. The proposed Quantitative MDR (QMDR) m
Externí odkaz:
https://doaj.org/article/952894d1edee4bb98a933a3dad2f4665
Autor:
Hongjuan Yu, Wardit Tigchelaar, Debby P Y Koonen, Hemal H Patel, Rudolf A de Boer, Wiek H van Gilst, B Daan Westenbrink, Herman H W Silljé
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80815 (2013)
A kinase interacting protein 1 (AKIP1) is a molecular regulator of protein kinase A and nuclear factor kappa B signalling. Recent evidence suggests AKIP1 is increased in response to cardiac stress, modulates acute ischemic stress response, and is loc
Externí odkaz:
https://doaj.org/article/cfffa75d86364e4ab452dcc487d0ef62
Autor:
Anne Margreet De Jong, Isabelle C Van Gelder, Inge Vreeswijk-Baudoin, Megan V Cannon, Wiek H Van Gilst, Alexander H Maass
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72651 (2013)
BACKGROUND: Atrial fibrillation (AF) is often preceded by underlying cardiac diseases causing ventricular pressure overload. OBJECTIVE: It was our aim to investigate the progression of atrial remodeling in a small animal model of ventricular pressure
Externí odkaz:
https://doaj.org/article/3307e4af86264e86832e620ac700b4bd
Autor:
Rudolf A de Boer, Niek Verweij, Dirk J van Veldhuisen, Harm-Jan Westra, Stephan J L Bakker, Ron T Gansevoort, Anneke C Muller Kobold, Wiek H van Gilst, Lude Franke, Irene Mateo Leach, Pim van der Harst
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47385 (2012)
Galectin-3 is a lectin involved in fibrosis, inflammation and proliferation. Increased circulating levels of galectin-3 have been associated with various diseases, including cancer, immunological disorders, and cardiovascular disease. To enhance our
Externí odkaz:
https://doaj.org/article/3706cf1ece8f4b6eb42fd18493a0059b
Autor:
Yumei Wang, Sjoerd Landheer, Wiek H van Gilst, Aart van Amerongen, Hans-Peter Hammes, Robert H Henning, Leo E Deelman, Hendrik Buikema
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46781 (2012)
BACKGROUND: Dipeptidyl peptidase 4 (DPP4) and angiotensin-converting enzyme (ACE) are important target enzymes in glycemic control and renovascular protection. Here, we studied the effect of NWT-03, an egg protein hydrolysate with DPP4- and ACE-inhib
Externí odkaz:
https://doaj.org/article/e1fa8412c48e40ee98e7427ad06cebdd
Autor:
Liza S M Wong, Jardi Huzen, Rudolf A de Boer, Wiek H van Gilst, Dirk J van Veldhuisen, Pim van der Harst
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23118 (2011)
BACKGROUND: We aimed to find support for the hypothesis that telomere length (TL) is causally involved in the pathogenesis of ischemic heart failure (IHF). We measured TL in IHF patients and their high-risk offspring and determined whether mean leuko
Externí odkaz:
https://doaj.org/article/0213a9584e854ff0b16c1d138a83a11d
Autor:
John P Bentley, Folkert W Asselbergs, Christopher S Coffey, Patricia R Hebert, Jason H Moore, Hans L Hillege, Wiek H van Gilst
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12757 (2010)
Vascular fibrinolytic balance is maintained primarily by interplay of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1). Previous research has shown that polymorphisms in genes from the renin-angiotensin (RA), bra
Externí odkaz:
https://doaj.org/article/fcf4365163da480c897fc412ad04fcfa
Autor:
Bo Lu, Hasan Mahmud, Alexander H Maass, Bo Yu, Wiek H van Gilst, Rudolf A de Boer, Herman H W Silljé
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12963 (2010)
BI 2536 is a new anti-mitotic drug that targets polo-like kinase 1 (Plk1) and is currently under clinical development for cancer therapy. The effect of this drug on cancer cells has been extensively investigated, but information about the effects on
Externí odkaz:
https://doaj.org/article/3c0c946f75544c05a83e5ff78945240c