Výsledky vyhledávání - "Wiebke Wolfsgruber"

A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells

Autor: Sabine Brummer, Franz Hofmann, Oliver Kuppinger, Wiebke Wolfsgruber, Robert Feil, Susanne Feil

Publikováno v: Proceedings of the National Academy of Sciences. 100:13519-13524

Nitric oxide (NO) exerts both antiatherogenic and proatherogenic effects, but the cellular and molecular mechanisms that contribute to modulation of atherosclerosis by NO are not understood completely. The cGMP-dependent protein kinase I (cGKI) is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375f73ab323655ba32ed78681405c4f8
https://doi.org/10.1073/pnas.1936024100

Zobrazit plný text záznamu

Individual Cerebellar Purkinje Cells Express Different cGMP Phosphodiesterases (PDEs):In VivoPhosphorylation of cGMP-Specific PDE (PDE5) as an Indicator of cGMP-dependent protein kinase (PKG) Activation

Autor: Robert Feil, Wiebke Wolfsgruber, Sergei D. Rybalkin, Franz Hofmann, Joseph A. Beavo, Irina G. Rybalkina, Masami Shimizu-Albergine

Publikováno v: The Journal of Neuroscience. 23:6452-6459

The nitric oxide (NO)-cGMP pathway has been implicated as playing a crucial role in the induction of cerebellar long-term depression (LTD). The amplitude and duration of the cGMP signal is controlled by cyclic nucleotide phosphodiesterases (PDEs). He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9ef277487019c125fc13082e20ef6e
https://doi.org/10.1523/jneurosci.23-16-06452.2003

Zobrazit plný text záznamu

Hippocampal cGMP-Dependent Protein Kinase I Supports an Age- and Protein Synthesis-Dependent Component of Long-Term Potentiation But Is Not Essential for Spatial Reference and Contextual Memory

Autor: Carsten T. Wotjak, Franz Hofmann, Thomas Kleppisch, Robert Feil, Susanne Feil, Rüdiger Allmann, Wiebke Wolfsgruber, Sandra Goebbels, Klaus-Armin Nave

Publikováno v: ResearcherID

cGMP-dependent protein kinase I (cGKI) is expressed in the hippocampus, but its role in hippocampal long-term potentiation (LTP) is controversial. In addition, whether cGKI is involved in spatial learning has not been investigated. To address these i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588b0db8d558062ee0d31d7858d78921
https://doi.org/10.1523/jneurosci.23-14-06005.2003

Zobrazit plný text záznamu

Impairment of LTD and cerebellar learning by Purkinje cell–specific ablation of cGMP-dependent protein kinase I

Autor: Michael Meyer, Wiebke Wolfsgruber, Franz Hofmann, Susanne Feil, Jaroslaw J. Barski, Karl Schilling, Robert Feil, Chongde Luo, Jana Hartmann, Chris I. De Zeeuw, Arthur Konnerth

Publikováno v: The Journal of Cell Biology
Journal of Cell Biology, 163, 295-302. Rockefeller University Press

The molecular basis for cerebellar plasticity and motor learning remains controversial. Cerebellar Purkinje cells (PCs) contain a high concentration of cGMP-dependent protein kinase type I (cGKI). To investigate the function of cGKI in long-term depr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e390663fe3b51537d21b21e6a95fb477
http://europepmc.org/articles/PMC2173527

Zobrazit plný text záznamu

cGMP-Dependent Protein Kinase I Mediates the Negative Inotropic Effect of cGMP in the Murine Myocardium

Autor: Robert Feil, Jörg W. Wegener, Hermann Nawrath, Franz Hofmann, Susanne Kühbandner, Wiebke Wolfsgruber, Cláudia Werner

Publikováno v: Circulation Research. 90:18-20

To study the role of cGMP-dependent protein kinase I (cGKI) for cardiac contractility, force of contraction (F c ) was studied in electrically driven heart muscle from wild-type (WT) mice and from conventional and conditional cGKI knockout mice. Both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9583c218db80bcdec20c7f32aa3140c4
https://doi.org/10.1161/hh0102.103222

Zobrazit plný text záznamu