Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Wiebke Stahlschmidt"'
Autor:
Ngoc Chau, Phillip J. Robinson, Wiebke Stahlschmidt, Jennifer R. Baker, Adam McCluskey, Ainslie Whiting, Volker Haucke, Mark J. Robertson, Lisa von Kleist, Marc Nazaré, André Horatscheck, Samantha Sauer
Publikováno v:
Organic & Biomolecular Chemistry. 14:11266-11278
The development of a (Z)-5-((6,8-dichloro-4-oxo-4H-chromen-3-yl)methylene)-2-thioxothiazolidin-4-one (2), rhodanine-based lead that led to the Pitstop® 2 family of clathrin inhibitors is described herein. Head group substitution and bioisosteric rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d02a37f8164e3927b425d76a0f4e03
https://doi.org/10.1039/c6ob02308h
https://doi.org/10.1039/c6ob02308h
Autor:
Volker Haucke, Lisa von Kleist, Mark J. Robertson, Adam McCluskey, Wiebke Stahlschmidt, Phillip J. Robinson, Fiona M. Deane
Publikováno v:
Nature Protocols. 9:1592-1606
This protocol describes the synthesis of two classes of clathrin inhibitors, Pitstop 1 and Pitstop 2, along with two inactive analogs that can be used as negative controls (Pitstop inactive controls, Pitnot-2 and Pitnot-2-100). Pitstop-induced inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ce734a2f41f852aa3918f10fae20a6
https://doi.org/10.1038/nprot.2014.106
https://doi.org/10.1038/nprot.2014.106
Autor:
Mark J. Robertson, Wiebke Stahlschmidt, Kylie A. MacGregor, Phillip J. Robinson, Lisa von Kleist, Adam McCluskey, Ngoc Chau, Kelly A. Young, Ainslie Whiting, Volker Haucke
Publikováno v:
Journal of Medicinal Chemistry. 57:131-143
We reported the first small molecule inhibitors of the interaction between the clathrin N-terminal domain (TD) and endocyctic accessory proteins (i.e., clathrin inhibition1). Initial screening of a ∼17 000 small molecule ChemBioNet library identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb74178a5c8a0830d8e736f780bf365
https://doi.org/10.1021/jm4015263
https://doi.org/10.1021/jm4015263
Autor:
Michaela Blazíková, Wiebke Stahlschmidt, Widmar Tanner, Jan Malinsky, Vendula Stradalova, Guido Grossmann, Reinhard Rachel
Publikováno v:
Journal of Cell Science. 122:2887-2894
Plasma membrane of the yeast Saccharomyces cerevisiae contains stable lateral domains. We have investigated the ultrastructure of one type of domain, the membrane compartment of Can1 (MCC). In two yeast strains (nce102Δ and pil1Δ) that are defectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21a23b1ec671728ed85e913848d2c33
https://doi.org/10.1242/jcs.051227
https://doi.org/10.1242/jcs.051227
Publikováno v:
The journal of biological chemistry, 289: 4906-4918
Clathrin plays important roles in intracellular membrane traffic including endocytosis of plasma membrane proteins and receptors and protein sorting between the trans-Golgi network (TGN) and endosomes. Whether clathrin serves additional roles in rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1be3973d857273e747fb380c5a2098
https://europepmc.org/articles/PMC3931052/
https://europepmc.org/articles/PMC3931052/
Autor:
Miroslava Opekarová, Ina Weig-Meckl, Jan Malinsky, Wolf B. Frommer, Guido Grossmann, Wiebke Stahlschmidt, Martin Loibl, Widmar Tanner
Publikováno v:
The Journal of Cell Biology
In this study, we investigate whether the stable segregation of proteins and lipids within the yeast plasma membrane serves a particular biological function. We show that 21 proteins cluster within or associate with the ergosterol-rich membrane compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b955f9c877139421981cd76ebab45cc
https://pubmed.ncbi.nlm.nih.gov/19064668
https://pubmed.ncbi.nlm.nih.gov/19064668
Autor:
Kylie A. MacGregor, Jennette A. Sakoff, Wolfram Saenger, Ngoc Chau, Oleg Shupliakov, Mark J. Robertson, Arndt Pechstein, Adam McCluskey, Dmytro Puchkov, Volker Haucke, Haydar Bulut, Megan Chircop, Lisa von Kleist, Jens Peter von Kries, Hans-Georg Kräusslich, Kira Gromova, Phillip J. Robinson, Nikolay Tomilin, Wiebke Stahlschmidt
Publikováno v:
Cell. (3):471-484
SummaryClathrin-mediated endocytosis (CME) regulates many cell physiological processes such as the internalization of growth factors and receptors, entry of pathogens, and synaptic transmission. Within the endocytic network, clathrin functions as a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72f701595bb16f0785e1bb0d93e5c6b