Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Wiebke Maurer"'
Autor:
Gideon Syed Ali, Sabine Rebs, Hanna Eberl, Clarissa Zinke, Daniela Hübscher, Wiebke Maurer, Alexandra Busley, Lukas Cyganek, Katrin Streckfuss-Bömeke
Publikováno v:
Stem Cell Research, Vol 81, Iss , Pp 103538- (2024)
Takotsubo Syndrome (TTS) is a potentially life-threatening disease characterized by a transient left ventricular apical akinesia in response to β-adrenergic overstimulation. Since a genetic predisposition is assumed, we generated an iPSC-line carryi
Externí odkaz:
https://doaj.org/article/2d087a29afb247c79218229540a460cb
Autor:
Wiebke Maurer, Sabine Rebs, Steffen Köhne, Hanna Eberl, Bernd Wollnik, Arne Zibat, Katrin Streckfuss-Bömeke
Publikováno v:
Stem Cell Research, Vol 77, Iss , Pp 103409- (2024)
Filamin C (FLNC) is a highly important actin crosslinker and multi-adaptor protein in striated skeletal and cardiac muscle. Mutations have been linked to a range of cardiomyopathy types. Here, we generated induced pluripotent stem cells (iPSC) from a
Externí odkaz:
https://doaj.org/article/ef95fefded4444bb90e7254eefffb8eb
Autor:
Philipp Bengel, Nataliya Dybkova, Petros Tirilomis, Shakil Ahmad, Nico Hartmann, Belal A. Mohamed, Miriam Celine Krekeler, Wiebke Maurer, Steffen Pabel, Maximilian Trum, Julian Mustroph, Jan Gummert, Hendrik Milting, Stefan Wagner, Senka Ljubojevic-Holzer, Karl Toischer, Lars S. Maier, Gerd Hasenfuss, Katrin Streckfuss-Bömeke, Samuel Sossalla
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
In heart failure, increased CaMKII activity is decisively involved in arrhythmia formation. Here, the authors introduce the neuronal sodium channel NaV1.8 as a CaMKII downstream target as its specific knock-out reduces arrhythmias and improves surviv
Externí odkaz:
https://doaj.org/article/ba56cc69ae1140aebe506e2a3f9b30eb
Publikováno v:
Stem Cell Research, Vol 60, Iss , Pp 102677- (2022)
The sodium channel Nav1.8, encoded by SCN10A, is reported to contribute to arrhythmogenesis by inducing the late INa and thereby enhanced persistent Na+ current. However, its exact electrophysiological role in cardiomyocytes remains unclear. Here, we
Externí odkaz:
https://doaj.org/article/2f6e6bd20ac543fdbe19bcd47324ea67
Autor:
Daniela Hübscher, PhD, Sabine Rebs, MSc, Wiebke Maurer, MSc, Jelena R. Ghadri, MD, Ralf Dressel, MD, Christian Templin, MD, PhD, Katrin Streckfuss-Bömeke, PhD
Publikováno v:
Stem Cell Research, Vol 44, Iss , Pp - (2020)
The Takotsubo syndrome (TTS) is characterized by acute transient left ventricular dysfunction in the absence of obstructive coronary lesions. An enhanced β-adrenergic signaling and higher sensitivity to catecholamine-induced-toxicity were identified
Externí odkaz:
https://doaj.org/article/c063420ba0294971b327f2658c8125a6
Autor:
Markus Hoffmann, Svenja Victoria Kaufmann, Carina Fischer, Wiebke Maurer, Anna-Sophie Moldenhauer, Stefan Pöhlmann
Publikováno v:
Pathogens, Vol 8, Iss 4, p 192 (2019)
Ebola virus (EBOV) infection can cause severe and frequently fatal disease in human patients. The EBOV glycoprotein (GP) mediates viral entry into host cells. For this, GP depends on priming by the pH-dependent endolysosomal cysteine proteases cathep
Externí odkaz:
https://doaj.org/article/2aa2a71d46bc442795613a1b8509003b
Autor:
Streckfuss-Bömeke, Nico Hartmann, Maria Knierim, Wiebke Maurer, Nataliya Dybkova, Gerd Hasenfuß, Samuel Sossalla, Katrin
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 10189
In heart failure and atrial fibrillation, a persistent Na+ current (INaL) exerts detrimental effects on cellular electrophysiology and can induce arrhythmias. We have recently shown that NaV1.8 contributes to arrhythmogenesis by inducing a INaL. Geno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::7fa6488bfe22f683009489778f16d52f
Autor:
Wiebke, Maurer, Nico, Hartmann, Loukas, Argyriou, Samuel, Sossalla, Katrin, Streckfuss-Bömeke
Publikováno v:
Stem cell research. 60
The sodium channel Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::65a6dcd1ad1537053025ab5270b5507c
https://pubmed.ncbi.nlm.nih.gov/35092938
https://pubmed.ncbi.nlm.nih.gov/35092938
Autor:
Stefan Wagner, Wiebke Maurer, Hendrik Milting, Nico Hartmann, Katrin Streckfuss-Bömeke, Julian Mustroph, Belal A. Mohamed, Maximilian Trum, P Tirilomis, Lars S. Maier, Karl Toischer, Miriam Celine Krekeler, Jan Gummert, Senka Ljubojevic-Holzer, Steffen Pabel, Gerd Hasenfuss, Samuel Sossalla, Nataliya Dybkova, Shakil Ahmad, Philipp Bengel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
An interplay between Ca2+/calmodulin-dependent protein kinase IIδc (CaMKIIδc) and late Na+ current (INaL) is known to induce arrhythmias in the failing heart. Here, we elucidate the role of the sodium channel isoform NaV1.8 for CaMKIIδc-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a8415f93078d89d557c95a0d79a40d
Autor:
Anna Müllen, Heidi Hahn, Anke Frommhold, Dominik Simon Botermann, Anja Uhmann, Slavica Hristomanova Mitkovska, Sebastian Zabel, Nadine Brandes, Hanna Scheile, Ina Heß, Wiebke Maurer
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9295, p 9295 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 23
International Journal of Molecular Sciences
Volume 21
Issue 23
Basal cell carcinoma (BCC) originate from Hedgehog/Patched signaling-activated epidermal stem cells. However, the chemically induced tumorigenesis of mice with a CD4Cre-mediated biallelic loss of the Hedgehog signaling repressor Patched also induces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::825a8ec585826c5ec22abd42c4614b0e
https://www.mdpi.com/1422-0067/21/23/9295
https://www.mdpi.com/1422-0067/21/23/9295