Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Wiebke Kallenborn-Gerhardt"'
Publikováno v:
Antioxidants, Vol 11, Iss 6, p 1162 (2022)
Inflammation or injury to the somatosensory nervous system may result in chronic pain conditions, which affect millions of people and often cause major health problems. Emerging lines of evidence indicate that reactive oxygen species (ROS), such as s
Externí odkaz:
https://doaj.org/article/7b7a4b7df476416bbba49701aa3fdf8c
Autor:
Jasmine Kolb, Marie Anders-Maurer, Tanja Müller, Ann-Christin Hau, Britta Moyo Grebbin, Wiebke Kallenborn-Gerhardt, Christian Behrends, Dorothea Schulte
Publikováno v:
Stem Cell Reports, Vol 10, Iss 4, Pp 1184-1192 (2018)
Summary: Adult neurogenesis is regulated by stem cell niche-derived extrinsic factors and cell-intrinsic regulators, yet the mechanisms by which niche signals impinge on the activity of intrinsic neurogenic transcription factors remain poorly defined
Externí odkaz:
https://doaj.org/article/0345f968f6674b71a4db7a6f073899ae
Autor:
Tilman Gross, Gesine Wack, Katharina M. J. Syhr, Tanya Tolmachova, Miguel C. Seabra, Gerd Geisslinger, Ellen Niederberger, Achim Schmidtko, Wiebke Kallenborn-Gerhardt
Publikováno v:
Cells, Vol 9, Iss 6, p 1488 (2020)
Tissue injury and inflammation may result in chronic pain, a severe debilitating disease that is associated with great impairment of quality of life. An increasing body of evidence indicates that members of the Rab family of small GTPases contribute
Externí odkaz:
https://doaj.org/article/126b9a9a996b4adabf0cf92813466115
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29240 (2011)
Accumulating evidence indicates that increased generation of reactive oxygen species (ROS) contributes to the development of exaggerated pain hypersensitivity during persistent pain. In the present study, we investigated the antinociceptive efficacy
Externí odkaz:
https://doaj.org/article/0fb8ff869b86484ba9a634abbf6b6a0b
Autor:
Katrin Schröder, Miriam S. Kuth, Katharina Metzner, Wiebke Kallenborn-Gerhardt, Anne R. Bresnick, Achim Schmidtko, Ilka Wittig, Gesine Wack, Elena Wang, Ralf P. Brandes
Publikováno v:
Free Radical Biology and Medicine. 168:155-167
Previous studies suggested that reactive oxygen species (ROS) produced by NADPH oxidase 4 (Nox4) affect the processing of neuropathic pain. However, mechanisms underlying Nox4-dependent pain signaling are incompletely understood. In this study, we ai
Autor:
Achim Schmidtko, Lea Kennel, Oliver Drees, Doris Koesling, Wiebke Kallenborn-Gerhardt, Jonas Petersen, Catherine Isabell Real, Rebecca Dorothee Steubing, Andreas Friebe, Evanthia Mergia, Ruirui Lu
Publikováno v:
Pain. 160:607-618
A large body of evidence indicates that nitric oxide (NO)/cGMP signaling essentially contributes to the processing of chronic pain. In general, NO-induced cGMP formation is catalyzed by 2 isoforms of guanylyl cyclase, NO-sensitive guanylyl cyclase 1
Publikováno v:
Neuroscience letters. 721
Signaling mediated by soluble epoxide hydrolase (sEH) has been reported to play an important role in pain processing. Previous studies revealed that sEH activity is inhibited by specific binding of electrophiles to a redox-sensitive thiol (Cys521) ad
Autor:
Ruirui Lu, Jonas Petersen, Wiebke Kallenborn-Gerhardt, Cathrin Flauaus, Robert Lukowski, Peter Ruth, Achim Schmidtko, Lea Kennel, Oliver Drees
Publikováno v:
Neuropharmacology. 125:386-395
Intermediate conductance calcium-activated potassium channels (KCa3.1) have been recently implicated in pain processing. However, the functional role and localization of KCa3.1 in the nociceptive system are largely unknown. We here characterized the
Autor:
Katharina Metzner, Jonas Petersen, Miriam S. Kuth, Stephan W. Hohmann, Lea Kennel, Domenico Del Turco, Oliver Drees, Sandra Heine, Ruirui Lu, Tilman Gross, Gesine Wack, Achim Schmidtko, Gerd Geisslinger, Stylianos Michalakis, Mandy H. Paul, Wiebke Kallenborn-Gerhardt, Elvir Becirovic, Cathrin Flauaus, Martin Biel, Dina Nemirovski
Publikováno v:
Neuropharmacology. 171:108087
Cyclic nucleotide-gated (CNG) channels, which are directly activated by cAMP and cGMP, have long been known to play a key role in retinal and olfactory signal transduction. Emerging evidence indicates that CNG channels are also involved in signaling
Autor:
Mirco Steger, Lea Kennel, Gerd Geisslinger, Ruirui Lu, Reynir Scheving, Irmgard Tegeder, Wiebke Kallenborn-Gerhardt, Aimee L. Edinger, Jonas Petersen, Jana E. Lorenz, Juliana Heidler, Christine V. Möser, Achim Schmidtko, Heinrich Heide, Cathrin Flauaus, Ilka Wittig
Publikováno v:
Pain. 158(7)
Chronic pain is accompanied by production of reactive oxygen species (ROS) in various cells that are important for nociceptive processing. Recent data indicate that ROS can trigger specific redox-dependent signaling processes, but the molecular targe