Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Wiebke Baars"'
Autor:
Claudia Pokoyski, Wiebke Baars, Mark Windheim, Thomas F. Reubold, Jasmin Zischke, Antje Brinkmann, Penelope C. Kay-Fedorov, Reinhard Schwinzer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Transgenic expression of protective molecules in porcine cells and tissues is a promising approach to prevent xenograft rejection. Viruses have developed various strategies to escape the host’s immune system. We generated porcine B cells (
Externí odkaz:
https://doaj.org/article/12793a81b1ea49b0b6bc28041c5cf640
Autor:
Andrea Bähr, Tobias Käser, Elisabeth Kemter, Wilhelm Gerner, Mayuko Kurome, Wiebke Baars, Nadja Herbach, Kirsti Witter, Annegret Wünsch, Stephanie C Talker, Barbara Kessler, Hiroshi Nagashima, Armin Saalmüller, Reinhard Schwinzer, Eckhard Wolf, Nikolai Klymiuk
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155676 (2016)
We have successfully established and characterized a genetically modified pig line with ubiquitous expression of LEA29Y, a human CTLA4-Ig derivate. LEA29Y binds human B7.1/CD80 and B7.2/CD86 with high affinity and is thus a potent inhibitor of T cell
Externí odkaz:
https://doaj.org/article/e75f73ab30a64d0e96c7cf098e868895
Autor:
Rabea Hein, Hendrik Sake, Antje Brinkmann, Constanca Figueiredo, Andrea Lucas-Hahn, Reinhard Schwinzer, Wiebke Baars, Hans‐Joachim Schuberth, Heiner Niemann, Claudia Pokoyski, Björn Petersen, Monika Nowak-Imialek, Joachim Hundrieser
Publikováno v:
American Journal of Transplantation. 20:988-998
Porcine xenografts lacking swine leukocyte antigen (SLA) class I are thought to be protected from human T cell responses. We have previously shown that SLA class I deficiency can be achieved in pigs by CRISPR/Cas9-mediated deletion of β2 -microglobu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::238905482b645eb798af2e61876f4129
https://doi.org/10.1111/ajt.15710
https://doi.org/10.1111/ajt.15710
Autor:
Rabea, Hein, Hendrik J, Sake, Claudia, Pokoyski, Joachim, Hundrieser, Antje, Brinkmann, Wiebke, Baars, Monika, Nowak-Imialek, Andrea, Lucas-Hahn, Constanca, Figueiredo, Hans-Joachim, Schuberth, Heiner, Niemann, Björn, Petersen, Reinhard, Schwinzer
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsREFERENCES. 20(4)
Porcine xenografts lacking swine leukocyte antigen (SLA) class I are thought to be protected from human T cell responses. We have previously shown that SLA class I deficiency can be achieved in pigs by CRISPR/Cas9-mediated deletion of β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c167be4761ae8f24561b0cde4122384d
https://pubmed.ncbi.nlm.nih.gov/31733031
https://pubmed.ncbi.nlm.nih.gov/31733031
Autor:
Reinhard Schwinzer, Rabea Hein, Andrea Lucas-Hahn, Heinke Eylers, Antje Brinkmann, Doris Hermann, Heiner Niemann, Wiebke Baars, Petra Hassel, Antje Frenzel, Klaus-Gerd Hadeler, Björn Petersen, Hendrik Sake, Monika Nowak-Imialek, Roswitha Becker
Publikováno v:
Xenotransplantation. 26
Background Despite major improvements in pig‐to‐primate xenotransplantation, long‐term survival of xenografts is still challenging. The major histocompatibility complex (MHC) class I, which is crucial in cellular immune response, is an importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc6b53e122cfa01c81d2dad59a1a54a
https://doi.org/10.1111/xen.12525
https://doi.org/10.1111/xen.12525
Autor:
Dorothee Römermann, Reinhard Schwinzer, Jürgen Klempnauer, Anna Buermann, Joachim Hundrieser, Wiebke Baars
Publikováno v:
Xenotransplantation. 23:347-356
Background The development of donor-reactive antibodies is regarded to be an important barrier limiting long-term outcome of allo- and xenografts. We asked whether enhanced signaling via the co-inhibitory receptor programmed cell death-1 (PD-1; CD279
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c843e251b751c6baa0a0dee3b08aadf
https://doi.org/10.1111/xen.12261
https://doi.org/10.1111/xen.12261
Autor:
Dennis Rataj, Andrea Lucas-Hahn, Ulrich Baulain, Sonja Werwitzke, Anjan K. Bongoni, Heiner Niemann, Hellen Ahrens, Robert Rieben, Joachim Denner, Reinhard Schwinzer, Doris Herrmann, Petra Hassel, Wiebke Baars, Alain Despont, Wilfried A. Kues, Andreas Tiede, Maren Ziegler, P. S. Garimella, Bjoern Petersen
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation an
Acute vascular rejection (AVR), in particular microvascular thrombosis, is an important barrier to successful pig-to-primate xenotransplantation. Here, we report the generation of pigs with decreased tissue factor (TF) levels induced by small interfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdaacd4c955bff9f936e95c2c3931cc4
Autor:
Anna Buermann, Reinhard Schwinzer, Rabea Hein, Stoyan G. Petkov, Wiebke Baars, Antje Brinkmann, Heiner Niemann, Andrea Lucas-Hahn, Björn Petersen
Publikováno v:
Xenotransplantation. 25(5)
Background The programmed cell death-1 (PD-1, CD279)/PD-Ligand1 (PD-L1, CD274) receptor system is crucial for controlling the balance between immune activation and induction of tolerance via generation of inhibitory signals. Expression of PD-L1 is as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640f53ea1f12e73f8503ce79ef02ed82
https://pubmed.ncbi.nlm.nih.gov/29446180
https://pubmed.ncbi.nlm.nih.gov/29446180
Autor:
Sonja Haertle, Reinhard Schwinzer, Andreas Blutke, A. Wuensch, Claudius Faber, Nikolai Klymiuk, Mayuko Kurome, Hiroshi Nagashima, Jan-Michael Abicht, Bruno Reichart, Andrea Baehr, Ruediger Wanke, Wiebke Baars, Robert Rieben, David Ayares, Barbara Kessler, Elisabeth Kemter, Valeri Zakhartchenko, Eckhard Wolf, Anjan K. Bongoni
Publikováno v:
TRANSPLANTATION
Wuensch, Annegret; Baehr, Andrea; Bongoni, Anjan; Kemter, Elisabeth; Blutke, Andreas; Baars, Wiebke; Haertle, Sonja; Zakhartchenko, Valeri; Kurome, Mayuko; Kessler, Barbara; Faber, Claudius; Abicht, Jan-Michael; Reichart, Bruno; Wanke, Ruediger; Schwinzer, Reinhard; Nagashima, Hiroshi; Rieben, Robert; Ayares, David; Wolf, Eckhard and Klymiuk, Nikolai (2014). Regulatory sequences of the porcine THBD gene facilitate endothelial-specific expression of bioactive human thrombomodulin in single-and multitransgenic pigs. Transplantation, 97(2), pp. 138-147. Lippincott Williams & Wilkins 10.1097/TP.0b013e3182a95cbc
Wuensch, Annegret; Baehr, Andrea; Bongoni, Anjan; Kemter, Elisabeth; Blutke, Andreas; Baars, Wiebke; Haertle, Sonja; Zakhartchenko, Valeri; Kurome, Mayuko; Kessler, Barbara; Faber, Claudius; Abicht, Jan-Michael; Reichart, Bruno; Wanke, Ruediger; Schwinzer, Reinhard; Nagashima, Hiroshi; Rieben, Robert; Ayares, David; Wolf, Eckhard and Klymiuk, Nikolai (2014). Regulatory sequences of the porcine THBD gene facilitate endothelial-specific expression of bioactive human thrombomodulin in single-and multitransgenic pigs. Transplantation, 97(2), pp. 138-147. Lippincott Williams & Wilkins 10.1097/TP.0b013e3182a95cbc
Background. Among other mismatches between human and pig incompatibilities in the blood coagulation systems hamper the xenotransplantation of vascularized organs. The provision of the porcine endothelium with human thrombomodulin (hTM) is hypothesize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::072a37368c95729cd703bb7d13b51e03
Autor:
Valeri Zakhartchenko, Tatiana Flisikowska, Eckhard Wolf, Marek Switonski, Reinhard Schwinzer, Beate Rieblinger, Alexander Kind, Krzysztof Flisikowski, Joachim Denner, Konrad Fischer, Simone Kraner-Scheiber, Izabela Szczerbal, Wiebke Baars, Mayuko Kurome, Anna Buermann, Susanne Christan, Elena Plotzki, Heiner Niemann, Barbara Kessler, Angelika Schnieke, Marlene Edlinger, Björn Petersen
Publikováno v:
Scientific Reports
Xenotransplantation from pigs could alleviate the shortage of human tissues and organs for transplantation. Means have been identified to overcome hyperacute rejection and acute vascular rejection mechanisms mounted by the recipient. The challenge is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3634b68c6a5a91cd43135bf73883ca