Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Wiebke, Nissen"'
Autor:
Martin M. Jendryka, Uwe Lewin, Bastiaan van der Veen, Sampath K. T. Kapanaiah, Vivien Prex, Daniel Strahnen, Thomas Akam, Birgit Liss, Anton Pekcec, Wiebke Nissen, Dennis Kätzel
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract The anterior cingulate cortex (ACC) has been implicated in attention deficit hyperactivity disorder (ADHD). More specifically, an appropriate balance of excitatory and inhibitory activity in the ACC may be critical for the control of impulsi
Externí odkaz:
https://doaj.org/article/e03ece03855f4b4da4d865aaec55d90b
Autor:
Bastiaan van der Veen, Sampath K. T. Kapanaiah, Kasyoka Kilonzo, Peter Steele-Perkins, Martin M. Jendryka, Stefanie Schulz, Bosiljka Tasic, Zizhen Yao, Hongkui Zeng, Thomas Akam, Janet R. Nicholson, Birgit Liss, Wiebke Nissen, Anton Pekcec, Dennis Kätzel
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
In order to identify receptors that may serve as therapeutic targets in the treatment of impulse control disorders, van der Veen et al developed a systematic target discovery approach combining behavioural chemogenetics and gene expression analysis.
Externí odkaz:
https://doaj.org/article/cd48bdbae6944aca8dc5ad44ab6da068
Autor:
Dennis Kätzel, Wiebke Nissen, Anton Pekcec, Daniel Ursu, Martin M. Jendryka, Bastiaan van der Veen, Birgit Liss, Monika Palchaudhuri
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Muscarinic Designer Receptors Exclusively Activated by Designer Drugs (DREADD) gated by clozapine-N-oxide (CNO) allow selective G-protein cascade activation in genetically specified cell-types in vivo. Here we compare the pharmacokinetics, off-target
Autor:
Bastiaan, van der Veen, Sampath K T, Kapanaiah, Kasyoka, Kilonzo, Peter, Steele-Perkins, Martin M, Jendryka, Stefanie, Schulz, Bosiljka, Tasic, Zizhen, Yao, Hongkui, Zeng, Thomas, Akam, Janet R, Nicholson, Birgit, Liss, Wiebke, Nissen, Anton, Pekcec, Dennis, Kätzel
Publikováno v:
Communications Biology
Pathological impulsivity is a debilitating symptom of multiple psychiatric diseases with few effective treatment options. To identify druggable receptors with anti-impulsive action we developed a systematic target discovery approach combining behavio
Publikováno v:
Neuropharmacology. 178
While neuropsychiatric drugs influence neural activity across multiple brain regions, the current understanding of their mechanism of action derives from studies that investigate an influence of a given drug onto a pre-selected and small number of br
Publikováno v:
Schizophr Bull
Accumulating evidence supports parvalbumin expressing inhibitory interneuron (PV IN) dysfunction in the prefrontal cortex as a cause for cognitive impairment associated with schizophrenia (CIAS). PV IN decreased activity is suggested to be the culpri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::337f51d678817fa7272e2fd8b8704180
https://europepmc.org/articles/PMC7342098/
https://europepmc.org/articles/PMC7342098/
BACKGROUND: Patients with schizophrenia show deficits in neural network function which can be measured by specific EEG signals such as basal gamma oscillations and 40 Hz auditory steady-state response (ASSR)[1]. Parvalbumin-positive (PV) interneurons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffae4020768e3f2bfede00a620a0290
https://europepmc.org/articles/PMC6455246/
https://europepmc.org/articles/PMC6455246/
Autor:
Melinda Paizs, Karri Lamsa, Wiebke Nissen, Kathryn Newton, Paul Harrison, Ole Paulsen, Dimitrios Kotzadimitriou
Publikováno v:
eNeuro
Hypofunction ofN-methyl-d-aspartate receptors (NMDARs) in inhibitory GABAergic interneurons is implicated in the pathophysiology of schizophrenia (SZ), a heritable disorder with many susceptibility genes. However, it is still unclear how SZ risk gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55117ce8d1aac59c89a461b7b52c87a6
Publikováno v:
Biological Psychiatry. 85:S275
Publikováno v:
Oren, I, Nissen, W, Kullmann, D M, Somogyi, P & Lamsa, K P 2009, ' Role of ionotropic glutamate receptors in long-term potentiation in rat hippocampal CA1 oriens-lacunosum moleculare interneurons ', Journal of Neuroscience, vol. 29, no. 4, pp. 939-950 . https://doi.org/10.1523/JNEUROSCI.3251-08.2009
Some interneurons of the hippocampus exhibit NMDA receptor-independent long-term potentiation (LTP) that is induced by presynaptic glutamate release when the postsynaptic membrane potential is hyperpolarized. This “anti-Hebbian” form of LTP is pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49602a6c9397229fb704a89718b324a
https://doi.org/10.1523/jneurosci.3251-08.2009
https://doi.org/10.1523/jneurosci.3251-08.2009