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Thrombotic risk determined by rare and common SERPINA1 variants in a population‐based cohort study

Autor: Manderstedt, Eric, Halldén, Christer, Lind‐Halldén, Christina, Elf, Johan, Svensson, Peter J., Engström, Gunnar, Melander, Olle, Baras, Aris ^*, Lotta, Luca A. ^*, Zöller, Bengt ^*, Abecasis, Goncalo, Cantor, Michael, Coppola, Giovanni, Economides, Aris, Overton, John D., Reid, Jeffrey G., Shuldiner, Alan, Beechert, Christina, Forsythe, Caitlin, Fuller, Erin D., Gu, Zhenhua, Lattari, Michael, Lopez, Alexander, Manoochehri, Kia, Padilla, Maria Sotiropoulos, Pradhan, Manasi, Schleicher, Thomas D., Ulloa, Ricardo H., Widom, Louis, Wolf, Sarah E., Bai, Xiaodong, Balasubramanian, Suganthi, Blumenfeld, Andrew, Boutkov, Boris, Eom, Gisu, Habegger, Lukas, Hawes, Alicia, Khalid, Shareef, Krasheninina, Olga, Lanche, Rouel, Mansfield, Adam J., Maxwell, Evan K., Nafde, Mrunali, O’Keeffe, Sean, Orelus, Max, Panea, Razvan, Polanco, Tommy, Rasool, Ayesha, Salerno, William, Staples, Jeffrey C., Jones, Marcus B., Mighty, Jason, Mitnaul, Lyndon J.

Publikováno v: In Journal of Thrombosis and Haemostasis June 2022 20(6):1421-1427

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Autor: Shah, Sonia, Henry, Albert, Roselli, Carolina, Lin, Honghuang, Sveinbjornsson, Gardar, Fatemifar, Ghazaleh, Hedman, Asa K, Wilk, Jemma B, Morley, Michael P, Chaffin, Mark D, Helgadottir, Anna, Verweij, Niek, Dehghan, Abbas, Almgren, Peter, Andersson, Charlotte, Aragam, Krishna G, Arnlov, Johan, Backman, Joshua D, Biggs, Mary L, Bloom, Heather L, Brandimarto, Jeffrey, Brown, Michael R, Buckbinder, Leonard, Carey, David J, Chasman, Daniel I, Chen, Xing, Chen, Xu, Chung, Jonathan, Chutkow, William, Cook, James P, Delgado, Graciela E, Denaxas, Spiros, Doney, Alexander S, Doerr, Marcus, Dudley, Samuel C, Dunn, Michael E, Engstrom, Gunnar, Esko, Tonu, Felix, Stephan B, Finan, Chris, Ford, Ian, Ghanbari, Mohsen, Ghasemi, Sahar, Giedraitis, Vilmantas, Giulianini, Franco, Gottdiener, John S, Gross, Stefan, Gudbjartsson, Daniel F, Gutmann, Rebecca, Haggerty, Christopher M, van der Harst, Pim, Hyde, Craig L, Ingelsson, Erik, Jukema, J Wouter, Kavousi, Maryam, Khaw, Kay-Tee, Kleber, Marcus E, Kober, Lars, Koekemoer, Andrea, Langenberg, Claudia, Lind, Lars, Lindgren, Cecilia M, London, Barry, Lotta, Luca A, Lovering, Ruth C, Luan, Jian'an, Magnusson, Patrik, Mahajan, Anubha, Margulies, Kenneth B, Maerz, Winfried, Melander, Olle, Mordi, Ify R, Morgan, Thomas, Morris, Andrew D, Morris, Andrew P, Morrison, Alanna C, Nagle, Michael W, Nelson, Christopher P, Niessner, Alexander, Niiranen, Teemu, O'Donoghue, Michelle L, Owens, Anjali T, Palmer, Colin NA, Parry, Helen M, Perola, Markus, Portilla-Fernandez, Eliana, Psaty, Bruce M, Rice, Kenneth M, Ridker, Paul M, Romaine, Simon PR, Rotter, Jerome I, Salo, Perttu, Salomaa, Veikko, van Setten, Jessica, Shalaby, Alaa A, Smelser, Diane T, Smith, Nicholas L, Stender, Steen, Stott, David J, Svensson, Per, Tammesoo, Mari-Liis, Taylor, Kent D, Teder-Laving, Maris, Teumer, Alexander, Thorgeirsson, Gudmundur, Thorsteinsdottir, Unnur, Torp-Pedersen, Christian, Trompet, Stella, Tyl, Benoit, Uitterlinden, Andre G, Veluchamy, Abirami, Voelker, Uwe, Voors, Adriaan A, Wang, Xiaosong, Wareham, Nicholas J, Waterworth, Dawn, Weeke, Peter E, Weiss, Raul, Wiggins, Kerri L, Xing, Heming, Yerges-Armstrong, Laura M, Yu, Bing, Zannad, Faiez, Zhao, Jing Hua, Hemingway, Harry, Samani, Nilesh J, McMurray, John JV, Yang, Jian, Visscher, Peter M, Newton-Cheh, Christopher, Malarstig, Anders, Holm, Hilma, Lubitz, Steven A, Sattar, Naveed, Holmes, Michael V, Cappola, Thomas P, Asselbergs, Folkert W, Hingorani, Aroon D, Kuchenbaecker, Karoline, Ellinor, Patrick T, Lang, Chim C, Stefansson, Kari, Smith, J Gustav, Vasan, Ramachandran S, Swerdlow, Daniel I, Lumbers, R Thomas, Abecasis, Goncalo, Backman, Joshua, Bai, Xiaodong, Balasubramanian, Suganthi, Banerjee, Nilanjana, Baras, Aris, Barnard, Leland, Beechert, Christina, Blumenfeld, Andrew, Cantor, Michael, Chai, Yating, Coppola, Giovanni, Damask, Amy, Dewey, Frederick, Economides, Aris, Eom, Gisu, Forsythe, Caitlin, Fuller, Erin D, Gu, Zhenhua, Gurski, Lauren, Guzzardo, Paloma M, Habegger, Lukas, Hahn, Young, Hawes, Alicia, van Hout, Cristopher, Jones, Marcus B, Khalid, Shareef, Lattari, Michael, Li, Alexander, Lin, Nan, Liu, Daren, Lopez, Alexander, Manoochehri, Kia, Marchini, Jonathan, Marcketta, Anthony, Maxwell, Evan K, McCarthy, Shane, Mitnaul, Lyndon J, O'Dushlaine, Colm, Overton, John D, Padilla, Maria Sotiropoulos, Paulding, Charles, Penn, John, Pradhan, Manasi, Reid, Jeffrey G, Schleicher, Thomas D, Schurmann, Claudia, Shuldiner, Alan, Staples, Jeffrey C, Sun, Dylan, Toledo, Karina, Ulloa, Ricardo H, Widom, Louis, Wolf, Sarah E, Yadav, Ashish, Ye, Bin, Ctr, Regeneron Genetics

Publikováno v: Nature Communications, 11(1). NATURE PUBLISHING GROUP
Nature Communications
Nature Communications, 11(1):163. Nature Publishing Group
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Shah, S, Henry, A, Roselli, C, Lin, H, Sveinbjörnsson, G, Fatemifar, G, Hedman, Å K, Wilk, J B, Morley, M P, Chaffin, M D, Helgadottir, A, Verweij, N, Dehghan, A, Almgren, P, Andersson, C, Aragam, K G, Ärnlöv, J, Backman, J D, Biggs, M L, Bloom, H L, Brandimarto, J, Brown, M R, Buckbinder, L, Carey, D J, Chasman, D I, Chen, X, Chen, X, Chung, J, Chutkow, W, Cook, J P, Delgado, G E, Denaxas, S, Doney, A S, Dörr, M, Dudley, S C, Dunn, M E, Engström, G, Esko, T, Felix, S B, Finan, C, Ford, I, Ghanbari, M, Ghasemi, S, Giedraitis, V, Giulianini, F, Gottdiener, J S, Gross, S, Guðbjartsson, D F, Gutmann, R, Haggerty, C M, van der Harst, P, Hyde, C L, Ingelsson, E, Jukema, J W, Kavousi, M, Khaw, K-T, Kleber, M E, Køber, L, Koekemoer, A, Langenberg, C, Lind, L, Lindgren, C M, London, B, Lotta, L A, Lovering, R C, Luan, J, Magnusson, P, Mahajan, A, Margulies, K B, März, W, Melander, O, Mordi, I R, Morgan, T, Morris, A D, Morris, A P, Morrison, A C, Nagle, M W, Nelson, C P, Niessner, A, Niiranen, T, O’Donoghue, M L, Owens, A T, Palmer, C N A, Parry, H M, Perola, M, Portilla-Fernandez, E, Psaty, B M, Abecasis, G, Backman, J, Bai, X, Balasubramanian, S, Banerjee, N, Baras, A, Barnard, L, Beechert, C, Blumenfeld, A, Cantor, M, Chai, Y, Coppola, G, Damask, A, Dewey, F, Economides, A, Eom, G, Forsythe, C, Fuller, E D, Gu, Z, Gurski, L, Guzzardo, P M, Habegger, L, Hahn, Y, Hawes, A, van Hout, C, Jones, M B, Khalid, S, Lattari, M, Li, A, Lin, N, Liu, D, Lopez, A, Manoochehri, K, Marchini, J, Marcketta, A, Maxwell, E K, McCarthy, S, Mitnaul, L J, O’Dushlaine, C, Overton, J D, Padilla, M S, Paulding, C, Penn, J, Pradhan, M, Reid, J G, Schleicher, T D, Schurmann, C, Shuldiner, A, Staples, J C, Sun, D, Toledo, K, Ulloa, R H, Widom, L, Wolf, S E, Yadav, A, Ye, B, Rice, K M, Ridker, P M, Romaine, S P R, Rotter, J I, Salo, P, Salomaa, V, van Setten, J, Shalaby, A A, Smelser, D T, Smith, N L, Stender, S, Stott, D J, Svensson, P, Tammesoo, M-L, Taylor, K D, Teder-Laving, M, Teumer, A, Thorgeirsson, G, Thorsteinsdottir, U, Torp-Pedersen, C, Trompet, S, Tyl, B, Uitterlinden, A G, Veluchamy, A, Völker, U, Voors, A A, Wang, X, Wareham, N J, Waterworth, D, Weeke, P E, Weiss, R, Wiggins, K L, Xing, H, Yerges-Armstrong, L M, Yu, B, Zannad, F, Zhao, J H, Hemingway, H, Samani, N J, McMurray, J J V, Yang, J, Visscher, P M, Newton-Cheh, C, Malarstig, A, Holm, H, Lubitz, S A, Sattar, N, Holmes, M V, Cappola, T P, Asselbergs, F W, Hingorani, A D, Kuchenbaecker, K, Ellinor, P T, Lang, C C, Stefansson, K, Smith, J G, Vasan, R S, Swerdlow, D I & Lumbers, R T 2020, ' Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure ', Nature Communications, vol. 11, no. 1, 163 . https://doi.org/10.1038/s41467-019-13690-5
2020, ' Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure ', Nature Communications, vol. 11, no. 1, pp. 163 . https://doi.org/10.1038/s41467-019-13690-5
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.163. ⟨10.1038/s41467-019-13690-5⟩
Shah, S, Henry, A, Roselli, C, Lin, H, Sveinbjörnsson, G, Fatemifar, G, Hedman, Å K, Wilk, J B, Morley, M P, Chaffin, M D, Helgadottir, A, Verweij, N, Dehghan, A, Almgren, P, Andersson, C, Aragam, K G, Ärnlöv, J, Backman, J D, Biggs, M L, Bloom, H L, Brandimarto, J, Brown, M R, Buckbinder, L, Carey, D J, Chasman, D I, Chen, X, Chen, X, Chung, J, Chutkow, W, Cook, J P, Delgado, G E, Denaxas, S, Doney, A S, Dörr, M, Dudley, S C, Dunn, M E, Engström, G, Esko, T, Felix, S B, Finan, C, Ford, I, Ghanbari, M, Ghasemi, S, Morris, A P, Morris, A D, Nelson, C P, Smith, N L, Zhao, J H, Yang, J & Holmes, M V 2020, ' Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure ', Nature Communications, vol. 11, no. 1, pp. 163 . https://doi.org/10.1038/s41467-019-13690-5
Shah, S, Henry, A, Roselli, C, Lin, H, Sveinbjörnsson, G, Fatemifar, G, Hedman, Å K, Wilk, J B, Morley, M P, Chaffin, M D, Helgadottir, A, Verweij, N, Dehghan, A, Almgren, P, Andersson, C, Aragam, K G, Ärnlöv, J, Backman, J D, Biggs, M L, Bloom, H L, Brandimarto, J, Brown, M R, Buckbinder, L, Carey, D J, Chasman, D I, Chen, X, Chen, X, Chung, J, Chutkow, W, Cook, J P, Delgado, G E, Denaxas, S, Doney, A S, Dörr, M, Dudley, S C, Dunn, M E, Engström, G, Esko, T, Felix, S B, Finan, C, Ford, I, Ghanbari, M, Ghasemi, S, Giedraitis, V, Giulianini, F, Køber, L, Regeneron Genetics Center, Stender, S, Torp-Pedersen, C, Weeke, P E, Vasan, R S, Swerdlow, D I & Lumbers, R T 2020, ' Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure ', Nature Communications, vol. 11, 163 . https://doi.org/10.1038/s41467-019-13690-5

Publisher's version (útgefin grein)
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a894b6e7f703eee196676f48718af1b7
https://doi.org/10.1038/s41467-019-13690-5