Propagation of prions causing synucleinopathies in cultured cells

Autor: Woerman, Amanda L., Stöhr, Jan, Aoyagi, Atsushi, Rampersaud, Ryan, Krejciova, Zuzana, Watts, Joel C., Ohyama, Takao, Patel, Smita, Widjaja, Kartika, Oehler, Abby, Sanders, David W., Diamond, Marc I., Seeley, William W., Middleton, Lefkos T., Gentleman, Steve M., Mordes, Daniel A., Südhof, Thomas C., Giles, Kurt, Prusiner, Stanley B.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2015 Sep 01. 112(35), E4949-E4958.

Externí odkaz: https://www.jstor.org/stable/26464146

Antiprion compounds that reduce PrPSc levels in dividing and stationary-phase cells

Autor: Silber, B. Michael, Gever, Joel R., Li, Zhe, Gallardo-Godoy, Alejandra, Renslo, Adam R., Widjaja, Kartika, Irwin, John J., Rao, Satish, Jacobson, Matthew P., Ghaemmaghami, Sina, Prusiner, Stanley B.

Publikováno v: In Bioorganic & Medicinal Chemistry 15 December 2013 21(24):7999-8012

An integrated strategy for the discovery of drug targets by the analysis of protein–protein interactions

Autor: Peltier, John M. ^*, Askovic, Srdjan, Becklin, Robert R., Chepanoske, Cindy Lou, Ho, Yew-Seng J., Kery, Vladimir, Lai, Shuping, Mujtaba, Tahmina, Pyne, Mike, Robbins, Paul B., Rechenberg, Moritz von, Richardson, Bonnie, Savage, Justin, Sheffield, Peter, Thompson, Sam, Weir, Lawrence, Widjaja, Kartika, Xu, Nafei, Zhen, Yuejun, Boniface, J. Jay

Publikováno v: In International Journal of Mass Spectrometry 2004 238(2):119-130

Familial Parkinson's point mutation abolishes multiple system atrophy prion replication

Autor: Woerman, Amanda L, Kazmi, Sabeen A, Patel, Smita, Aoyagi, Atsushi, Oehler, Abby, Widjaja, Kartika, Mordes, Daniel A, Olson, Steven H, Prusiner, Stanley B

Publikováno v: Woerman, AL; Kazmi, SA; Patel, S; Aoyagi, A; Oehler, A; Widjaja, K; et al.(2018). Familial Parkinson's point mutation abolishes multiple system atrophy prion replication. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115(2), 409-414. doi: 10.1073/pnas.1719369115. UCSF: Retrieved from: http://www.escholarship.org/uc/item/5z27d83d
Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 2

In the neurodegenerative disease multiple system atrophy (MSA), α-synuclein misfolds into a self-templating conformation to become a prion. To compare the biological activity of α-synuclein prions in MSA and Parkinson's disease (PD), we developed n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b566d8c9779776f6f38798e5f55c19c3
http://www.escholarship.org/uc/item/5z27d83d

Optimization of Arylamides as Novel, Potent and Brain-penetrant Antiprion Lead Compounds

Autor: Li, Zhe, Rao, Satish, Gever, Joel R, Widjaja, Kartika, Prusiner, Stanley B, Silber, B Michael

Publikováno v: ACS medicinal chemistry letters, vol 4, iss 7

The prion diseases caused by PrPSc, an alternatively folded form of the cellular prion protein (PrPC), are rapidly progressive, fatal, and untreatable neurodegenerative syndromes. We employed HTS ELISA assays to identify compounds that lower the leve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::8c30fb819b5cde30b2995841d4ee525b
https://escholarship.org/uc/item/85p0892q