Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Wided Najahi‐Missaoui"'
Publikováno v:
Life, Vol 14, Iss 6, p 672 (2024)
In drug development, it is not uncommon that an active substance exhibits efficacy in vitro but lacks the ability to specifically reach its target in vivo. As a result, targeted drug delivery has become a primary focus in the pharmaceutical sciences.
Externí odkaz:
https://doaj.org/article/97e99827be454e29914fea248e5dae81
Autor:
Wided Najahi‐Missaoui, Nhat D. Quach, Amber Jenkins, Isha Dabke, Payaningal R. Somanath, Brian S. Cummings
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 5, Pp n/a-n/a (2019)
Abstract P21‐activated kinase‐1 (PAK‐1) is a serine/threonine kinase involved in multiple signaling pathways that mediate cellular functions such as cytoskeletal motility, cell proliferation, and survival. PAK‐1 expression is altered in vario
Externí odkaz:
https://doaj.org/article/642da310aeee4bd2836650ee4416f5a8
Publikováno v:
International Journal of Molecular Sciences. 24:6615
Since their first discovery in the 1960s by Alec Bangham, liposomes have been shown to be effective drug delivery systems for treating various cancers. Several liposome-based formulations received approval by the U.S. Food and Drug Administration (FD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0891ce2b14482b776525de3d35640093
https://doi.org/10.3390/ijms24076615
https://doi.org/10.3390/ijms24076615
Insight into the Function of Active Site Residues in the Catalytic Mechanism of Human Ferrochelatase
Autor:
Harry A. Dailey, Wided Najahi-Missaoui, Mesafint T. Shiferaw, Amy E. Medlock, Angela N. Albetel, William N. Lanzilotta
Publikováno v:
Biochem J
Ferrochelatase catalyzes the insertion of ferrous iron into a porphyrin macrocycle to produce the essential cofactor, heme. In humans this enzyme not only catalyzes the terminal step, but also serves a regulatory step in the heme synthesis pathway. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132eb0c55547d6c359416bfc51548459
https://europepmc.org/articles/PMC9138182/
https://europepmc.org/articles/PMC9138182/
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9396, p 9396 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 24
International Journal of Molecular Sciences
Volume 21
Issue 24
P21 activated kinases (or group I PAKs) are serine/threonine kinases whose expression is altered in prostate and breast cancers. PAK-1 activity is inhibited by the small molecule &ldquo
Inhibitor targeting PAK-1 activation-3&rdquo
(IPA-3),
Inhibitor targeting PAK-1 activation-3&rdquo
(IPA-3),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848b1ebb9e961382cc15dcda9bff62f1
https://www.mdpi.com/1422-0067/21/24/9396
https://www.mdpi.com/1422-0067/21/24/9396
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 385, p 385 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 385, p 385 (2021)
The field of nanotechnology has grown over the last two decades and made the transition from the benchtop to applied technologies. Nanoscale-sized particles, or nanoparticles, have emerged as promising tools with broad applications in drug delivery,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401fb187355de2dc69fe6e9e7e0bb6c0
https://pubmed.ncbi.nlm.nih.gov/33396561
https://pubmed.ncbi.nlm.nih.gov/33396561
Sterically stabilized liposomes targeting P21 (RAC1) activated kinase-1 and secreted phospholipase A
Publikováno v:
Oncology Letters
Metastatic prostate cancer (PCa) has a very high mortality rate in men, in Western countries and lacks reliable treatment. The advanced-stage PCa cells overexpress P21 (RAC1) activated kinase-1 (PAK1) and secreted phospholipase A2 (sPLA2) suggesting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::122b1449c0ff6c39f3d58520d2a107c8
https://pubmed.ncbi.nlm.nih.gov/32934746
https://pubmed.ncbi.nlm.nih.gov/32934746
Autor:
Tamara A. Dailey, Harry A. Dailey, Amy E. Medlock, Chia Kuei Wu, John Rose, Wided Najahi-Missaoui, Amy E. Burden, Peter S. Horanyi
Publikováno v:
Biochemistry. 46:7973-7979
Ferrochelatase catalyzes the terminal step in heme biosynthesis, the insertion of ferrous iron into protoporphyrin to form protoheme IX. The crystal structures of human ferrochelatase both with and without the protoporphyrin substrate bound have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58b10bdf7db714570e780ef28bd4e45
https://doi.org/10.1021/bi700151f
https://doi.org/10.1021/bi700151f
Autor:
William N. Lanzilotta, Teresa A. Ross, Joseph S. Burch, Tamara A. Dailey, Wided Najahi-Missaoui, Harry A. Dailey, Jessica R. O’Brien, Amy E. Medlock
Ferrochelatase catalyzes the formation of protoheme from two potentially cytotoxic products, iron and protoporphyrin IX. While much is known from structural and kinetic studies on human ferrochelatase of the dynamic nature of the enzyme during cataly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a6682818e21b2b3001ef926604b125
https://europepmc.org/articles/PMC3448031/
https://europepmc.org/articles/PMC3448031/
Autor:
Wided Najahi-Missaoui, Harry A. Dailey
Mutations resulting in diminished activity of the dimeric enzyme ferrochelatase are a prerequisite for the inherited disorder erythropoietic protoporphyria (EPP). Patients with clinical EPP have only 10% to 30% of normal levels of ferrochelatase acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76cf606407abed6ff8e2b983d2caf281
https://europepmc.org/articles/PMC1473221/
https://europepmc.org/articles/PMC1473221/