Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Widdrington, JD"'
Autor:
Widdrington, JD, Gomez-Duran, A, Steyn, JS, Pyle, A, Ruchaud-Sparagano, M-H, Scott, J, Baudouin, SV, Rostron, AJ, Simpson, J, Chinnery FMedSci, PF
Monocytes from sepsis patients have mitochondrial DNA (mtDNA) depletion and immune deactivation. Here we find that THP-1 cell immune responses are impaired by experimentally depleting mtDNA, through dysregulated immune signalling, and rescued by inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03274b52a3e6bafd1b4e916d8eae7f5b
Autor:
Widdrington, JD, Ashfaq, I, Puvaneswaran, B, Ong, EL, Schwab, U, Price, DA, schmid, ML, Pandit, R
Publikováno v:
Journal of the Royal College of Physicians of Edinburgh; March 2017, Vol. 47 Issue: 2 p1-6, 6p
Autor:
Widdrington JD; Department of Infection and Tropical Medicine, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK. j.widdrington@nhs.net.; Centre for Clinical Infection, James Cook University Hospital, Marton Road, Middlesbrough, TS4 3BW, UK. j.widdrington@nhs.net., Bond H; Department of Infection and Tropical Medicine, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK.; Centre for Clinical Infection, James Cook University Hospital, Marton Road, Middlesbrough, TS4 3BW, UK., Schwab U; Department of Infection and Tropical Medicine, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK., Price DA; Department of Infection and Tropical Medicine, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK., Schmid ML; Department of Infection and Tropical Medicine, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK., McCarron B; Centre for Clinical Infection, James Cook University Hospital, Marton Road, Middlesbrough, TS4 3BW, UK., Chadwick DR; Centre for Clinical Infection, James Cook University Hospital, Marton Road, Middlesbrough, TS4 3BW, UK., Narayanan M; Department of Microbiology, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK., Williams J; Centre for Clinical Infection, James Cook University Hospital, Marton Road, Middlesbrough, TS4 3BW, UK., Ong E; Department of Infection and Tropical Medicine, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK.
Publikováno v:
Infection [Infection] 2018 Dec; Vol. 46 (6), pp. 785-792. Date of Electronic Publication: 2018 Jul 27.
Autor:
Widdrington JD; Department of Infection and Tropical Medicine, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK. j.widdrington@nhs.net., Emmerson I; Department of Infection and Tropical Medicine, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK. I.Emmerson@nhs.net.; Clinical Research Department, South Tyneside Hospital, Harton Lane, South Tyneside NE34 0PL, UK. I.Emmerson@nhs.net., Cullinan M; Department of Infection and Tropical Medicine, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK. milo.cullinan@nuth.nhs.uk., Narayanan M; Department of Microbiology, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK. manjusha.narayanan@nuth.nhs.uk., Klejnow E; Department of Infection and Tropical Medicine, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK. eleanor.klejnow@nhs.net., Watson A; Department of Infection and Tropical Medicine, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK. ao_watson@hotmail.co.uk., Ong ELC; Department of Infection and Tropical Medicine, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK. edmund.ong@nuth.nhs.uk., Schmid ML; Department of Infection and Tropical Medicine, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK. matthias.schmid@nuth.nhs.uk., Price DA; Department of Infection and Tropical Medicine, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK. david.price@nuth.nhs.uk., Schwab U; Department of Infection and Tropical Medicine, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK. uli.schwab@nuth.nhs.uk., Duncan CJA; Department of Infection and Tropical Medicine, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK. christopher.duncan@newcastle.ac.uk.; Institute of Cellular Medicine, Inflammation, Immunology and Immunotherapy Theme, Room M3.119, William Leech Building, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK. christopher.duncan@newcastle.ac.uk.
Publikováno v:
Medical sciences (Basel, Switzerland) [Med Sci (Basel)] 2018 Oct 30; Vol. 6 (4). Date of Electronic Publication: 2018 Oct 30.
Autor:
Pinder EM; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK., Rostron AJ; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK., Hellyer TP; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK., Ruchaud-Sparagano MH; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK., Scott J; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK., Macfarlane JG; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK., Wiscombe S; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK., Widdrington JD; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK., Roy AI; Integrated Critical Care Unit, Sunderland Royal Hospital, Sunderland, UK., Linnett VC; Intensive Care Unit, Queen Elizabeth Hospital, Gateshead, UK., Baudouin SV; Intensive Care Unit, Royal Victoria Infirmary, Newcastle upon Tyne, UK., Wright SE; Intensive Care Unit, Freeman Hospital, Newcastle upon Tyne, UK., Chadwick T; Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK., Fouweather T; Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK., Juss JK; Department of Medicine, University of Cambridge, Cambridge, UK., Chilvers ER; Department of Medicine, University of Cambridge, Cambridge, UK., Bowett SA; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Parker J; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., McAuley DF; Centre for Experimental Medicine, Queen's University Belfast, Belfast, UK., Conway Morris A; Division of Anaesthesia, University of Cambridge, Cambridge, UK., Simpson AJ; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
Publikováno v:
Thorax [Thorax] 2018 Oct; Vol. 73 (10), pp. 918-925. Date of Electronic Publication: 2018 Jul 31.
Autor:
Widdrington JD; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Gomez-Duran A; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.; MRC Mitochondrial Biology Unit, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom., Pyle A; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Ruchaud-Sparagano MH; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Scott J; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Baudouin SV; Department of Anaesthesia, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom., Rostron AJ; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Lovat PE; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Chinnery PF; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.; MRC Mitochondrial Biology Unit, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom., Simpson AJ; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
Publikováno v:
Frontiers in immunology [Front Immunol] 2018 Sep 27; Vol. 9, pp. 2217. Date of Electronic Publication: 2018 Sep 27 (Print Publication: 2018).
Autor:
Widdrington JD; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Gomez-Duran A; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Medical Research Council Mitochondrial Biology Unit, Cambridge Biomedical Campus, Cambridge, United Kingdom., Steyn JS; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Bioinformatics Support Unit, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom., Pyle A; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Ruchaud-Sparagano MH; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Scott J; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Baudouin SV; Department of Anaesthesia, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom., Rostron AJ; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Simpson J; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address: j.simpson@ncl.ac.uk., Chinnery PF; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Medical Research Council Mitochondrial Biology Unit, Cambridge Biomedical Campus, Cambridge, United Kingdom; Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom. Electronic address: pfc25@cam.ac.uk.
Publikováno v:
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2017 Nov; Vol. 140 (5), pp. 1461-1464.e8. Date of Electronic Publication: 2017 Jun 17.
Autor:
Scott J; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Harris GJ; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Pinder EM; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Macfarlane JG; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Hellyer TP; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Rostron AJ; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Conway Morris A; Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom., Thickett DR; Centre for Translational Inflammation Research, University of Birmingham, Queen Elizabeth Hospital, Birmingham, United Kingdom., Perkins GD; Warwick Medical School Clinical Trials Unit and Heart of England Foundation Trust, University of Warwick, Coventry, United Kingdom., McAuley DF; Centre for Infection and Immunity, Health Sciences Building, Queen's University Belfast, Belfast, United Kingdom; Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, United Kingdom., Widdrington JD; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Wiscombe S; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Baudouin SV; Department of Anaesthetics, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom., Roy AI; Integrated Critical Care Unit, Sunderland Royal Hospital, Sunderland, United Kingdom., Linnett VC; Intensive Care Unit, Queen Elizabeth Hospital, Gateshead, United Kingdom., Wright SE; Intensive Care Unit, Freeman Hospital, Newcastle upon Tyne, United Kingdom., Ruchaud-Sparagano MH; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Simpson AJ; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address: j.simpson@ncl.ac.uk.
Publikováno v:
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2016 Feb; Vol. 137 (2), pp. 535-44. Date of Electronic Publication: 2015 Sep 18.
Autor:
Hellyer TP; Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, UK., Morris AC; MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK Department of Anaesthesia, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., McAuley DF; Centre for Infection and Immunity, Health Sciences Building, Queen's University Belfast, Belfast, UK Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK., Walsh TS; MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK., Anderson NH; Centre for Population Health Sciences, University of Edinburgh, Medical School, Edinburgh, UK., Singh S; Intensive Care Unit, Chelsea and Westminster Hospital, Imperial College London, London, UK., Dark P; Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Sciences Centre & Intensive Care Unit, Salford Royal NHS Foundation Trust, Greater Manchester, UK., Roy AI; Integrated Critical Care Unit, Sunderland Royal Hospital, Sunderland, UK., Baudouin SV; Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, UK Intensive Care Unit, Royal Victoria Infirmary, Newcastle upon Tyne, UK., Wright SE; Intensive Care Unit, Freeman Hospital, Newcastle upon Tyne, UK., Perkins GD; University of Warwick and Heart of England NHS Foundation Trust, Coventry, UK., Kefala K; Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK., Jeffels M; Newcastle Clinical Trials Unit, William Leech Building, Medical School, Newcastle University, Newcastle upon Tyne, UK., McMullan R; Department of Medical Microbiology, Kelvin Building, The Royal Hospitals, Belfast, UK., O'Kane CM; Centre for Infection and Immunity, Health Sciences Building, Queen's University Belfast, Belfast, UK., Spencer C; Intensive Care Unit, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK., Laha S; Intensive Care Unit, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK., Robin N; Intensive Care Unit, Countess of Chester NHS Trust, Chester, UK., Gossain S; Public Health Laboratory, Heart of England NHS Foundation Trust, Birmingham, UK., Gould K; Public Health England & Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, UK., Ruchaud-Sparagano MH; Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, UK., Scott J; Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, UK., Browne EM; Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, UK., MacFarlane JG; Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, UK., Wiscombe S; Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, UK., Widdrington JD; Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, UK., Dimmick I; Bioscience Centre (West Wing), International Centre for Life, Newcastle University, Newcastle upon Tyne, UK., Laurenson IF; Department of Clinical Microbiology, Royal Infirmary of Edinburgh, Edinburgh, UK., Nauwelaers F; Becton Dickinson Biosciences, Erembodegem (Aalst), Belgium., Simpson AJ; Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, UK.
Publikováno v:
Thorax [Thorax] 2015 Jan; Vol. 70 (1), pp. 41-7. Date of Electronic Publication: 2014 Oct 08.
Autor:
Widdrington JD; Department of Medicine, Royal Victoria Infirmary, Newcastle-Upon-Tyne, UK. john_widd@hotmail.com, Echevarria C, Bone M, Ellis R
Publikováno v:
BMJ case reports [BMJ Case Rep] 2010 Sep 07; Vol. 2010. Date of Electronic Publication: 2010 Sep 07.