Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.

Autor: Warrington NM; University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia., Beaumont RN; Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK., Horikoshi M; RIKEN Centre for Integrative Medical Sciences, Laboratory for Endocrinology, Metabolism and Kidney Diseases, Yokohama, Japan.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Day FR; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Helgeland Ø; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.; Department of Genetics and Bioinformatics, Domain of Health Data and Digitalisation, Norwegian Institute of Public Health, Oslo, Norway., Laurin C; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Bacelis J; Department of Obstetrics and Gynecology, Sahlgrenska University Hospital Östra, Gothenburg, Sweden., Peng S; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hao K; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Feenstra B; Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark., Wood AR; Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Tyrrell J; Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK.; European Centre for Environment and Human Health, University of Exeter, Truro, UK., Robertson NR; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Rayner NW; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Wellcome Sanger Institute, Hinxton, UK., Qiao Z; University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia., Moen GH; Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Vaudel M; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway., Marsit CJ; Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Chen J; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Nodzenski M; Department of Preventive Medicine, Division of Biostatistics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Schnurr TM; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Zafarmand MH; Department of Public Health, Amsterdam Public Health Research Institute, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam Public Health Research Institute, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Bradfield JP; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Quantinuum Research, San Diego, CA, USA., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kooijman MN; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Geller F; Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark., Ahluwalia TS; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Gentofte, Denmark., Paternoster L; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Rueedi R; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Huikari V; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland., Hottenga JJ; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health, Amsterdam, the Netherlands., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Cavadino A; Section of Epidemiology and Biostatistics, School of Population Health, University of Auckland, Auckland, New Zealand.; Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, University College London, London, UK., Metrustry S; Department of Twin Research, King's College London, St. Thomas' Hospital, London, UK., Cousminer DL; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wu Y; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Thiering E; Institute of Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg, Germany.; Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany., Wang CA; School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Newcastle, New South Wales, Australia., Have CT; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Vilor-Tejedor N; Center for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain.; Barcelonabeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain., Joshi PK; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Painter JN; QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Brisbane, Queensland, Australia., Ntalla I; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Myhre R; Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway., Pitkänen N; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., van Leeuwen EM; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Joro R; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland., Lagou V; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Neuroscience, Katholieke Universiteit Leuven, Leuven, Belgium.; VIB Center for Brain and Disease Research, Leuven, Belgium., Richmond RC; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Espinosa A; ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; CIBER de Epidemiología y Salud Pública, Madrid, Spain.; Hospital del Mar Medical Research Institute, Barcelona, Spain., Barton SJ; Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK., Inskip HM; Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK., Holloway JW; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK., Santa-Marina L; CIBER de Epidemiología y Salud Pública, Madrid, Spain.; Subdirección de Salud Pública y Adicciones de Gipuzkoa, San Sebastián, Spain.; Instituto de Investigación Sanitaria Biodonostia, San Sebastián, Spain., Estivill X; Sidra Medicine Research Department, Sidra Medicine, Doha, Qatar.; Genomics Unit, Dexeus Woman's Health, Barcelona, Spain., Ang W; Division of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia., Marsh JA; Division of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia., Reichetzeder C; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany., Marullo L; Department of Life Sciences and Biotechnology, Genetic Section, University of Ferrara, Ferrara, Italy., Hocher B; Fifth Department of Medicine, University Medical Centre Mannheim, University of Heidelberg, Heidelberg, Germany.; Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China., Lunetta KL; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA., Murabito JM; Framingham Heart Study, Framingham, MA, USA.; Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Relton CL; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Kogevinas M; ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; CIBER de Epidemiología y Salud Pública, Madrid, Spain.; Hospital del Mar Medical Research Institute, Barcelona, Spain., Chatzi L; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA., Allard C; Centre de recherche, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada., Bouchard L; Centre de recherche, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.; ECOGENE-21 and Lipid Clinic, Chicoutimi Hospital, Saguenay, Quebec, Canada.; Department of Biochemistry, Université de Sherbrooke, Sherbrooke, Quebec, Canada., Hivert MF; Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, MA, USA.; Diabetes Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Universite de Sherbrooke, Sherbooke, Quebec, Canada., Zhang G; Human Genetics Division, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, OH, USA., Muglia LJ; Human Genetics Division, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, OH, USA., Heikkinen J; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Morgen CS; Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., van Kampen AHC; Bioinformatics Laboratory, Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam Public Health Research Institute, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.; Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands., van Schaik BDC; Bioinformatics Laboratory, Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam Public Health Research Institute, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Mentch FD; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Zhao JH; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Hemani G; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Ring SM; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Bennett AJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Gaulton KJ; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Fernandez-Tajes J; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., van Zuydam NR; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Medina-Gomez C; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., de Haan HG; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Kutalik Z; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland., Marques-Vidal P; Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland., Das S; Medical Research Council Unit for Lifelong Health and Ageing at UCL, Institute of Cardiovascular Sciences, University College London, London, UK., Willemsen G; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health, Amsterdam, the Netherlands., Mbarek H; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health, Amsterdam, the Netherlands.; Amsterdam Reproduction and Development, Amsterdam, the Netherlands., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg, Germany.; Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.; Division of Genetic Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology, Faculty of Medicine, Ludwig-Maximilians-University Munich, Munich, Germany., Standl M; Institute of Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg, Germany., Appel EVR; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Fonvig CE; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark.; Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark., Trier C; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark., van Beijsterveldt CEM; Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Murcia M; CIBER de Epidemiología y Salud Pública, Madrid, Spain.; FISABIO-Universitat Jaume I-Universitat de València, Joint Research Unit of Epidemiology and Environmental Health, Valencia, Spain., Bustamante M; ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; CIBER de Epidemiología y Salud Pública, Madrid, Spain., Bonas-Guarch S; Joint BSC-CGR-IRB Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain., Hougaard DM; Danish Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark., Mercader JM; Joint BSC-CGR-IRB Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain.; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Linneberg A; Department of Clinical Medicine, Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark.; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark., Schraut KE; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Lind PA; QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Brisbane, Queensland, Australia., Medland SE; QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Brisbane, Queensland, Australia., Shields BM; NIHR Exeter Clinical Research Facility, University of Exeter College of Medicine and Health and Royal Devon and Exeter NHS Foundation Trust, Exeter, UK., Knight BA; NIHR Exeter Clinical Research Facility, University of Exeter College of Medicine and Health and Royal Devon and Exeter NHS Foundation Trust, Exeter, UK., Chai JF; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore., Panoutsopoulou K; Wellcome Sanger Institute, Hinxton, UK., Bartels M; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health, Amsterdam, the Netherlands., Sánchez F; Joint BSC-CGR-IRB Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain.; Computer Sciences Department, Barcelona Supercomputing Center, Barcelona, Spain., Stokholm J; Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Torrents D; Joint BSC-CGR-IRB Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain., Vinding RK; Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Willems SM; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Atalay M; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland., Chawes BL; Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Kovacs P; IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany., Prokopenko I; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Section of Genomics of Common Disease, Department of Medicine, Imperial College London, London, UK., Tuke MA; Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK., Yaghootkar H; Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK., Ruth KS; Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK., Jones SE; Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK., Loh PR; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Murray A; Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK., Weedon MN; Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK., Tönjes A; Medical Department, University of Leipzig, Leipzig, Germany., Stumvoll M; IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.; Medical Department, University of Leipzig, Leipzig, Germany., Michaelsen KF; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark., Eloranta AM; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland., Lakka TA; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., van Duijn CM; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Kiess W; Pediatric Research Center, Department of Women's andChild Health, University of Leipzig, Leipzig, Germany., Körner A; IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.; Pediatric Research Center, Department of Women's andChild Health, University of Leipzig, Leipzig, Germany., Niinikoski H; Department of Pediatrics, Turku University Hospital, Turku, Finland.; Department of Physiology, University of Turku, Turku, Finland., Pahkala K; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland., Raitakari OT; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland., Jacobsson B; Department of Genetics and Bioinformatics, Domain of Health Data and Digitalisation, Norwegian Institute of Public Health, Oslo, Norway.; Department of Obstetrics and Gynecology, Sahlgrenska University Hospital Östra, Gothenburg, Sweden., Zeggini E; Wellcome Sanger Institute, Hinxton, UK.; Institute of Translational Genomics, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg, Germany., Dedoussis GV; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece., Teo YY; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.; Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore.; Life Sciences Institute, National University of Singapore, Singapore, Singapore., Saw SM; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.; Singapore Eye Research Institute, Singapore, Singapore., Montgomery GW; QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Brisbane, Queensland, Australia., Campbell H; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Wilson JF; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Vrijkotte TGM; Department of Public Health, Amsterdam Public Health Research Institute, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Vrijheid M; ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; CIBER de Epidemiología y Salud Pública, Madrid, Spain., de Geus EJCN; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health, Amsterdam, the Netherlands., Hayes MG; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Kadarmideen HN; Quantitative and Systems Genomics Group, Department of Bio and Health Informatics, Technical University of Denmark, Lyngby, Denmark., Holm JC; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark., Beilin LJ; School of Medicine, Royal Perth Hospital, University of Western Australia, Perth, Western Australia, Australia., Pennell CE; School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Newcastle, New South Wales, Australia., Heinrich J; Institute of Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg, Germany.; Institute and Outpatient Clinic for Occupational Social and Environmental Medicine, Inner City Clinic, University Hospital Munich, Ludwig-Maximilians-University Munich, Munich, Germany., Adair LS; Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA., Borja JB; USC-Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines.; Department of Nutrition and Dietetics, University of San Carlos, Cebu City, Philippines., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Eriksson JG; National Institute for Health and Welfare, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Folkhälsan Research Center, Helsinki, Finland., Widén EE; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Hattersley AT; Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK.; NIHR Exeter Clinical Research Facility, University of Exeter College of Medicine and Health and Royal Devon and Exeter NHS Foundation Trust, Exeter, UK., Spector TD; Department of Twin Research, King's College London, St. Thomas' Hospital, London, UK., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.; Department of Clinical Physiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Viikari JS; Division of Medicine, Turku University Hospital, Turku, Finland.; Department of Medicine, University of Turku, Turku, Finland., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Boomsma DI; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health, Amsterdam, the Netherlands.; Amsterdam Reproduction and Development, Amsterdam, the Netherlands., Sebert S; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Biocenter Oulu, University of Oulu, Oulu, Finland.; Department of Genomics of Complex Diseases, Imperial College London, London, UK., Vollenweider P; Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland., Sørensen TIA; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bisgaard H; Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Bønnelykke K; Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Murray JC; Department of Pediatrics, University of Iowa, Iowa City, IA, USA., Melbye M; Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark.; Department of Medicine, Stanford School of Medicine, Stanford, CA, USA., Nohr EA; Research Unit for Gynaecology and Obstetrics, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands., Rivadeneira F; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Hofman A; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Felix JF; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Jaddoe VWV; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pisinger C; Research Center for Prevention and Health, Center for Sundhed, Rigshospitalet Glostrup, Copenhagen University, Glostrup, Denmark., Vaag AA; Department of Clinical Medicine, Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark.; Cardiovascular, Renal and Metabolism, Translational Medicine Unit, Early Clinical Development, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Uitterlinden AG; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Järvelin MR; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Biocenter Oulu, University of Oulu, Oulu, Finland.; Unit of Primary Health Care, Oulu University Hospital, Oulu, Finland.; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK., Power C; Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, University College London, London, UK., Hyppönen E; Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.; Australian Centre for Precision Health, University of South Australia Cancer Research Institute, Adelaide, South Australia, Australia.; South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia., Scholtens DM; Department of Preventive Medicine, Division of Biostatistics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Lowe WL Jr; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Davey Smith G; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; NIHR Bristol Biomedical Research Centre, Bristol, UK., Timpson NJ; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; 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Publikováno v: Nature genetics [Nat Genet] 2019 May; Vol. 51 (5), pp. 804-814. Date of Electronic Publication: 2019 May 01.