Zobrazeno 1 - 10
of 754
pro vyhledávání: '"Wickliffe C"'
Autor:
Amanda L. Wright, Lyndsey M. Konen, Bruce G. Mockett, Gary P. Morris, Anurag Singh, Lisseth Estefania Burbano, Luke Milham, Monica Hoang, Raphael Zinn, Rose Chesworth, Richard P. Tan, Gordon A. Royle, Ian Clark, Steven Petrou, Wickliffe C. Abraham, Bryce Vissel
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-25 (2023)
Abstract Background RNA editing at the Q/R site of GluA2 occurs with ~99% efficiency in the healthy brain, so that the majority of AMPARs contain GluA2(R) instead of the exonically encoded GluA2(Q). Reduced Q/R site editing increases AMPA receptor ca
Externí odkaz:
https://doaj.org/article/b9e4dab9637d4341b888d7fc34854075
Autor:
Kevin Lee, Yewon Jung, Yukti Vyas, Imogen Skelton, Wickliffe C. Abraham, Yi-Ping Hsueh, Johanna M. Montgomery
Publikováno v:
Molecular Autism, Vol 13, Iss 1, Pp 1-20 (2022)
Abstract Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by a dyad of behavioural symptoms—social and communication deficits and repetitive behaviours. Multiple aetiological genetic and environmental factors
Externí odkaz:
https://doaj.org/article/9f35f124a8be491d8d53da81e5d14ca3
Autor:
Leon C. D. Smyth, Helen C. Murray, Madison Hill, Eve van Leeuwen, Blake Highet, Nicholas J. Magon, Mahyar Osanlouy, Sophie N. Mathiesen, Bruce Mockett, Malvindar K. Singh-Bains, Vanessa K. Morris, Andrew N. Clarkson, Maurice A. Curtis, Wickliffe C. Abraham, Stephanie M. Hughes, Richard L. M. Faull, Anthony J. Kettle, Mike Dragunow, Mark B. Hampton
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Introduction Neutrophil accumulation is a well-established feature of Alzheimer’s disease (AD) and has been linked to cognitive impairment by modulating disease-relevant neuroinflammatory and vascular pathways. Neutrophils express high lev
Externí odkaz:
https://doaj.org/article/4881c6c2cd424db9be6a4d32261c425f
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Long-term potentiation (LTP) is regulated in part by metaplasticity, the activity-dependent alterations in neural state that coordinate the direction, amplitude, and persistence of future synaptic plasticity. Previously, we documented a hete
Externí odkaz:
https://doaj.org/article/ef8274d299fc4027ab571db3a8555dad
Autor:
Shane M. Ohline, Connie Chan, Lucia Schoderboeck, Hollie E. Wicky, Warren P. Tate, Stephanie M. Hughes, Wickliffe C. Abraham
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-18 (2022)
Abstract Soluble amyloid precursor protein-alpha (sAPPα) is a regulator of neuronal and memory mechanisms, while also having neurogenic and neuroprotective effects in the brain. As adult hippocampal neurogenesis is impaired in Alzheimer’s disease,
Externí odkaz:
https://doaj.org/article/34bce049805343a4889650cc7524a1b1
Autor:
Shane M. Ohline, Xinhuai Liu, Mohamed F. Ibrahim, Bruce M. Mockett, Ruth M. Empson, Wickliffe C. Abraham, Karl J. Iremonger, Peter P. Jones
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Neuronal hyperexcitability in Alzheimer’s disease (AD) models is thought to either contribute to the formation of amyloid beta plaques or result from their formation. Neuronal hyperexcitability has been shown in the cerebral cortex of the widely us
Externí odkaz:
https://doaj.org/article/474e1a9c63974561aee358cc88482080
Autor:
Sophie N. Mathiesen, Jasmine L. Lock, Lucia Schoderboeck, Wickliffe C. Abraham, Stephanie M. Hughes
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 447-458 (2020)
Adeno-associated viral (AAV) vectors are attractive tools for central nervous system (CNS) gene therapy because some vectors can cross the blood-brain barrier (BBB), allowing them to be used as minimally invasive treatments. A novel AAV vector recent
Externí odkaz:
https://doaj.org/article/8ef64cc3e9cc4b138ce8773bc9af7587
Autor:
Rhys W. Livingstone, Megan K. Elder, Anurag Singh, Courteney M. Westlake, Warren P. Tate, Wickliffe C. Abraham, Joanna M. Williams
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Regulation of AMPA receptor expression by neuronal activity and neuromodulators is critical to the expression of both long-term potentiation (LTP) and memory. In particular, Ca2+-permeable AMPARs (CP-AMPAR) play a unique role in these processes due t
Externí odkaz:
https://doaj.org/article/9290877e3a9240328cd488775be4af9a
Autor:
Valerie T. Y. Tan, Bruce G. Mockett, Shane M. Ohline, Karen D. Parfitt, Hollie E. Wicky, Katie Peppercorn, Lucia Schoderboeck, Mohamad Fairuz bin Yahaya, Warren P. Tate, Stephanie M. Hughes, Wickliffe C. Abraham
Publikováno v:
Molecular Brain, Vol 11, Iss 1, Pp 1-16 (2018)
Abstract Alzheimer’s disease (AD) is a neurodegenerative disease driven in large part by accumulated deposits in the brain of the amyloid precursor protein (APP) cleavage product amyloid-β peptide (Aβ). However, AD is also characterised by reduct
Externí odkaz:
https://doaj.org/article/829842a4c1ec4ba690c8af863cc84017
Autor:
Simon D. Fisher, Paul B. Robertson, Melony J. Black, Peter Redgrave, Mark A. Sagar, Wickliffe C. Abraham, John N.J. Reynolds
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Spike timing dependent plasticity (STDP) has been studied extensively in slices but whether such pairings can induce plasticity in vivo is not known. Here the authors report an experimental paradigm that achieves bidirectional corticostriatal STDP in
Externí odkaz:
https://doaj.org/article/94ba55734bfc4318a5c02d00eab6d896