Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway.

Autor: Zhang J; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA. Electronic address: jzhang75@mgh.harvard.edu., Simpson CM; Cell Signaling Technology, Inc., Danvers, MA, USA., Berner J; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Chong HB; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Fang J; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Ordulu Z; Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA., Weiss-Sadan T; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Possemato AP; Cell Signaling Technology, Inc., Danvers, MA, USA., Harry S; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Takahashi M; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Yang TY; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Richter M; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Patel H; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Smith AE; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Carlin AD; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Hubertus de Groot AF; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Wolf K; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Shi L; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Wei TY; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Dürr BR; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Chen NJ; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Vornbäumen T; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Wichmann NO; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Mahamdeh MS; Division of Cardiology, Harvard Medical School, Boston, MA, USA; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Pooladanda V; Department of Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA; Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA., Matoba Y; Department of Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA; Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA., Kumar S; Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA., Kim E; Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA., Bouberhan S; Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA., Oliva E; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Rueda BR; Department of Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA; Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA., Soberman RJ; Division of Nephrology, Harvard Medical School, Boston, MA, USA; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Bardeesy N; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA., Liau BB; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Lawrence M; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA., Stokes MP; Cell Signaling Technology, Inc., Danvers, MA, USA., Beausoleil SA; Cell Signaling Technology, Inc., Danvers, MA, USA., Bar-Peled L; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA. Electronic address: lbar-peled@mgh.harvard.edu.

Publikováno v: Cell [Cell] 2023 May 25; Vol. 186 (11), pp. 2361-2379.e25. Date of Electronic Publication: 2023 May 15.