Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Wichard Tilstra"'
Autor:
Thomas J. M. Michiels, Wichard Tilstra, Martin R. J. Hamzink, Justin W. de Ridder, Maarten Danial, Hugo D. Meiring, Gideon F. A. Kersten, Wim Jiskoot, Bernard Metz
Publikováno v:
Vaccines, Vol 8, Iss 4, p 712 (2020)
Currently, batch release of toxoid vaccines, such as diphtheria and tetanus toxoid, requires animal tests to confirm safety and immunogenicity. Efforts are being made to replace these tests with in vitro assays in a consistency approach. Limitations
Externí odkaz:
https://doaj.org/article/6f84b0f9ce2b4132853060a14e99cd7c
Autor:
René H M Raeven, Jolanda Brummelman, Larissa van der Maas, Wichard Tilstra, Jeroen L A Pennings, Wanda G H Han, Cécile A C M van Els, Elly van Riet, Gideon F A Kersten, Bernard Metz
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164027 (2016)
Effective immunity against Bordetella pertussis is currently under discussion following the stacking evidence of pertussis resurgence in the vaccinated population. Natural immunity is more effective than vaccine-induced immunity indicating that knowl
Externí odkaz:
https://doaj.org/article/78bc31373c134ef5acebab6205dd1bd5
Autor:
Nanda Spruit, Wichard Tilstra, Janny Westdijk, Bernard Metz, Coenraad F.M. Hendriksen, Gideon F.A. Kersten, Johan van der Gun
Publikováno v:
Biologicals, 47, 69-75
The antigenicity of alum-adsorbed diphtheria toxoid (DTd) was determined in combination vaccines, containing DTd, tetanus toxoid and inactivated poliovirus. A panel of monoclonal antibodies was used, covering five epitopes, distributed over the antig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7db31eea7d472edbbb4775f325ee91
https://doi.org/10.1016/j.biologicals.2016.10.005
https://doi.org/10.1016/j.biologicals.2016.10.005
Autor:
Geert P M Mommen, Leo A. van der Pol, Bas van de Waterbeemd, Jeroen L. A. Pennings, Michel Weyts, Marieke Hoonakker, Arno van der Ark, Hugo D. Meiring, Betsy Kuipers, Joost P. Uittenbogaard, Arjen Sloots, Jan van den IJssel, Bernard Metz, Wichard Tilstra
Publikováno v:
Journal of Proteome Research. 16:528-537
Physicochemical and immunochemical assays were applied to substantiate the relation between upstream processing and the quality of whole-cell pertussis vaccines. Bordetella pertussis bacteria were cultured on a chemically defined medium using a conti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b9fb62c1ddb241e25d94b86a225907
https://doi.org/10.1021/acs.jproteome.6b00668
https://doi.org/10.1021/acs.jproteome.6b00668
Autor:
Wim Jiskoot, Wichard Tilstra, Gideon F.A. Kersten, Maarten Danial, Hugo D. Meiring, Martin R.J. Hamzink, Bernard Metz, Thomas J M Michiels, Justin W. de Ridder
Publikováno v:
Vaccines
Volume 8
Issue 4
Vaccines, Vol 8, Iss 712, p 712 (2020)
Volume 8
Issue 4
Vaccines, Vol 8, Iss 712, p 712 (2020)
Currently, batch release of toxoid vaccines, such as diphtheria and tetanus toxoid, requires animal tests to confirm safety and immunogenicity. Efforts are being made to replace these tests with in vitro assays in a consistency approach. Limitations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f376c683e8cecd46b672200b3f35c3
https://doi.org/10.3390/vaccines8040712
https://doi.org/10.3390/vaccines8040712
Autor:
Humphrey F. Brugghe, Wichard Tilstra, Peter Hoogerhout, Harry van Steeg, Janny Westdijk, Cornelis Kees Mulder, Ulrich L. M. Eisel, Yun Dong, Elly van Riet, Hans A. M. Timmermans
Publikováno v:
Journal of Alzheimer's Disease
Journal of Alzheimer’s Disease, 52(3), 1111-1123. IOS Press
Journal of Alzheimer’s Disease, 52(3), 1111-1123. IOS Press
Background: Soluble oligomeric (misfolded) species of amyloid-beta (A beta) are the main mediators of toxicity in Alzheimer's disease (AD). These oligomers subsequently form aggregates of insoluble fibrils that precipitate as extracellular and periva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7ea0c2cae622bb6360db7a704cf15b
http://europepmc.org/articles/PMC4927839
http://europepmc.org/articles/PMC4927839
Autor:
Wichard Tilstra, A. Van Der Ark, Bernard Metz, A. Sloots, L van der Maas, Jolanda Brummelman, Jeroen L. A. Pennings, P. Van Der Ley, Wanda G. H. Han, Wim Jiskoot, Gideon F.A. Kersten, René H. M. Raeven, E. Van Riet, C A C M van Els, Kina Helm, W. van Eden
Publikováno v:
Mucosal Immunology
Mucosal immunity is often required for protection against respiratory pathogens but the underlying cellular and molecular mechanisms of induction remain poorly understood. Here, systems vaccinology was used to identify immune signatures after pulmona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f145d814c2894a1ff374754e25e25120
https://pubmed.ncbi.nlm.nih.gov/28930286
https://pubmed.ncbi.nlm.nih.gov/28930286
Autor:
Wanda G. H. Han, Wim Jiskoot, René H. M. Raeven, Wichard Tilstra, Elly van Riet, Jolanda Brummelman, Kina Helm, Jeroen L. A. Pennings, Gideon F.A. Kersten, Bernard Metz, Cécile A. C. M. van Els, Larissa van der Maas
Publikováno v:
SCIENTIFIC REPORTS
SCIENTIFIC REPORTS, 6, 38240
Scientific Reports
SCIENTIFIC REPORTS, 6, 38240
Scientific Reports
The demand for improved pertussis vaccines is urgent due to the resurgence of whooping cough. A deeper understanding of the mode of action of pertussis vaccines is required to achieve this improvement. The vaccine-induced effects of a candidate outer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a229258d821a3a353a4e2ee15f96371e
https://doi.org/10.1038/srep38240
https://doi.org/10.1038/srep38240
Autor:
Elly van Riet, Larissa van der Maas, Wichard Tilstra, René H. M. Raeven, Cécile A. C. M. van Els, Gideon F.A. Kersten, Jolanda Brummelman, Jeroen L. A. Pennings, Wanda G. H. Han, Bernard Metz
Publikováno v:
PLOS ONE, 11(10), 0164027
PLOS ONE
PLoS ONE, Vol 11, Iss 10, p e0164027 (2016)
PLoS ONE
PLOS ONE
PLoS ONE, Vol 11, Iss 10, p e0164027 (2016)
PLoS ONE
Effective immunity against Bordetella pertussis is currently under discussion following the stacking evidence of pertussis resurgence in the vaccinated population. Natural immunity is more effective than vaccine-induced immunity indicating that knowl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ed0c9d1587cb961f9a59764a5872d4
http://hdl.handle.net/1887/45953
http://hdl.handle.net/1887/45953
Autor:
Coenraad F.M. Hendriksen, Willem Norde, Gideon F.A. Kersten, Wichard Tilstra, Marie Régnier, Bernard Metz, Wim Jiskoot
Publikováno v:
Vaccine 30 (2012) 48
Vaccine, 30(48), 6783-6788
Vaccine, 30(48), 6783-6788. ELSEVIER SCI LTD
Vaccine, 30(48), 6783-6788
Vaccine, 30(48), 6783-6788. ELSEVIER SCI LTD
Aluminium-containing adjuvants are often used to enhance the potency of vaccines. In the present work we studied whether adsorption of diphtheria toxoid to colloidal aluminium hydroxide induces conformational changes of the antigen. Diphtheria toxoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b758bc84c52dc04605c642e838938c10
https://doi.org/10.1016/j.vaccine.2012.09.020
https://doi.org/10.1016/j.vaccine.2012.09.020