Zobrazeno 1 - 10
of 1 073
pro vyhledávání: '"Wicha P"'
Autor:
Mohamed Maiga, Laurent Dembele, Perrine Courlet, Akash Khandelwal, Antoine Dara, Fanta Sogore, Ousmaila Diakité, Fatoumata O. Maiga, François Dao, Sekou Sissoko, Yacouba Barre, Siaka Goita, Mahamadou Diakite, Seidina A. S. Diakite, Abdoulaye A. Djimde, Claude Oeuvray, Thomas Spangenberg, Sebastian G. Wicha, Claudia Demarta-Gatsi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The selection and combination of dose regimens for antimalarials involve complex considerations including pharmacokinetic and pharmacodynamic interactions. In this study, we use immediate ex vivo P. falciparum field isolates to evaluate the
Externí odkaz:
https://doaj.org/article/11725860ac3a4f6099cdcb6b162815eb
Autor:
Szymańczyk Sylwia, Kras Katarzyna, Osiak-Wicha Cezary, Kapica Małgorzata, Puzio Iwona, Antushevich Hanna, Kuwahara Atsukazu, Kato Ikuo, Arciszewski Marcin B.
Publikováno v:
Journal of Veterinary Research, Vol 68, Iss 3, Pp 461-468 (2024)
This study investigated the effects of intragastric administration of apelin-13 on the secretion of critical pancreatic hormones in a cohort of three-week-old Wistar rats. The research aimed to uncover apelin’s modulatory roles in endocrine interac
Externí odkaz:
https://doaj.org/article/2a0371943eec4932ac9e3effe545e993
Autor:
Cezary Osiak-Wicha, Katarzyna Kras, Ewa Tomaszewska, Siemowit Muszyński, Marcin B. Arciszewski
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 6725-6745 (2024)
This review article comprehensively explores the role of orexigenic and anorexigenic peptides in the management of obesity in companion animals, with a focus on clinical applications. Obesity in domestic animals, particularly dogs and cats, is preval
Externí odkaz:
https://doaj.org/article/c49532570c464669889cfe5d97a0a2cc
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract We conducted a study in San Antonio, Texas, in the weeks preceding the 2022 state Governor election to determine if implicit or explicit measures of political preference could predict voter behavior. We adapted an established event-related p
Externí odkaz:
https://doaj.org/article/71908f05380742b59174286e26c3a4b4
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 4, Pp 589-598 (2024)
Abstract Lefamulin is being evaluated as a treatment for bacterial exacerbations in cystic fibrosis (CF). Ivacaftor is approved for the treatment of patients with CF. Lefamulin is a moderate CYP3A inhibitor and co‐administration with ivacaftor may
Externí odkaz:
https://doaj.org/article/9918bc92e3444c5f968714a85347cfa0
Autor:
Darshini Ayton, Andrew A Udy, Sebastian Wicha, Adam Jenney, Sue J Lee, Anton Y Peleg, Rekha Pai Mangalore, Ming Gene Chai, Jeffrey Pope, Alexander Padiglione, Arne Diehl, Llyod Roberts, Kirsty Sim, Philip Rawson-Harris, Hans G Schneider, Trish N Peel
Publikováno v:
BMJ Open, Vol 14, Iss 6 (2024)
Introduction Critically ill patients are at risk of suboptimal beta-lactam antibiotic (beta-lactam) exposure due to the impact of altered physiology on pharmacokinetics. Suboptimal concentrations can lead to treatment failure or toxicity. Therapeutic
Externí odkaz:
https://doaj.org/article/c1cba439185e45febac40f585ae3add7
Autor:
Komsta Łukasz, Wicha-Komsta Katarzyna
Publikováno v:
Arhiv za farmaciju, Vol 74, Iss 2, Pp 105-117 (2024)
Many forms of drugs are designed to undergo dissolution upon oral administration. The kinetics and efficiency of this process are critical parameters to be controlled. The methods of its evaluation are described in official guidelines issued by the F
Externí odkaz:
https://doaj.org/article/fd9570b69b3544699d45597a33aacb12
Autor:
Deeksha Sharma, Cody G. Hager, Li Shang, Lam Tran, Yongyou Zhu, Aihui Ma, Brian Magnuson, Matthew W. Lesko, Max S. Wicha, Monika L. Burness
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-17 (2023)
Abstract Background Breast cancer stem cells (BCSCs) are resistant to standard therapies, facilitate tumor dissemination, and contribute to relapse and progression. Super-enhancers are regulators of stemness, and BET proteins, which are critical for
Externí odkaz:
https://doaj.org/article/6f7b31ca863f456889a102d656ed7db6
Autor:
Marta Marszalek-Grabska, Monika Turska-Kozlowska, Edyta Kaczorek-Lukowska, Katarzyna Wicha-Komsta, Waldemar A. Turski, Andrzej K. Siwicki, Kinga Gawel
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1148 (2024)
Kynurenic acid (KYNA) is a metabolite of tryptophan formed on the kynurenine pathway. Its pharmacological effects are relatively well characterized in mammals, whereas its role in fish is poorly understood. Therefore, the aim of the study was to expa
Externí odkaz:
https://doaj.org/article/44ee75576d6342c2b2d40231e907ca10
Autor:
Tjokosela Tikiso, Valentin Fuhrmann, Christina König, Dominik Jarczak, Stefanie Iwersen-Bergmann, Stefan Kluge, Sebastian G. Wicha, Jörn Grensemann
Publikováno v:
Annals of Intensive Care, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Background In acute-on-chronic liver failure (ACLF), adequate antibiotic dosing is challenging due to changes of drug distribution and elimination. We studied the pharmacokinetics of linezolid in critically ill patients with ACLF during cont
Externí odkaz:
https://doaj.org/article/9101e6a64ee147c793ab3d1e070406b1