Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Wibke E, Diederich"'
Autor:
Raphael Reher, Allegra T. Aron, Pavla Fajtová, Paolo Stincone, Berenike Wagner, Alicia I. Pérez-Lorente, Chenxi Liu, Ido Y. Ben Shalom, Wout Bittremieux, Mingxun Wang, Kyowon Jeong, Marie L. Matos-Hernandez, Kelsey L. Alexander, Eduardo J. Caro-Diaz, C. Benjamin Naman, J. H. William Scanlan, Phil M. M. Hochban, Wibke E. Diederich, Carlos Molina-Santiago, Diego Romero, Khaled A. Selim, Peter Sass, Heike Brötz-Oesterhelt, Chambers C. Hughes, Pieter C. Dorrestein, Anthony J. O’Donoghue, William H. Gerwick, Daniel Petras
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Bioactivity-guided isolation of specialized metabolites is an iterative process. Here, the authors demonstrate a native metabolomics approach that allows for fast screening of complex metabolite extracts against a protein of interest and simultaneous
Externí odkaz:
https://doaj.org/article/b4de9418b20d4c4ebe6ea5392f4b3a2b
Autor:
Anna Sandner, Khang Ngo, Christoph P. Sager, Frithjof Scheer, Michael Daude, Wibke E. Diederich, Andreas Heine, Gerhard Klebe
Publikováno v:
Biomolecules, Vol 11, Iss 12, p 1837 (2021)
The transient specificity pocket of aldose reductase only opens in response to specific ligands. This pocket may offer an advantage for the development of novel, more selective ligands for proteins with similar topology that lack such an adaptive poc
Externí odkaz:
https://doaj.org/article/d281860ce9d74c0db718c7b1b1b9ce96
Autor:
Anke Koeniger, Pierfrancesco Polo, Anna Brichkina, Florian Finkernagel, Alexander Visekruna, Andrea Nist, Thorsten Stiewe, Michael Daude, Wibke E Diederich, Thomas M Gress, Till Adhikary, Matthias Lauth
Publikováno v:
NAR Cancer. 5
Transcriptional cancer subtypes which correlate with traits such as tumor growth, drug sensitivity or the chances of relapse and metastasis, have been described for several malignancies. The core regulatory circuits (CRCs) defining these subtypes are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15b6c374e0f519b67e877abd3f4af891
https://doi.org/10.1093/narcan/zcad007
https://doi.org/10.1093/narcan/zcad007
Autor:
Lukas Heyder, Phil M.M. Hochban, Corey Taylor, Florent Chevillard, Christof Siefker, Christian Iking, Hannes Borchardt, Achim Aigner, Gerhard Klebe, Andreas Heine, Peter Kolb, Wibke E. Diederich
Publikováno v:
European Journal of Medicinal Chemistry. 245:114914
In this study, fragment-sized hits binding to Pim-1 kinase with initially modest affinity were further optimized by combining computational, synthetic and crystallographic expertise, eventually resulting in potent ligands with affinities in the nanom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7700007544be207de848e311e21412f7
https://doi.org/10.1016/j.ejmech.2022.114914
https://doi.org/10.1016/j.ejmech.2022.114914
Autor:
Andreas Heine, Sandra Blanck, Manuel Kanitz, Wibke E. Diederich, Alexander E. Gorbalenya, Anastasia A. Gulyaeva, John Ziebuhr
Publikováno v:
Virology, 533, 21-33
Virology
Virology
Cavally virus (CavV) is a mosquito-borne plus-strand RNA virus in the family Mesoniviridae (order Nidovirales). We present X-ray structures for the CavV 3C-like protease (3CLpro), as a free enzyme and in complex with a peptide aldehyde inhibitor mimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58222649b23922f664660b67b00d79f1
https://doi.org/10.1016/j.virol.2019.05.001
https://doi.org/10.1016/j.virol.2019.05.001
Autor:
Isabell Schencking, Roland K. Hartmann, Rolf Erik Emmerich, Wibke E. Diederich, Torsten Steinmetzer, Martin Schlitzer, Eva Maria Schäfer, J H William Scanlan, Benjamin M Wenzel
Publikováno v:
Antimicrob Agents Chemother
RNase P is an essential enzyme responsible for tRNA 5′-end maturation. In most bacteria, the enzyme is a ribonucleoprotein consisting of a catalytic RNA subunit and a small protein cofactor termed RnpA. Several studies have reported small-molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62157dcf268c1025f587fc467010624
https://pubmed.ncbi.nlm.nih.gov/33972249
https://pubmed.ncbi.nlm.nih.gov/33972249
Activation of Cilia-Independent Hedgehog/GLI1 Signaling as a Novel Concept for Neuroblastoma Therapy
Autor:
Iris Nee, Ilya Galperin, Thorsten Stiewe, Matthias Lauth, Anke Koeniger, Lukas Dempwolff, Till Adhikary, Anna Brichkina, Wibke E. Diederich, Anna Hupfer, Andrea Nist, Florian Finkernagel
Publikováno v:
Cancers
Volume 13
Issue 8
Cancers, Vol 13, Iss 1908, p 1908 (2021)
Volume 13
Issue 8
Cancers, Vol 13, Iss 1908, p 1908 (2021)
Simple Summary Elevated GLI1 expression levels are associated with improved survival in NB patients and GLI1 overexpression exerts tumor-suppressive traits in cultured NB cells. However, NB cells are protected from increased GLI1 levels as they have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54386398a04600064f01f40cccc0df47
Autor:
Sylvia Krippner, Carsten Culmsee, Wibke E. Diederich, Anja Jelinek, Matthias Plessner, Lukas Heyder, Michael Daude, Robert Grosse
Publikováno v:
Free Radical Biology and Medicine. 117:45-57
Research into oxidative cell death is producing exciting new mechanisms, such as ferroptosis, in the neuropathologies of cerebral ischemia and hemorrhagic brain insults. Ferroptosis is an oxidative form of regulated necrotic cell death featuring glut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42701092379da398e441b6f7df14400b
https://doi.org/10.1016/j.freeradbiomed.2018.01.019
https://doi.org/10.1016/j.freeradbiomed.2018.01.019
Autor:
Els Pardon, Florent Chevillard, Cecilia Betti, Steven Ballet, Niek van Hilten, Peter Kolb, Wibke E. Diederich, Helena Rimmer, Jan Steyaert
Publikováno v:
Journal of Medicinal Chemistry. 61:1118-1129
Fragment-based drug discovery is intimately linked to fragment extension approaches that can be accelerated using software for de novo design. Although computers allow for the facile generation of millions of suggestions, synthetic feasibility is how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7ae09f2da84aad32cab1b59cc246dd9
https://doi.org/10.1021/acs.jmedchem.7b01558
https://doi.org/10.1021/acs.jmedchem.7b01558
Autor:
Andreas Kaufmann, Gabriele Köllisch, Alfonso J. García-Piñeres, Wibke E. Diederich, Stefan Bauer, Juan J. Araya, Kerstin Mark, Francisco A. Venegas, Max Chavarría
Publikováno v:
Scientific Reports, vol.9(13661), pp.1-17
Kérwá
Universidad de Costa Rica
instacron:UCR
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Kérwá
Universidad de Costa Rica
instacron:UCR
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Violacein, an indole-derived, purple-colored natural pigment isolated from Chromobacterium violaceum has shown multiple biological activities. In this work, we studied the effect of violacein in different immune cell lines, namely THP-1, MonoMac 6, A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c8b8424799dcfa1237231a5b8bb2a2
https://doi.org/10.1038/s41598-019-50038-x
https://doi.org/10.1038/s41598-019-50038-x