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The identification of Staphylococcus aureus factors required for pathogenicity and growth in human blood

Autor: Connolly, J., Boldock, E., Prince, L.R., Renshaw, S.A., Whyte, M.K., Foster, S.J.

Staphylococcus aureus is a human commensal but also has devastating potential as an opportunist pathogen. S. aureus bacteraemia is often associated with an adverse outcome. To identify potential targets for novel control approaches we have identified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::f0ac01441b4bc43df6aa637e0b1dfb6e

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Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD

Autor: Bewley, M.A., Belchamber, K.B., Chana, K.K., Budd, R.C., Donaldson, G., Wedzicha, J.A., Brightling, C.E., Kilty, I., Donnelly, L.E., Barnes, P.J., Singh, D., Whyte, M.K., Dockrell, D.H.

Publikováno v: Bewley, M A, Belchamber, K B R, Chana, K K, Budd, R C, Donaldson, G, Wedzicha, J A, Brightling, C E, Kilty, I, Donnelly, L E, Barnes, P J, Singh, D & Whyte, M K B & Dockrell, D 2016, ' Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD ', PLoS ONE, vol. 11, no. 9, pp. e0163139 . https://doi.org/10.1371/journal.pone.0163139
PLoS ONE
Bewley, M A, Belchamber, K B R, Chana, K K, Budd, R C, Donaldson, G, Wedzicha, J A, Brightling, C E, Kilty, I, Donnelly, L E, Barnes, P J, Singh, D, Whyte, M K B, Dockrell, D H & COPDMAP 2016, ' Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD ', PLoS ONE, vol. 11, no. 9, pp. e0163139 . https://doi.org/10.1371/journal.pone.0163139

Pulmonary inflammation and bacterial colonization are central to the pathogenesis of chronic obstructive pulmonary disease (COPD). Defects in macrophage phagocytosis of both bacteria and apoptotic cells contribute to the COPD phenotype. Small molecul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0f5e1cdf1f91ed01a502d9fb84d3a19f
https://www.pure.ed.ac.uk/ws/files/28576749/Whyte_M_Differential_effects....pdf

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Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression

Autor: Jones, R., McDonald, K.E., Willson, J.A., Ghesquière, B., Sammut, D., Daniel, E., Harris, A.J., Lewis, A., Thompson, A.A., Dickinson, R.S., Plant, T., Murphy, F., Sadiku, P., Keevil, B.G., Carmeliet, P., Whyte, M.K., Newell-Price, J., Walmsley, S.R.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::b69c0276d3689b7133ff72a7bd016f05
https://eprints.whiterose.ac.uk/99286/1/BLOOD-2016-696922v3-Walmsley.pdf

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Experimental validation of the hyperpolarized Xe-129 chemical shift saturation recovery technique in healthy volunteers and subjects with interstitial lung disease

Autor: Stewart, N.J., Leung, G., Norquay, G., Marshall, H., Parra-Robles, J., Murphy, P.S., Schulte, R.F., Elliot, C., Condliffe, R., Griffiths, P.D., Kiely, D.G., Whyte, M.K., Wolber, J., Wild, J.M.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::2d1096fd7e81e178ee44b72f7d9e75d2

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Macrophage phenotype is associated with disease severity in preterm infants with chronic lung disease

Autor: Prince, L.R., Maxwell, N.C., Gill, S.K., Dockrell, D.H., Sabroe, I., McGreal, E.P., Kotecha, S., Whyte, M.K.

Publikováno v: PLoS One

The etiology of persistent lung inflammation in preterm infants with chronic lung disease of prematurity (CLD) is poorly characterized, hampering efforts to stratify prognosis and treatment. Airway macrophages are important innate immune cells with r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::fa237af856277a4f00ae894f6d210c88
https://eprints.whiterose.ac.uk/80562/1/WRRO_80562.pdf

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HIF-mediated innate immune responses: cell signaling and therapeutic implications

Autor: Harris, A.J., Thompson, A.R., Whyte, M.K., Walmsley, S.R.

Leukocytes recruited to infected, damaged, or inflamed tissues during an immune response must adapt to oxygen levels much lower than those in the circulation. Hypoxia inducible factors (HIFs) are key mediators of cellular responses to hypoxia and, as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::7b88c081988d5c7da4eb8ca9a454db48

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