An Integrated Signaling Threshold Initiates IgG Response toward Virus-like Immunogens.

Autor: Wholey WY; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI., Meyer AR; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI., Yoda ST; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI., Mueller JL; Division of Rheumatology, Department of Medicine, University of California, San Francisco, CA., Mathenge R; Division of Rheumatology, Department of Medicine, University of California, San Francisco, CA., Chackerian B; Department of Molecular Genetics and Microbiology, School of Medicine, University of New Mexico, Albuquerque, NM., Zikherman J; Division of Rheumatology, Department of Medicine, University of California, San Francisco, CA., Cheng W; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI.; Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2024 Oct 15; Vol. 213 (8), pp. 1061-1075.

Minimal determinants for lifelong antiviral antibody responses in BALB/c mice from a single exposure to virus-like immunogens at low doses.

Autor: Wholey WY, Meyer AR, Yoda ST, Chackerian B, Zikherman J, Cheng W

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Feb 18. Date of Electronic Publication: 2024 Feb 18.

Molecular basis for potent B cell responses to antigen displayed on particles of viral size.

Autor: Brooks JF; Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Department of Medicine, University of California, San Francisco, CA, USA., Riggs J; Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Department of Medicine, University of California, San Francisco, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, CA, USA., Mueller JL; Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Department of Medicine, University of California, San Francisco, CA, USA., Mathenge R; Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Department of Medicine, University of California, San Francisco, CA, USA., Wholey WY; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA., Meyer AR; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA., Yoda ST; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA., Vykunta VS; Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Department of Medicine, University of California, San Francisco, CA, USA., Nielsen HV; Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Department of Medicine, University of California, San Francisco, CA, USA., Cheng W; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA. chengwe@umich.edu.; Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, USA. chengwe@umich.edu., Zikherman J; Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Department of Medicine, University of California, San Francisco, CA, USA. julie.zikherman@ucsf.edu.

Publikováno v: Nature immunology [Nat Immunol] 2023 Oct; Vol. 24 (10), pp. 1762-1777. Date of Electronic Publication: 2023 Aug 31.

Site-Specific and Stable Conjugation of the SARS-CoV-2 Receptor-Binding Domain to Liposomes in the Absence of Any Other Adjuvants Elicits Potent Neutralizing Antibodies in BALB/c Mice.

Autor: Wholey WY; Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109, United States., Yoda ST; Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109, United States., Cheng W; Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109, United States.; Department of Biological Chemistry, University of Michigan Medical School, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109, United States.

Publikováno v: Bioconjugate chemistry [Bioconjug Chem] 2021 Dec 15; Vol. 32 (12), pp. 2497-2506. Date of Electronic Publication: 2021 Nov 14.

Synthetic Liposomal Mimics of Biological Viruses for the Study of Immune Responses to Infection and Vaccination.

Autor: Wholey WY; Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109, United States., Mueller JL; Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Department of Medicine, University of California, San Francisco, California 94143, United States., Tan C; Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Department of Medicine, University of California, San Francisco, California 94143, United States., Brooks JF; Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Department of Medicine, University of California, San Francisco, California 94143, United States., Zikherman J; Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Department of Medicine, University of California, San Francisco, California 94143, United States., Cheng W; Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109, United States.; Department of Biological Chemistry, University of Michigan Medical School, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109, United States.

Publikováno v: Bioconjugate chemistry [Bioconjug Chem] 2020 Mar 18; Vol. 31 (3), pp. 685-697. Date of Electronic Publication: 2020 Jan 23.