Microdosing of a Carbon-14 Labeled Protein in Healthy Volunteers Accurately Predicts Its Pharmacokinetics at Therapeutic Dosages

Autor: E van Duijn, Willem Seinen, T Alves, Mlh Vlaming, Manuel J.T. Carrondo, Dillingh, A Fidder, Cristina Peixoto, Raf de Ligt, Whj Vaes, Ruud Brands, Albert D. Windhorst, MC de Koning, WJ Pasman, Hugo Sandman, N. H. Hendrikse, B.O. Fabriek, J. Burggraaf, Sieto Bosgra, Pam Peeters, Jaj Mocking

Publikováno v: Clinical Pharmacology & Therapeutics, 98(2), 196-204. Wiley-Blackwell
Clinical pharmacology and therapeutics, 2, 98, 196-204
Vlaming, M L H, van Duijn, E, Dillingh, M R, Brands, R, Windhorst, A D, Hendrikse, N H, Bosgra, S, Burggraaf, J, Koning, M C, Fidder, A, Mocking, J A J, Sandman, H, de Ligt, R A F, Fabriek, B O, Pasman, W J, Seinen, W, Alves, T, Carrondo, M, Peixoto, C, Peeters, P A M & Vaes, W H J 2015, ' Microdosing of a Carbon-14 Labeled Protein in Healthy Volunteers Accurately Predicts Its Pharmacokinetics at Therapeutic Dosages ', Clinical Pharmacology & Therapeutics, vol. 98, no. 2, pp. 196-204 . https://doi.org/10.1002/cpt.131

Preclinical development of new biological entities (NBEs), such as human protein therapeutics, requires considerable expenditure of time and costs. Poor prediction of pharmacokinetics in humans further reduces net efficiency. In this study, we show f

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Handbook of Solid Phase Microextraction

Autor: Janusz Pawliszyn

The relatively new technique of solid phase microextraction (SPME) is an important tool to prepare samples both in the lab and on-site. SPME is a'green'technology because it eliminates organic solvents from analytical laboratory and can be used in en