Molecular basis for cA6 synthesis by a type III-A CRISPR-Cas enzyme and its conversion to cA4 production.

Autor: Goswami HN; Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA., Ahmadizadeh F; Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA., Wang B; Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA., Addo-Yobo D; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA., Zhao Y; Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA., Whittington AC; Department of Biological Sciences, Florida State University, Tallahassee, FL 32306, USA., He H; Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA., Terns MP; Biochemistry and Molecular Biology, Genetics and Microbiology, University of Georgia, Athens, GA 30602, USA., Li H; Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA.; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2024 Sep 23; Vol. 52 (17), pp. 10619-10629.

Biochemical methods to map and quantify allosteric motions in human glucokinase.

Autor: Gordon BH; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL, United States; Institute of Molecular Biophysics, Florida State University, Tallahassee, FL, United States., Liu P; Protein Analytical Chemistry, Genentech Inc., South San Francisco, CA, United States., Whittington AC; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL, United States; Department of Biological Science, Florida State University, Tallahassee, FL, United States., Silvers R; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL, United States; Institute of Molecular Biophysics, Florida State University, Tallahassee, FL, United States., Miller BG; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL, United States. Electronic address: miller@chem.fsu.edu.

Publikováno v: Methods in enzymology [Methods Enzymol] 2023; Vol. 685, pp. 433-459. Date of Electronic Publication: 2023 Apr 19.

Nanosecond-Timescale Dynamics and Conformational Heterogeneity in Human GCK Regulation and Disease.

Autor: Sternisha SM; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida., Whittington AC; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida; Department of Biological Science, Florida State University, Tallahassee, Florida., Martinez Fiesco JA; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida., Porter C; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida., McCray MM; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida., Logan T; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida; Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida., Olivieri C; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota., Veglia G; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota; Department of Chemistry, University of Minnesota, Minneapolis, Minnesota., Steinbach PJ; Center for Molecular Modeling, Center for Information Technology, National Institutes of Health, Bethesda, Maryland. Electronic address: peter.steinbach@nih.gov., Miller BG; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida. Electronic address: bgmiller@fsu.edu.

Publikováno v: Biophysical journal [Biophys J] 2020 Mar 10; Vol. 118 (5), pp. 1109-1118. Date of Electronic Publication: 2020 Jan 14.

A Single Mutation Unlocks Cascading Exaptations in the Origin of a Potent Pitviper Neurotoxin.

Autor: Whittington AC; Department of Biological Science, Florida State University, Tallahassee, FL., Mason AJ; Department of Biology, University of Central Florida, Orlando, FL.; Department of Biological Sciences, Clemson University, Clemson, SC., Rokyta DR; Department of Biological Science, Florida State University, Tallahassee, FL.

Publikováno v: Molecular biology and evolution [Mol Biol Evol] 2018 Apr 01; Vol. 35 (4), pp. 887-898.

Resurrecting prehistoric parvalbumins to explore the evolution of thermal compensation in extant Antarctic fish parvalbumins.

Autor: Whittington AC; Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA. awhittington@chem.fsu.edu, Moerland TS

Publikováno v: The Journal of experimental biology [J Exp Biol] 2012 Sep 15; Vol. 215 (Pt 18), pp. 3281-92. Date of Electronic Publication: 2012 Jun 12.