Výsledky vyhledávání - "Whittemore G, Tingley"

A phase 1 study to evaluate the safety and LDL cholesterol-lowering effects of RG7652, a fully human monoclonal antibody against proprotein convertase subtilisin/kexin type 9

Autor: Amos Baruch, Robert Kahn, Andrew S. Peterson, Cecilia P.C. Chiu, Whittemore G. Tingley, Nageshwar Budha, Daniel Kirchhofer, Kyra J. Cowan, Yan Wu, Diana Luca, Maya Leabman, John C. Davis

Publikováno v: Clinical Cardiology. 40:503-511

Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) downregulates low-density lipoprotein (LDL) receptors, thereby leading to a rise in circulating LDL cholesterol (LDL-C). RG7652 is a fully human monoclonal antibody against PCSK9. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a11e78e3afbbef19b146c535ac36493d
https://doi.org/10.1002/clc.22687

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Effects of RG7652, a Monoclonal Antibody Against PCSK9, on LDL-C, LDL-C Subfractions, and Inflammatory Biomarkers in Patients at High Risk of or With Established Coronary Heart Disease (from the Phase 2 EQUATOR Study)

Autor: John C. Davis, Kun Peng, Thomas Gelzleichter, Laura Pascasio Harris, Alexandr Vilimovskij, Whittemore G. Tingley, Robert Kahn, Sofia Mosesova, Kyra J. Cowan, John D. Davis, Nageshwar Budha, Amos Baruch, Josh Lehrer

Publikováno v: The American journal of cardiology. 119(10)

RG7652 (MPSK3169A), a fully human immunoglobulin G1 (IgG1) monoclonal antibody directed against proprotein convertase subtilisin/kexin type 9 (PCSK9), blocks the interaction between PCSK9 and low-density lipoprotein (LDL) receptor. EQUATOR (ClinicalT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56014790e6e7975770c47e8116c8b43
https://pubmed.ncbi.nlm.nih.gov/29448977

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Modeling and Simulation to Support Phase 2 Dose Selection for RG7652, a Fully Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9

Autor: Amos Baruch, Whittemore G. Tingley, Jin Y. Jin, Maya Leabman, D. Russell Wada, Kun Peng, Nageshwar Budha, John D. Davis

RG7652 is a fully humanized monoclonal antibody targeting human PCSK9, a regulator of serum low density lipoprotein cholesterol (LDLc) levels. RG7652 prevents degradation of the hepatic LDLc receptors by blocking PCSK9 binding and thereby resulting i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d61c73da86d9fd10cb951ea4270ded
https://europepmc.org/articles/PMC4476990/

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Characterization of Protein Kinase A and Protein Kinase C Phosphorylation of the N-Methyl-D-aspartate Receptor NR1 Subunit Using Phosphorylation Site-specific Antibodies

Autor: Kimihiko Kameyama, Michael D. Ehlers, Whittemore G. Tingley, Clark T. Riley, Richard L. Huganir, Carol A. Doherty, Janine Ptak

Publikováno v: Journal of Biological Chemistry. 272:5157-5166

Modulation of N-methyl-D-aspartate receptors in the brain by protein phosphorylation may play a central role in the regulation of synaptic plasticity. To examine the phosphorylation of the NR1 subunit of N-methyl-D-aspartate receptors in situ, we hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ad2ad3cc28f986a35d0a79849a4ddb
https://doi.org/10.1074/jbc.272.8.5157

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Regulated Subcellular Distribution of the NR1 Subunit of the NMDA Receptor

Autor: Michael D. Ehlers, Richard L. Huganir, Whittemore G. Tingley

Publikováno v: Science. 269:1734-1737

NMDA (N-methyl-D-aspartate) receptors are selectively localized at the postsynaptic membrane of excitatory synapses in the mammalian brain. The molecular mechanisms underlying this localization were investigated by expressing the NR1 subunit of the N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc2ce6da4750d23b4a3c1b7d1738c01
https://doi.org/10.1126/science.7569904

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Glutamate receptor phosphorylation and synaptic plasticity

Autor: Katherine W. Roche, Richard L. Huganir, Whittemore G. Tingley

Publikováno v: Current Opinion in Neurobiology. 4:383-388

The recent findings that glutamate receptors are phosphorylated and functionally modulated by protein kinases has provided evidence that phosphorylation of these receptors may play a critical role in mechanisms of synaptic plasticity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bafddf5796b0b0809118b4efdcd6f00b
https://doi.org/10.1016/0959-4388(94)90100-7

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Development of a blood-based gene expression algorithm for assessment of obstructive coronary artery disease in non-diabetic patients

Autor: Steven A. Rosenberg, Robert S. Schwartz, Stephen G. Ellis, Susan E. Daniels, James A. Wingrove, Whittemore G. Tingley, William E. Kraus, Eric J. Topol, Philip Beineke, Ron Waksman, Michael Elashoff, Szilard Voros, John A. McPherson, Alexandra J. Lansky, Geoffrey S. Ginsburg, Naheem Tahirkheli

Publikováno v: BMC Medical Genomics
BMC Medical Genomics, Vol 4, Iss 1, p 26 (2011)

Background Alterations in gene expression in peripheral blood cells have been shown to be sensitive to the presence and extent of coronary artery disease (CAD). A non-invasive blood test that could reliably assess obstructive CAD likelihood would hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606a1e0fb846fcbae3f70156111fd826
https://pubmed.ncbi.nlm.nih.gov/21443790

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Correlation of peripheral-blood gene expression with the extent of coronary artery stenosis

Autor: Eberhard Grube, Whittemore G. Tingley, Michael Elashoff, L. Kristin Newby, Geoffrey S. Ginsburg, William E. Kraus, Susan E. Daniels, Lutz Buellesfeld, Steven Rosenberg, James A. Wingrove, Amy J. Sehnert

Publikováno v: Circulation. Cardiovascular genetics. 1(1)

Background— The molecular pathophysiology of coronary artery disease (CAD) includes cytokine release and a localized inflammatory response within the vessel wall. The extent to which CAD and its severity is reflected by gene expression in circulati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb363f6c1afb4aa8ca97d0d9ea7430e7
https://pubmed.ncbi.nlm.nih.gov/20031539

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AKAP10 (I646V) Functional Polymorphism Predicts Heart Rate and Heart Rate Variability in Apparently Healthy, Middle-aged European-Americans

Autor: Serina A. Neumann, Matthew F. Muldoon, Robert E. Ferrell, Eloise Peet, Stephen B. Manuck, J. Richard Jennings, Whittemore G. Tingley, Bruce R. Conklin, Catherine J. Shrader

Cardiovascular disease is a leading cause of death in the U.S. with sudden cardiac death (SCD) taking an estimated 300,000 to 460,000 adult lives each year in the U.S (Zheng et al., 2001; de Vreede-Swagemakers et al., 1997; 2007). Unfortunately, SCD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b9bee5c45e89d3e2935aaffa131513b
https://europepmc.org/articles/PMC2890278/

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